Oesophageal perforation following ingestion of over-the-counter ibuprofen capsules

Singh, Neeraj; Rizk, J G

doi:10.1017/s0022215108002582

Cited by 15 publications

(5 citation statements)

References 10 publications

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“…The typical endoscopic appearance of pill‐induced oesophageal injury is a discrete, punched‐out ulcer with relatively normal surrounding mucosa 128 . Ulcers may be single or multiple, and usually involve the mucosa only, although deeper degrees of penetration can occur, and localized perforation has been described 129,130 . Remnants of the pill may occasionally be identified at the site of injury 123…”

Section: Iatrogenic Oesophagitismentioning

confidence: 99%

Pathology of oesophagitis

Maguire

Sheahan

2011

Histopathology

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Endoscopic oesophageal biopsies are common in daily pathology practice. Inflammation and damage of the oesophageal mucosa is known as oesophagitis and is common worldwide. A variety of physical, chemical and infectious agents cause oesophagitis. The oesophagus has a limited range of responses to a wide variety of injuries, and so histopathological features of different diseases often overlap. The pathologist is reliant on the endoscopist for the 'macroscopic description' of the oesophagus. Access to the endoscopic images enhances the pathologist's overall interpretation of the case. Correlating clinical, endoscopic and microscopic findings may be crucial in arriving at the correct diagnosis. In this review, we present clinicopathological descriptions of the major types of oesophagitis.

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Section: Iatrogenic Oesophagitismentioning

confidence: 99%

Pathology of oesophagitis

Maguire

Sheahan

2011

Histopathology

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“…As the review by Kaul [ 2 ] mentioned, although the technical success rate can be upwards of 90%, up to 40-50% of patients may experience pain or other stent-related complications. As the studies by Veziant et al [ 1 ], Singh and Rizk [ 4 ], and Nassour and Fang [ 5 ] mentioned, the repair approach can range from open to minimally invasive. Despite a variety of approaches, esophageal perforation still carries a substantial morbidity and mortality rate, with 90-day mortality rates highest in those with a malignant etiology.…”

Section: Discussionmentioning

confidence: 99%

Breaking the Barrier: Understanding Esophageal Ruptures

Jamgochian,

Peters,

Kaur

et al. 2024

Cureus

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Esophageal rupture, though rare, presents as a critical medical emergency demanding swift recognition and intervention. This condition entails a breach in the integrity of the esophageal wall, leading to leakage of its contents into the mediastinum or surrounding structures. Its etiology often involves a combination of factors, including forceful vomiting, foreign body ingestion, or medical procedures like endoscopy. Timely diagnosis through imaging modalities like CT scans, contrast esophagography, or endoscopy is crucial for prompt management and favorable outcomes. Offering aggressive care in the setting of futile treatment for esophageal perforations raises several ethical, medical, and practical implications. If the prognosis is deemed futile due to factors such as extensive tissue damage, underlying comorbidities, or delayed presentation, aggressive care may only prolong suffering without meaningful improvement in outcomes. Opting for palliative measures in such cases focuses on enhancing the patient's quality of life and providing comfort rather than pursuing futile treatments.

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“…In einer Studie aus Großbritannien konnte gezeigt werden, dass ein Histamin-Rezeptor-Antagonist (H2-Blocker, hier "Famotidin"), einmal täglich genommen, signifikant das Risiko der Entwicklung eines Ulkus- leidens und der Entstehung einer erosiven Ösophagitis bei Patienten mit Low-dose-Aspirin-Einnahme mindern kann [14]. In einem Case Report wird sogar von einer Ösophagusperforation durch NSAR (Ibuprofen) bei einem 18-jährigen sonst gesunden Mann berichtet [15].…”

Section: öSophagusunclassified

NSAR-Wirkungen auf den Gastrointestinaltrakt

Schick¹,

Schulz²

2010

Endo heute

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Oesophageal perforation following ingestion of over-the-counter ibuprofen capsules

Cited by 15 publications

References 10 publications

Pathology of oesophagitis

Pathology of oesophagitis

Breaking the Barrier: Understanding Esophageal Ruptures

NSAR-Wirkungen auf den Gastrointestinaltrakt

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