Oestrogens and wound healing

Calvin, Melissa

doi:10.1016/s0378-5122(99)00079-1

Cited by 53 publications

(30 citation statements)

References 70 publications

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“…ER-b is well known to be implicated in tissue healing secondary to different types of injuries. [16][17][18][19][20] Its expression was found previously to be significantly increased after irradiation of rat mammary gland. 23 Even though ER-b is only upregulated transiently in the soft tissues in fracture healing.…”

Section: Discussionmentioning

confidence: 74%

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Differential expression of steroid receptors in prostate tissues before and after radiation therapy for prostatic adenocarcinoma

Torlakovic

Lilleby²,

Berner

et al. 2005

Intl Journal of Cancer

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The expression, distribution and the role of steroid receptors in benign and malignant untreated prostate tissues is well recognized, however, the status of steroid receptors in prostate after radiotherapy (RT) for adenocarcinoma has not yet been studied fully. Immunohistochemical evaluation of androgen receptor (AR), estrogen receptor-alpha (ER-a), estrogen receptor-beta (ER-b), and progesterone receptor (PR) was carried out in prostate needle biopsies obtained before and after radiotherapy from 60 patients with adenocarcinoma. The ER-b transcripts were also studied by RT-PCR in LNCaP prostate carcinoma cell line before and 24 hr after c-irradiation at 0.5 Gy and 8.0 Gy. Significantly higher level of ER-b expression was found in post-radiation samples of prostate adenocarcinoma and benign epithelium. After RT, all steroid receptors were upregulated in prostatic stroma. Tumor AR expression did not change significantly. Although a positive association between AR and ER-b expression was observed in pretreatment prostate adenocarcinoma, it was lost after RT suggesting that these 2 steroid receptors respond differently to RT. High levels of pretreatment tumor ER-b were associated with local recurrence after RT and decreased biochemical recurrence-free survival (p 5 0.028). LNCaP cell line that expressed no ER-b mRNA before c-irradiation, clearly expressed ER-b mRNA 24 hr after 0.5 Gy and 8.0 Gy. Upregulation of all steroid receptors in the prostate stroma and upregulation of ER-b in the tumor epithelium after RT, may represent a protective tissue response to radiation-induced tissue injury. Although stromal AR was doubled after RT, the tumor and benign epithelium expression of AR seemed resistant to change by RT. ' 2005 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 74%

“…Steroid receptors have a role in tissue repair and healing 16 ER-a was found to be increased markedly in the bone fracture callus and it also accelerates cutaneous wound healing. [17][18][19] The role of ER-a, ER-b and PR in regulating response to vascular injury was shown.…”

mentioning

confidence: 99%

Differential expression of steroid receptors in prostate tissues before and after radiation therapy for prostatic adenocarcinoma

Torlakovic

Lilleby²,

Berner

et al. 2005

Intl Journal of Cancer

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“…For this reason, we set out to test the effects of anastrozole and letrozole administered in conjunction with radiotherapy. Although estrogen deprivation could in theory exert a disadvantageous effect on postirradiation tissue remodelling (40), no change was observed in the risk of radiogenic lung sequelae. Our results accord with those of Azria and Ozsahin (25,26), who found no association between the concomitant administration of letrozole with radiotherapy and the development of subcutaneous fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Role of Systemic Therapy in the Development of Lung Sequelae After Conformal Radiotherapy in Breast Cancer Patients

