Oestrogens for urinary incontinence in women

Moehrer, Birgit; Hextall, Andrew; Jackson, Sonia

doi:10.1002/14651858.cd001405

Cited by 141 publications

(74 citation statements)

References 39 publications

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“…Feeding studies have reported an increase in serum oestrogens with a high fat diet (Wu et al, 1999) and a strong positive association between adiposity and serum oestrogen levels has been documented in postmenopausal women (Hankinson et al, 1998;Key & Allen 2001). However, oestrogens have many essential functions in the urethra and bladder (Hextall, 2000), and a recent meta-analysis reports that oestrogen therapy improves urinary incontinence in postmenopausal women, although an improvement is more likely with urge incontinence compared with SUI (Moehrer et al, 2003). Physiological and clinical evidence therefore does not seem to support the theory of raised oestrogen as a risk factor.…”

Section: Discussionmentioning

confidence: 99%

Diet as a risk factor for the development of stress urinary incontinence: a longitudinal study in women

et al. 2004

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Objective: To assess the association between diet and the onset of stress urinary incontinence (SUI) in women aged 40 y plus. Design and setting: The Leicestershire MRC Incontinence Study -a prospective longitudinal study of the prevalence, incidence and aetiology of urinary symptoms. Subjects and methods: A total of 5816 women aged 40 y plus and living in the community. Urinary symptoms were reported in a postal questionnaire at baseline and at 1-y follow-up. Dietary intake was assessed in a food frequency questionnaire at baseline. Results: Intakes of total fat, saturated fatty acids and monounsaturated fatty acids were associated with an increased risk of SUI onset 1 y later. Of the micronutrients studied, zinc and vitamin B12 were positively associated with SUI onset. Conclusion:The results from this prospective study suggest there may be an aetiological association between certain components of the diet and the onset of SUI. The findings need confirming and possible mechanisms to explain these associations need further investigation.

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Section: Discussionmentioning

confidence: 99%

Diet as a risk factor for the development of stress urinary incontinence: a longitudinal study in women

et al. 2004

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“…It was therefore considered that therapeutic estrogen supplementation in postmenopausal women would be beneficial delivered either locally or systemically. Overall, there is a high level of evidence that oral estrogen replacement therapy appears to increase incontinence symptoms amongst postmenopausal women, [60][61][62] and its use for this indication is therefore not recommended. Recent appraisal of evidence for topical vaginal estrogen therapy suggests that it may benefit women with incontinence but not to any consistent degree, 63 and it is currently only recommended for women with overactive bladder symptoms that are associated with mucosal atrophy.…”

Section: Estrogenmentioning

confidence: 99%

“…50,56,60,64,68,71,[83][84][85]87,88,106,201,[224][225][226][227][228] What our study has added is the systematic review and overview of the treatments relevant to the NHS, where evidence on the relative effectiveness has been derived using more advanced methods of meta-analysis than have been used previously. These methods have allowed us to provide clearer evidence about which treatments work and how well they work than was hitherto available.…”

Section: Strengths Assumptions Limitations and Uncertaintiesmentioning

confidence: 99%

Systematic review and economic modelling of the effectiveness and cost-effectiveness of non-surgical treatments for women with stress urinary incontinence

Imamura

Abrams²,

Bain³

et al. 2010

Health Technol Assess

165

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address. Paying by credit cardYou can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume. How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projec...

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“…Salomon reported in 1941 the successful use of estrogen to treat UI [4]. More recently, both a Cochrane review from 2003 [5] and a study from Fantl et al [6] report improvement of urinary tract infections as well as urge and stress incontinence symptoms from HT when compared to placebo. However, other studies show no improvement [7,8], worsening of preexisting incontinence or even de novo incontinence when HT was introduced [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study

Hamer

Källén

Lidfeldt

et al. 2011

European Journal of Obstetrics & Gynecology and Reproductiv

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Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study.Andrada, Maria; Källén, Karin; Lidfeldt, Jonas; Samsioe, Göran; Teleman, Pia General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. We believe the majority of urgency symptoms in perimenopausal women to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck. If this is the case, there would be no difference in estradiol levels between the groups. Study design:Setting: university hospital. In the observational Women´s Health In the Lund Area study, a subset of 400/2221 women reporting urinary incontinence completed a detailed questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone levels measured.Statistical analyses were made by Chi-square test, nonparametrical tests, ANOVA, multi-and univariate logistic regression analysis. Results:Stress incontinence was reported by 196, mixed incontinence by 153 and urge incontinence by 43 women. Serum estradiol did not differ significantly between stress incontinent (median 49.5 pmo/l, range 2.63-875.4), urge incontinent ( median 31.6 pmol/l, range 2.63-460.7) or mixed incontinent women ( median 35.5 pmol/l, range 2.63-787.9, p = 0.62). Logistic regression analysis correcting for age, parity, hormonal status, smoking, hysterectomy and BMI also failed to show any difference in estradiol levels between the groups (p=0.41-0.58). Conclusion:No significant differences in serum estradiol levels between stress, mixed or urge incontinent perimenopausal women could be demonstrated . 4Keywords:Female urinary incontinence; mixed urinary incontinence; serum estradiol; stress urinary incontinence; urge urinary incontinence.5

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Oestrogens for urinary incontinence in women

Cited by 141 publications

References 39 publications

Diet as a risk factor for the development of stress urinary incontinence: a longitudinal study in women

Diet as a risk factor for the development of stress urinary incontinence: a longitudinal study in women

Systematic review and economic modelling of the effectiveness and cost-effectiveness of non-surgical treatments for women with stress urinary incontinence

Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study

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