“…Others reported an abnormal sterol in the white matter of the brain in one patient with sex-linked Schilder's disease (4). Forsyth et al (5) reported an absolute and relative increase in esterified cholesterol in the brains of a number of patients with Schilder's disease. Pathologic studies of the adrenal glands have also revealed distinctive changes in the adrenal cortex (nests of ballooned, nonsudanophilic cortical cells containing cytoplasmic aggregates of birefringent crystals) (16), which have been found in other disorders with other abnormalities in cholesterol metabolism, e.g., Wolman's disease (10).…”