Varga¹,

Cserháti²,

Kelemen³

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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Purpose: To analyze the risk of radiogenic lung damage in breast cancer patients after conformal radiotherapy and different forms of systemic treatment. Methods and Materials: In 328 patients receiving sequential taxane-based chemotherapy, concomitant hormone therapy (tamoxifen or aromatase inhibitors), or no adjuvant systemic therapy, symptomatic and asymptomatic lung sequelae were prospectively evaluated via the detection of visible CT abnormalities, 3 months or 1 year after the completion of the radiotherapy. Results: Significant positive associations were detected between the development of both pneumonitis and fibrosis of Grade 1 and patient age, ipsilateral mean lung dose, volume of the ipsilateral lung receiving 20 Gy, and irradiation of the regional lymph nodes. In multivariate analysis, age and mean lung dose proved to be independent predictors of early (odds ratio [OR] = 1.035, 95% confidence interval [CI] 1.011-1.061 and OR = 1.113, 95% CI 1.049-1.181, respectively) and late (OR = 1.074, 95% CI 1.042-1.107 and OR = 1.207, 95% CI 1.124-1.295, respectively) radiogenic lung damage, whereas the role of systemic therapy was significant in the development of Grade 1 lung fibrosis (p = 0.01). Among the various forms of systemic therapy, tamoxifen increased the risk of late lung sequelae (OR = 2.442, 95% CI 1.120-5.326, p = 0.025). No interaction was demonstrated between the administration of systemic therapy and the other above-mentioned parameters as regards the risk of radiogenic lung damage. Conclusions: Our analyses demonstrate the independent role of concomitant tamoxifen therapy in the development of radiogenic lung fibrosis but do not suggest such an effect for the other modes of systemic treatment. Ó 2011 Elsevier Inc.Radiation lung sequelae, Tamoxifen, Aromatase inhibitors, Taxanes.

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“…Estrogens have also been suggested to be major regulators of wound repair, which may reverse age-related impaired wound healing in human and animal models (216,230,231). Estrogens dampen inflammation (as indicated by a suppression of the production of proinflammatory cytokines, macrophage migration inhibitory factor, and TNF-␣ by macrophages), and enhance the deposition of collagen I in the dermis, thus increasing the breaking strength of wounds in ovariectomized mice (232).…”

Section: Immunohistochemistry 28mentioning

confidence: 99%

The Hair Follicle as an Estrogen Target and Source

et al. 2006

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For many decades, androgens have dominated endocrine research in hair growth control. Androgen metabolism and the androgen receptor currently are the key targets for systemic, pharmacological hair growth control in clinical medicine. However, it has long been known that estrogens also profoundly alter hair follicle growth and cycling by binding to locally expressed high-affinity estrogen receptors (ERs). Besides altering the transcription of genes with estrogen-responsive elements, 17␤-estradiol (E2) also modifies androgen metabolism within distinct subunits of the pilosebaceous unit (i.e., hair follicle and sebaceous gland). The latter displays prominent aromatase activity, the key enzyme for androgen conversion to E2, and is both an estrogen source and target.Here, we chart the recent renaissance of estrogen research in hair research; explain why the hair follicle offers an ideal, clinically relevant test system for studying the role of sex steroids, their receptors, and interactions in neuroectodermal-mesodermal interaction systems in general; and illustrate how it can be exploited to identify novel functions and signaling cross talks of ER-mediated signaling. Emphasizing the long-underestimated complexity and species-, gender-, and site-dependence of E2-induced biological effects on the hair follicle, we explore targets for pharmacological intervention in clinically relevant hair cycle manipulation, ranging from androgenetic alopecia and hirsutism via telogen effluvium to chemotherapy-induced alopecia. While defining major open questions, unsolved clinical challenges, and particularly promising research avenues in this area, we argue that the time has come to pay estrogen-mediated signaling the full attention it deserves in future endocrinological therapy of common hair growth disorders. (Endocrine Reviews 27: 677-706, 2006)

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Oestrogens and wound healing

Cited by 53 publications

References 70 publications

Differential expression of steroid receptors in prostate tissues before and after radiation therapy for prostatic adenocarcinoma

Differential expression of steroid receptors in prostate tissues before and after radiation therapy for prostatic adenocarcinoma

Role of Systemic Therapy in the Development of Lung Sequelae After Conformal Radiotherapy in Breast Cancer Patients

The Hair Follicle as an Estrogen Target and Source

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