Oestrogen receptor β expression in pleomorphic adenomas of the parotid gland

Wong, Michelle; Dobbins, Timothy; Tseung, Jason; Tran, Nham; Lee, Cheok Soon; O’Brien, Christopher J.; Clark, Jonathan R.; Rose, Barbara

doi:10.1136/jcp.2009.065102

Cited by 15 publications

(14 citation statements)

References 37 publications

(47 reference statements)

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“…Overexpression of ER-β was described in four cases of pediatric MEC and in ACC cell line [ 32 ], while nuclear overexpression of ER-β was detected also in 71% of ACC FPPE tissues, with the average expressions higher in women, and in the cases with a cribriform architecture [ 11 ]. ERβ was also detected in several cases of PA of the salivary gland [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, the expression and role of AR in SGTs are well documented [ 9 , 10 ]. The other estrogen receptor (ERβ) was described in salivary gland adenocarcinoma cell lines and certain salivary gland carcinomas such as AdCC and Pleomorphic adenoma (PA) [ 11 , 12 ]. The structure of ERβ is homologous to that of ERα and its DNA-binding domain is 96% conserved compared to ERα, suggesting that ERβ could bind the same target genes [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Sex Hormone Receptors in Benign and Malignant Salivary Gland Tumors: Prognostic and Predictive Role

Aquino

Collina

Sabatino

et al. 2018

IJMS

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The role of sex hormone receptors in human cancer development and progression has been well documented in numerous studies, as has the success of sex hormone antagonists in the biological therapy of many human tumors. In salivary gland tumors (SGTs), little and conflicting information about the role of the estrogen receptor alpha (ERα), progesterone receptor (PgR) and androgen receptor (AR) has been described and in most cases the use of sex hormone antagonists is not contemplated in clinical practice. In this study, we analyzed a panel of sex hormone receptors that have not been widely investigated in SGTs—ERα, PgR, AR, but also ERβ and GPR30—to define their expression pattern and their prognostic and predictive value in a case series of 69 benign and malignant SGTs. We showed the aberrant expression of AR in mucoepidermoid and oncocytic carcinoma, a strong relation between cytoplasmic ERβ expression and tumor grade, and a strong correlation between nuclear GPR30 expression and disease-free survival (DFS) of SGT patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex Hormone Receptors in Benign and Malignant Salivary Gland Tumors: Prognostic and Predictive Role

Aquino

Collina

Sabatino

et al. 2018

IJMS

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“…As can be seen from the analysis of the archival data, the frequency of pleomorphic adenomas decreased in comparison with the statistics of the majority of foreign sources (according to EM Osipian, 2011; YH Matiakin 2010), the frequen cy of pleomorphic adenomas was 6190%) [13]. In turn, the domination of women in this neoplasm indicates a possible endocrine dependence of the tumour, namely the presence of oestrogen beta receptors in tumour tis sues [19]. Unlike women, for men the tumours of the sali vary glands were dominated by adenolymphomas (Warthin tumour), at 72.27%, which coincides with the data of most literary sources, in which the gender ratio (male : female) is between 3 : 1 and 5 : 1.…”

Section: Discussionmentioning

confidence: 99%

Analysis of archive material of patients with salivary gland neoplasms according to the department of O.O. Bogomolets National Medical University for the last five years

Brodetskyi¹,

Маланчук²

2019

jos

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Introduction: The frequency of salivary gland tumours remains high enough to date from 1% to 5% of all hu man tumours. Among benign tumours, pleomorphic adenomas dominate from 61% to 90%, and among malignant tumours, adenocarcinomas-20%. Objectives: The purpose of our research was to evaluate an analysis of archive material of patients with neo plasms of the salivary glands that were treated at the department of O.O. Bogomolets National Medical University in the last five years. Material and methods: The material for the survey were archival histories of 232 patients with neoplasms of the salivary glands. The average age of patients was 50 ± 15.3 years. All patients underwent general clinical exami nations. All patients were given a typical surgical intervention-excisional biopsy, partial, subtotal, or total parotidec tomy. Postoperative material passed the pathohistological study. Results: Analysis of archival histories of patients with neoplasms of the salivary glands in the period 20142018 shows that most of the pathohistological diagnoses were: pleomorphic adenomas 133 (57.32%), adenocarcinomas 48 (20.68%), and adenolymphomas (Warthin tumour) 33 (14.22%). The analysis of data on the distribution of patients by type of malignant tumours of the salivary glands showed that the largest number of patients was with mucoepidermoid cancer and acinic cell adenocarcinoma in 16 (33.33%) and 12 (25%) patients, respectively. Conclusions: In this article we discussed most of the statistics associated with salivary gland neoplasms, such as frequency of salivary gland tumours (benign and malignant), distribution of patients by gender and age, localisation of pathological process, noncoincidence of clinical and pathological diagnoses, histological types of pleomorphic adenomas, and their distribution depending on age and gender.

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“…Although oestrogen receptor α may be expressed in low levels in normal salivary tissue, it appears that oestrogen receptor β is the main oestrogen receptor in normal salivary tissue. A series of 49 pleomorphic adenomas showed that oestrogen receptor β was expressed in almost twice as many normal salivary tissues and pleomorphic adenomas as oestrogen receptor α [ 134 ]. Progesterone receptors do not appear to present in PAs [ 93 ].…”

Section: Genetics and Prognosismentioning

confidence: 96%

Pleomorphic Adenoma

Hellquist¹,

Skálová²

2014

Histopathology of the Salivary Glands

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Oestrogen receptor β expression in pleomorphic adenomas of the parotid gland

Abstract: This is thought to be the first study of ERbeta in pleomorphic adenomas of the salivary gland. Findings support ERbeta as the major ER in salivary glands, and provide evidence that ERbeta may have a role in the development of pleomorphic adenomas of the salivary gland.

Cited by 15 publications

References 37 publications

Sex Hormone Receptors in Benign and Malignant Salivary Gland Tumors: Prognostic and Predictive Role

Sex Hormone Receptors in Benign and Malignant Salivary Gland Tumors: Prognostic and Predictive Role

Analysis of archive material of patients with salivary gland neoplasms according to the department of O.O. Bogomolets National Medical University for the last five years

Pleomorphic Adenoma

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