Oestradiol stimulates prolactin secretion in women through oestrogen receptors

Garas, Antonios; Trypsianis, Grigorios; Kallitsaris, A.; Milingos, S; Messinis, Ioannis E.

doi:10.1111/j.1365-2265.2006.02642.x

Cited by 6 publications

(1 citation statement)

References 31 publications

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“…Their precise physiological roles are not clear. It seems that the main pathway through which oestrogen stimulates prolactin secretion is through oestrogen receptors [24]. Elevated oestrogen levels can elucidate the hyperprolactinaemia.…”

Section: Discussionmentioning

confidence: 99%

Disorder in the Serotonergic System due to Tryptophan Hydroxylation Impairment: A Cause of Hypothalamic Syndrome?

Schött¹,

Nicolai

Vries

et al. 2010

Horm Res Paediatr

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Background: The hypothalamus regulates basic homeostasis such as appetite, circadian rhythm, autonomic and pituitary functions. Dysregulation in these functions results in the hypothalamic syndrome, a rare disorder of various origins. Since serotonin (5-HT) modulates most of the above-mentioned homeostasis, a defect in the serotonergic system can possibly participate in this syndrome. Methods: We describe a girl suffering from hypothalamic syndrome with a decreased concentration of 5-hydroxytryptophan (5-HTP) and a normal level of tryptophan in the cerebrospinal fluid (CSF) suggesting a functional defect in tryptophan hydroxylase (TPH). TPH is a rate-limiting enzyme in the synthesis of the neurotransmitter 5-HT. Results: Therapeutic intervention with 5-HTP, carbidopa and a specific serotonin reuptake inhibitor significantly improved her clinical symptoms and caused biochemical normalisation of neurotransmitters. Conclusion: The girl described had the typical symptoms of a hypothalamic disorder and a defective serotonergic metabolism, a relationship which has not been reported before. Therapeutic interventions to restore 5-HT metabolism resulted in clinical improvement. We suggest that investigation of 5-HT metabolism in CSF of patients with this rare disorder is included in the aetiological work-up.

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Section: Discussionmentioning

confidence: 99%