OEstrogenic Activity of Certain Synthetic Compounds

Dodds, E. C.; Goldberg, Leon I.; Lawson, W.; Robinson, Ross S.

doi:10.1038/141247b0

Cited by 488 publications

(171 citation statements)

References 6 publications

Supporting

Mentioning

166

Contrasting

Unclassified

Order By: Relevance

“…These effects, particularly those associated with endocrine disruption (Sumpter, 2009), have received much attention in the last decade. Endocrine disruption in the aquatic environment was first reported by Dodds et al (1938) and the impact of organic micropollutants and heavy metals have been known for number of years (Bedding et al 1982;Lester et al 1980) and have been the subject of legislation for an extensive period in the UK (Bedding et al 1983;Lester, 1983). However, there has been a need within the EU to update and harmonize existing legislation (EC, 2000(EC, , 2008(EC, , 2012 including regulations to control of the introduction of more recently recognized hazardous chemicals (Behera et al 2009;Gabriel et al 2012;González et al 2012;Martínez Bueno et al 2012;Martin Ruel et al 2012;Rodil et al 2012).…”

Section: Introductionmentioning

confidence: 99%

The significance of hazardous chemicals in wastewater treatment works effluents

Gardner

Comber

Scrimshaw

et al. 2012

Science of The Total Environment

124

View full text Add to dashboard Cite

The advent of increasingly stringent and wider ranging European Union legislation relating to water and the environment has required regulators to assess compliance risk and to respond by formulating appropriate pollution control measures. To support this process the UK Water Industry has completed a national Chemicals Investigation Programme (CIP), to monitor over 160 wastewater treatment works (WwTWs) for 70 determinands. Final effluent concentrations of zinc, polynuclear aromatic hydrocarbons (fluoranthene, benzo(a)pyrene, benzo(b)fluoranthene, benzo(k)fluoranthene, benzo(g,h,i)perylene and indeno(1,2,3-cd)pyrene), "penta" congeners (BDEs) 47 and 99, tributyltin, triclosan, erythromycin, oxytetracycline, ibuprofen, propranolol, fluoxetine, diclofenac, 17β-estradiol and 17α-ethinyl estradiol exceeded existing or proposed Environmental Quality Standards (EQSs) in over 50% of WwTWs. Dilution by receiving water might ensure compliance with EQSs for these chemicals, apart from the BDEs. However, in some cases there will be insufficient dilution to ensure compliance and additional management options may be required.

show abstract

Section: Introductionmentioning

confidence: 99%

The significance of hazardous chemicals in wastewater treatment works effluents

Gardner

Comber

Scrimshaw

et al. 2012

Science of The Total Environment

124

View full text Add to dashboard Cite

show abstract

“…Diethylstilbestrol (DES), a non-physiological estrogen, was developed in the late 1930s for clinical use and is thought to mimic the effect of estradiol (E2) (Dodds et al 1938). Subsequently, it was found that treatment of human fetuses and neonatal mice with DES as well as with physiological estrogens causes reproductive tract abnormalities and vaginal adenosis (Kimura et al 1967).…”

Section: Introductionmentioning

confidence: 99%

Similarities and differences in uterine gene expression patterns caused by treatment with physiological and non-physiological estrogens

Watanabe¹,

Suzuki²,

Kobayashi³

et al. 2003

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

Administration of physiological and non-physiological estrogens during pregnancy or after birth is known to have adverse effects on the development of the reproductive tract and other organs. Although it is believed that both estrogens have similar effects on gene expression, this view has not been tested systematically. To compare the effects of physiological (estradiol; E2) and non-physiological (diethylstilbestrol; DES) estrogens, we used DNA microarray analysis to examine the uterine gene expression patterns induced by the two estrogens. Although E2 and DES induced many genes to respond in the same way, different groups of genes showed varying levels of maximal activities to each estrogen, resulting in different dose-response patterns. Thus, each estrogen has a distinct effect on uterine gene expression. The genes were classified into clusters according to their dose-responses to the two estrogens. Of the eight clusters, only two correlated well with the uterotropic effect of different doses of E2. One of these clusters contained genes that were upregulated by E2, which included genes encoding several stress proteins and transcription factors. The other cluster contained genes that were downregulated by E2, including genes related to metabolism, transcription and detoxification processes. The expression of these genes in estrogen receptor-deficient mice was not affected by E2 treatment, indicating that these genes are affected by the E2-bound estrogen receptor. Thus, of the many genes that are affected by estrogen, it was suggested that only a small number are directly involved in the uterotropic effects of estrogen treatment.

