Oestronstoffwechsel in der Mikrosomen-Fraktion der Leber von menschlichen Feten und von einem erwachsenen Mann

Estrogens in maternal plasma following intraamniotic injection of (3H)-dehydroepiandrosterone-sulfate in midpregnancy

“…Previous investigators have shown that prior to the 20th week of gestation the fetus sw.allows significant volumes of amniotic fluid. The high 16 -hydroxylaseactivity of the fetal liver [9,11] causes C 16 -hydroxylation of 75% of all recovered metabolites (Tab. I): The main 16-hydroxylated metabolite is 16a-OH-DHEA and after placentapassage 16a-OH-estrone and estriol.…”