Oestrogen, ocular function and low-level vision: a review

Hutchinson, Claire V.; Walker, James T.; Davidson, Charles S.

doi:10.1530/joe-14-0349

Cited by 33 publications

(31 citation statements)

References 93 publications

(99 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Physical functioning tasks affecting postural stability, postural orientation and balance involve complex inputs from somatosensory, vestibular and visual systems. Reduced visual input among those with poor vision leads to postural imbalance and falls by compromising the vestibulo-ocular reflex (22). In our study, measures of forward reach and timed stair climb, those most affected by postural stability and postural orientation were found to be associated with visual impairment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Visual impairment at baseline is associated with future poor physical functioning among middle-aged women: The Study of Women’s Health Across the Nation, Michigan Site

et al. 2017

View full text Add to dashboard Cite

Objectives Emerging evidence suggests that the prevalence rates of poor functioning and of disability are increasing among middle-aged individuals. Visual impairment is associated with poor functioning among older adults but little is known about the impact of vision on functioning during midlife. The objective of this study was to assess the impact of visual impairment on future physical functioning among middle-aged women. Study design In this longitudinal study, the sample consisted of 483 women aged 42 to 56 years, from the Michigan site of the Study of Women's Health Across the Nation. Main Outcome Measures At baseline, distance and near vision were measured using a Titmus vision screener. Visual impairment was defined as visual acuity worse than 20/40. Physical functioning was measured up to 10 years later using performance-based measures, including a 40-foot timed walk, timed stair climb and forward reach. Results Women with impaired distance vision at baseline had 2.81 centimeters less forward reach distance (95% confidence interval (CI): −4.19,−1.42) and 4.26 seconds longer stair climb time (95% CI: 2.73, 5.79) at follow-up than women without impaired distance vision. Women with impaired near vision also had less forward reach distance (2.26 centimeters, 95% CI: −3.30,−1.21) than those without impaired near vision. Conclusion Among middle-aged women, visual impairment is a marker of poor physical functioning. Routine eye testing and vision correction may help improve physical functioning among midlife individuals.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Second, the comorbidities known to affect physical functioning including angina, DM, HTN, stroke, and arthritis were added to the model. Third, menopausal status and hormone use were added to the models given known associations with physical functioning (22, 23). All covariates were measured concurrently with physical functioning assessment.…”

Section: Methodsmentioning

confidence: 99%

Visual impairment at baseline is associated with future poor physical functioning among middle-aged women: The Study of Women’s Health Across the Nation, Michigan Site

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Bovine and rat retinas have been shown to express estrogen receptors α and β throughout the retinal thickness [19-21, 24, 25], and estrogens have shown promise in influencing the natural history of retinitis pigmentosa, age-related macular degeneration and glaucoma as well as exercising neuroprotective properties against ischemia-reperfusion injury in the context of transient retinal ischemia [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Potential Effects of Hormone Therapy in Type 2 Idiopathic Macular Telangiectasia

et al. 2017

View full text Add to dashboard Cite

Purpose: To investigate the influence of hormone therapy with tamoxifen or estrogens on morphological changes in macular telangiectasia (MacTel) type 2 patients as revealed clinically in multiple imaging modalities. Methods: Patients with a history of tamoxifen or estrogen use were selected from the cohort of the MacTel Study. A race-, age- and best-corrected visual acuity-matched group of MacTel participants not under hormone therapy served as the comparison group. The frequencies of typical features of the MacTel phenotype apparent in color fundus, red-free, fluorescein angiographic and optical coherence tomographic images were graded and analyzed statistically. Results: Thirty-nine MacTel patients were included in the analyses, of whom 13 were receiving tamoxifen, 13 estrogens and 13 patients no hormone treatment. Patients treated with estrogens showed significantly fewer breaks in the ellipsoid zone on optical coherence tomography (7 eyes, 29.1%, vs. tamoxifen: 14 eyes, 53.8%, and vs. controls: 14 eyes, 53.8%, p = 0.04 in both analyses, Fisher exact test). Retinal crystalline deposits were significantly more frequent in patients receiving estrogens (12 eyes, 16.2%, vs. 2 eyes, 2.7%, p = 0.003, Fisher exact test). No significant between-group differences were apparent with regard to other features of the phenotype (extent of retinal low reflective spaces, late hyperfluorescence on fluorescein angiography or retinal thickness). Conclusions: Tamoxifen treatment does not seem to accentuate structural changes in patients with MacTel type 2. Treatment with estrogens may exhibit a neuroprotective effect as suggested by the decreased frequency of ellipsoid zone breaks in corresponding patients, although corroborative studies are warranted to confirm these exploratory data.

show abstract

“…Some well-known systemic conditions such as diabetes mellitus (DM) and systemic steroid intake promote cataract formation (1)(2)(3)(4) . Although it is controversial, some reports have shown the protective effect of estrogen against cataractogenesis (5,6) . Therefore, the decrease in estrogen level with the onset of menopause may increase the risk of cataract in women (5,6) .…”

Section: Introductionmentioning

confidence: 99%

“…Although it is controversial, some reports have shown the protective effect of estrogen against cataractogenesis (5,6) . Therefore, the decrease in estrogen level with the onset of menopause may increase the risk of cataract in women (5,6) . Oxidative damage is a major cause of cataract formation (7) .…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress of crystalline lens in rat menopausal model

Acer¹,

Pekel²,

Küçükatay³

et al. 2016

Arquivos Brasileiros De Oftalmologia

View full text Add to dashboard Cite

Purpose: To evaluate lenticular oxidative stress in rat menopausal models. Methods: Forty Wistar female albino rats were included in this study. A total of thirty rats underwent oophorectomy to generate a menopausal model. Ten rats that did not undergo oophorectomy formed the control group (Group 1). From the rats that underwent oophorectomy, 10 formed the menopause control group (Group 2), 10 were administered a daily injection of methylprednisolone until the end of the study (Group 3), and the remaining 10 rats were administered intraperitoneal streptozocin to induce diabetes mellitus (Group 4). Total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) measurements of the crystalline lenses were analyzed. Results: The mean OSI was the lowest in group 1 and highest in group 4. Nevertheless, the difference between the groups was not statistically significant in terms of OSI (p>0.05). The mean TOS values were similar between the groups (p>0.05), whereas the mean TAC of group 1 was significantly higher than that of the other groups (p<0.001). Conclusions:Our results indicate that menopause may not promote cataract formation.

show abstract

Oestrogen, ocular function and low-level vision: a review

Cited by 33 publications

References 93 publications

Visual impairment at baseline is associated with future poor physical functioning among middle-aged women: The Study of Women’s Health Across the Nation, Michigan Site

Visual impairment at baseline is associated with future poor physical functioning among middle-aged women: The Study of Women’s Health Across the Nation, Michigan Site

Potential Effects of Hormone Therapy in Type 2 Idiopathic Macular Telangiectasia

Oxidative stress of crystalline lens in rat menopausal model

Contact Info

Product

Resources

About