show abstract

“…1 Over the next three decades, DES was administered to several million pregnant women in the United States and Europe. In 1971, a strong association was reported between DES and clear cell adenocarcinoma (CCA) of the vagina and cervix in young women.…”

mentioning

confidence: 99%

Cancer risk in women prenatally exposed to diethylstilbestrol

Troisi

Hatch

Titus-Ernstoff

et al. 2007

Intl Journal of Cancer

157

View full text Add to dashboard Cite

Prenatal diethylstilbestrol (DES) exposure is associated with excess risks of clear cell adenocarcinoma (CCA), and breast cancer in older women. Whether overall cancer risk is also elevated is unclear. Total and site-specific cancer risks were evaluated in the DES Combined Cohort Follow-up Study using age-and calendaryear specific standardized incidence rate ratios (SIR), and ageadjusted incidence rate ratios (RR) comparing DES exposed and unexposed women. A total of 143 and 49 cancer cases occurred in 97,831 and 34,810 person-years among the exposed and unexposed, respectively. There was no overall excess risk among exposed women when compared with external rates (SIR 1.01; 95% confidence interval [CI] 0.86-1.2). The overall RR comparing exposed with unexposed women was 1.32 (95% CI 0.94-1.8). Breast cancer risk was elevated only among women over 40 years (RR 1.83; 95% CI 1.1-3.2). The CCA SIR among exposed women was nearly 40, and the estimated attack rate through age 39 was 1.6/1,000 women. CCA incidence decreased by over 80% after age 25 when compared with 20-24 years. Excluding CCA and breast cancer, the overall RR was 1.21 (95% CI 0.74-2.0). DES was not associated with excess risks of either endometrial or ovarian cancer. These data suggest that the DES associated increase in CCA incidence remains elevated through the reproductive years. There was no consistent evidence of risk excesses for cancers other than CCA, and breast cancer in older women. Given that the population is still young, continued follow-up is necessary to assess the overall carcinogenic impact of prenatal DES exposure. ' 2007 Wiley-Liss, Inc.Key words: diethylstilbestrol; estrogen; cancer Diethylstilbestrol (DES), a potent synthetic estrogen, was first synthesized in 1938 and shortly thereafter promoted to prevent spontaneous abortion and premature delivery. 1 Over the next three decades, DES was administered to several million pregnant women in the United States and Europe. In 1971, a strong association was reported between DES and clear cell adenocarcinoma (CCA) of the vagina and cervix in young women. 2 Animal studies suggest the teratogenic and carcinogenic effects of prenatally administered DES may be due to changes in the expression of genes involved in the development of the reproductive tract 3 and raise concerns of elevated risk of other female reproductive tract cancers besides CCA.In the early 1990s, the National Cancer Institute (NCI) assembled new and previously established cohorts of DESexposed and unexposed individuals for combined follow-up. Baseline findings limited to analysis of the previously established cohorts showed DES was associated with an excess CCA risk and possibly with elevated breast cancer risk in older women, but did not indicate greater risk of endometrial or ovarian cancer. 4 More recent follow-up of the cohort for breast cancer incidence has shown a small but progressively increasing risk for DES exposure with age after 40. 5,6 To date, the follow-up experience of the combined cohort with regard to ove...

show abstract

OEstrogenic Activity of Certain Synthetic Compounds

Cited by 488 publications

References 6 publications

The significance of hazardous chemicals in wastewater treatment works effluents

The significance of hazardous chemicals in wastewater treatment works effluents

Similarities and differences in uterine gene expression patterns caused by treatment with physiological and non-physiological estrogens

Cancer risk in women prenatally exposed to diethylstilbestrol

Contact Info

Product

Resources

About