Oestrogen and progesterone regulation of inflammatory processes in the human endometrium

King, Anne E.; Critchley, Hilary

doi:10.1016/j.jsbmb.2010.01.003

Cited by 111 publications

(102 citation statements)

References 173 publications

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“…Under the influence of this steroid hormone, the endometrium stops bleeding, the luminal lining re-epithelializes, the stromal tissue starts to grow, and vessels are repaired. After ovulation, during the secretory phase, cellular changes in the uterine endometrium that include the transformation and decidualization of the stromal cells and the development of secretory glandules are regulated by progesterone (Paria et al 2002, Dunn et al 2003, King & Critchley 2010.…”

Section: Inflammatory Events In the Endometriummentioning

confidence: 99%

Endometrial inflammation and effect on implantation improvement and pregnancy outcome

2012

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Implantation failure, which is presently the major barrier in human fertility, is attributed, in many cases, to the failure of the uterus to acquire receptivity. The transition into a receptive uterus includes cellular changes in the endometrium and the modulated expression of different cytokines, growth factors, transcription factors, and prostaglandins. These molecules partake in the generation of an inflammatory response followed by the recruitment of immune cells. These cells have shown to be involved in the maternal immune tolerance toward the implanted embryo as well as in the maternal-fetus interaction during pregnancy. Most of the accumulated evidence indicates that embryo implantation is associated with an active Th1 inflammatory response while a Th2-humoral inflammation is required for pregnancy maintenance. Yet, recent findings suggest that a Th1 inflammatory response is also necessary for the acquisition of uterine receptivity. This notion was originally suggested by reports from our and other clinical centers worldwide that IVF patients with repeated implantation failure subjected to endometrial biopsy exhibit a substantial improvement in their chances to conceive. These findings, followed by the demonstration of an elevated pro-inflammatory cytokine/chemokine expression, as well as an increased abundance of immune cells, in the endometrium of these patients, raised the idea that acquisition of uterine receptivity is closely associated with an inflammatory response. This review summarizes the molecular and biochemical evidence that confirm this notion and proposes a mechanism by which injury-induced inflammation improves uterine receptivity and the subsequent pregnancy outcome.Reproduction (2012) 144 661-668

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Section: Inflammatory Events In the Endometriummentioning

confidence: 99%

Endometrial inflammation and effect on implantation improvement and pregnancy outcome

2012

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“…Thus, it is interesting to speculate that PAD-mediated inflammatory activities may also play important roles in the female reproductive tract. For example, reproductive hormone-driven changes in the uterus can be viewed as an inflammatory process, as evidenced by the increased endometrial expression of inflammatory cytokines and chemokines and the accompanying infiltration of natural killer cells and other leucocytes into this tissue [72]. During the secretory phase of the estrous cycle, expression of the chemokines CXCL10 and CXCL11 by the human endometrium is high and appears to be regulated by both estradiol and progesterone [73].…”

Section: Could Pads Play a Role In Inflammation In The Female Reprodumentioning

confidence: 99%

Role for Peptidylarginine Deiminase Enzymes in Disease and Female Reproduction

2012

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“…Endometrial remodeling involves inflammatory factors like cytokines, chemokines and prostanoids (Jabbour et al, 2009). Estrogens regulate the inflammatory process in the endometrium which involves influx of leukocytes (King & Critchley, 2010). Infiltrating leukocytes not only provide protection against pathogens but also actively participate in the degradation and subsequent regeneration of endometrial tissue by secreting various proteases, cytokines and chemokines (Guo et al, 2011;.…”

Section: Reproductive Cyclementioning

confidence: 99%

Estrogen Receptors in Leukocytes - Possible Impact on Inflammatory Processes in the Female Reproductive System

Selvanesan¹

2011

Update on Mechanisms of Hormone Action - Focus on Metabolism, Growth and Reproduction

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Oestrogen and progesterone regulation of inflammatory processes in the human endometrium

Cited by 111 publications

References 173 publications

Endometrial inflammation and effect on implantation improvement and pregnancy outcome

Endometrial inflammation and effect on implantation improvement and pregnancy outcome

Role for Peptidylarginine Deiminase Enzymes in Disease and Female Reproduction

Estrogen Receptors in Leukocytes - Possible Impact on Inflammatory Processes in the Female Reproductive System

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