Oestrogen receptor values and histological grade in human breast cancer

Abstract

Histological grading of 126 oestrogen receptor positive and 81 oestrogen receptor negative breast carcinomas, using the WHO system, showed that some tumours in all grades had high receptor values, others low. There was no correlation between the receptor values and histological grade. It is suggested that factors other than the degree of dedifferentiation of the tumour may be responsible for the consistent tendency for receptor negative tumours to be placed in a high histological grade.

The association of cytosol oestrogen and progesterone receptors with histological features of breast cancer and early recurrence of disease

“…The method of grading was not specified. In the present study, as in that of Heusen et al (1975) and Thoresen et al (1981), the mean value of the receptors was similar in all three grades, and thus the significance of the association between grade and presence or absence of receptor is difficult to interpret. Silvestrini et al (1979) incidence of REC.…”

“…recommended system of grading. More recently, using this method exclusively, ), Martin et al (1979b, Rasmussen et al (1981) and Thoresen et al (1981) have shown a definite relationship between histological grade and REC.…”

“…However, in some of these studies numbers were small and methods of REC analysis and morphological examination were inconsistent. More recent studies have shown that REC may be closely related to tumour grade Martin et al, 1979b;Rasmussen et al, 1981;Thoresen et al, 1981), to the histological type and degree of lymphocytic infiltration of primary tumour (Rosen et al, 1975) and to the presence or absence of elastosis in the tumour stroma (Masters et al, 1976). Similar links have been recognised between the progesterone receptor (RPc) and histological grade and elastosis (Martin et al, 1979b;Rolland et al, 1980), but a relationship between RPC and other aspects of tumour morphology has not been reported.…”

Does progesterone receptor in human breast cancer reflect the mast-cell content of the tumour tissue?

“…This is in keeping with lack of correlation between the actual RE values and other parameters (Thoresen et al, 1981).…”

The Changing Pattern of Recurrence in Oestrogen Positive and Negative Breast Cancer with Nodal Spread, Related to Efferent Vascular Invasion

“…ER analysis had been carried out on the primary tumours [5]. The latter had also been graded histologically [6] in association w'ith a further study [7], The EVI status had been recorded previously [3) the series being reduced to 55 cases in which this was possible. Since then 5 patients have died of causes unrelated to their breast disease.…”