Oestrogen-dependent expression of LH/hCG receptors in pig Fallopian tube and their role in relaxation of the oviduct

Gawrońska, Barbara; Paukku, Tommi; Huhtaniemi, Ilpo; Wasowicz, G.; Ziȩcik, Adam J.

doi:10.1530/jrf.0.1150293

Cited by 56 publications

(64 citation statements)

References 24 publications

(33 reference statements)

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“…Helguera et al (2009) and Girotti and Zingg (2003) reported AQP5 and AQP8 expression in rat myometrium by microarray or quantitative RT-PCR (qRT-PCR) and by microarray, respectively. Immunohistochemical experiments performed by Gawronska et al (1999Gawronska et al ( , 2000 revealed luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptor protein expression in the epithelium of tubal mucosa, smooth muscle cells, and blood vessel endothelium in pigs. However, LH/hCG receptors in the mouse were detected in the serosa and subepithelial cells but not in the epithelium of the oviduct (Zhang et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Fluctuation of Aquaporin 1, 5, and 9 Expression in the Pig Oviduct during the Estrous Cycle and Early Pregnancy

Skowroński

Skowrońska

Nielsen

2011

J Histochem Cytochem.

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Thirteen mammalian aquaporin (AQPs) isoforms with a unique tissue-specific pattern of expression have been identified. To date, 11 isoforms of AQP have been reported to be expressed in female and male reproductive systems. The purpose of our study was to determine the localization and quantitative changes in the expression of AQP1, 5 and 9 within the pig oviduct during different stages of the estrous cycle and early pregnancy. The results demonstrated that AQP1, 5, and 9 were clearly detected in all studied stages of the estrous cycle and pregnancy. AQP1 was localized within oviductal blood vessels. In cyclic gilts, the expression of AQP1 protein did not change significantly between days 10–12 and 14–16 but increased on days 2–4 and 18–20. AQP5 was localized in smooth muscle cells and oviductal epithelial cells. The expression of AQP5 protein did not change significantly between days 10–12 and 14–16 of the estrous cycle but increased on days 2–4 and 18–20. The anti-AQP9 antibody labeled epithelial cells of the oviduct. The expression of AQP9 did not change significantly between days 10–12 and 14–16 of the estrous cycle but increased on days 2–4 and 18–20. In pregnant gilts, expression of AQP1, 5, and 9 did not change significantly in comparison with the estrous cycle. Therefore, a functional and distinctive collaboration seems to exist among diverse AQPs in water handling during the different oviductal phases in the estrous cycle and early pregnancy.

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Section: Discussionmentioning

confidence: 99%

Fluctuation of Aquaporin 1, 5, and 9 Expression in the Pig Oviduct during the Estrous Cycle and Early Pregnancy

Skowroński

Skowrońska

Nielsen

2011

J Histochem Cytochem.

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“…Receptors for LH have been identified in many extragonadal sites (Rao 2001), furthermore there is a compelling relationship between LH receptor expression and the sensitivity of the same site to oestrogen (Gawronska et al 1999) and expression of LH receptors has been linked to changes in oestrogen status in several species (Gawronska et al 1999;Akazome and Mori 1999;Knecht et al, 1984). Since bone-forming osteoblasts have been found to express receptors for estrogen (Komm et al 1988, Eriksen et al 1988) it was also a possibility that these same cells might also express receptors for LH.…”

Section: Discussionmentioning

confidence: 99%

“…Skin, mammary gland, uterus and urinary bladder express LH receptors and respond to changes in estrogen status. Of additional significance is the fact that estrogen can influence LH receptor expression and therefore the sensitivity of target tissues to this gonadotropin as observed, for example, in the epithelial tissue of the pig oviduct (Gawronska et al, 1999). Collectively, these findings imply that LH elicits a diverse array of cell and tissue responses other than ensuring the regulation of gonadal function.…”

Section: Introductionmentioning

confidence: 98%

Could bone tissue be a target for luteinizing hormone/chorionic gonadotropin?

Mansell

Bailey

Yarram

2007

Molecular and Cellular Endocrinology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A c c e p t e d M a n u s c r i p t Treatment of osteoblasts in culture with a urinary derived formulation of hCG resulted in increased alkaline phosphatase (ALP) activity, raised matrix mettaloproteinase-2 (MMP-2) levels and increased expression of type I collagen. Further studies, using murine calvaria, supported a bone-resorbing effect of hCG. Taken together our initial findings suggested that raised hCG and/or LH might lead to an overall increase in bone matrix turnover as reported for puberty, pregnancy and the menopause.However, when the urinary derived preparation of hCG was replaced with recombinant hormone no changes in osteoblast activity were found implying the presence of contaminating agents in the urine derived hCG. Herein we describe that epidermal growth factor (EGF) could account for the changes observed for urinary derived hCG in osteoblast cultures and that the effects of LH/hCG on bone tissue are probably indirect.

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“…by GnRH agonist or antagonist pretreatment, or by increasing the number of LHRs in the tumor e.g. by pre-treatment with estradiol (Gawronska et al 1999), could enhance the treatment outcome in granulosa cell tumors.…”

Section: In Vivo Trials Of Hecate-cgβ Conjugatementioning

confidence: 99%

Use of hecate–chorionic gonadotropin β conjugate in therapy of lutenizing hormone receptor expressing gonadal somatic cell tumors

Rivero-Müller¹,

Vuorenoja²,

Tuominen³

et al. 2007

Molecular and Cellular Endocrinology

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Oestrogen-dependent expression of LH/hCG receptors in pig Fallopian tube and their role in relaxation of the oviduct

Abstract: The current studies investigated the concentration and distribution of LH receptors in the oviduct of ovariectomized gilts at various times after administration of oestradiol benzoate (10 \g=m\gkg\m=-\1body weight) to

Cited by 56 publications

References 24 publications

Fluctuation of Aquaporin 1, 5, and 9 Expression in the Pig Oviduct during the Estrous Cycle and Early Pregnancy

Fluctuation of Aquaporin 1, 5, and 9 Expression in the Pig Oviduct during the Estrous Cycle and Early Pregnancy

Could bone tissue be a target for luteinizing hormone/chorionic gonadotropin?

Use of hecate–chorionic gonadotropin β conjugate in therapy of lutenizing hormone receptor expressing gonadal somatic cell tumors

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