Oesophageal carcinoma

Pennathur, Arjun; Gibson, Michael K.; Jobe, Blair A.; Luketich, James D.

doi:10.1016/s0140-6736(12)60643-6

Cited by 2,202 publications

(1,925 citation statements)

References 129 publications

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“…Generally, the standard of care for patients with locoregional ESCC involves neoadjuvant chemoradiation followed by response assessment and observation or surgical resection [1][2][3][4][8][9][10][11]. To date, there are no approved targeted therapies for ESCC, and recurrence rates remain high for locoregional disease [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences

Wang¹,

Johnson²,

Ali³

et al. 2015

The Oncologist

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Background. Esophageal squamous cell carcinomas (ESCCs) and esophageal adenocarcinomas (EACs) account for .95% of esophageal malignancies and represent a major global health burden. ESCC is the dominant histology globally but represents a minority of U.S. cases, with EAC accounting for the majority of U.S. cases.The patient outcomes for advanced ESCC and EAC are poor, and new therapeutic options are needed. Using a sensitive sequencing assay, we compared the genomic profiles of ESCC and EAC with attention to identification of therapeutically relevant genomic alterations. Methods. Next-generation sequencing-based comprehensive genomic profiling was performed on hybridization-captured, adaptor ligation-based libraries to a median coverage depth of .6503 for all coding exons of 315 cancer-related genes plus selected introns from 28 genes frequently rearranged in cancer.Results from a single sample were evaluated for all classes of genomic alterations (GAs) including point mutations, short insertions and deletions, gene amplifications, homozygous deletions, and fusions/rearrangements. Clinically relevant genomic alterations (CRGAs) were defined as alterations linked to approved drugs and those under evaluation in mechanismdriven clinical trials.Results. There were no significant differences by sex for either tumor type, and the median age for all patients was 63 years.

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Section: Introductionmentioning

confidence: 99%

Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences

Wang¹,

Johnson²,

Ali³

et al. 2015

The Oncologist

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“…Esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer worldwide (2). ESCC tends to have a poor prognosis due to high rates of lymph node metastasis and invasion into surrounding organs (2).…”

Section: Introductionmentioning

confidence: 99%

“…ESCC tends to have a poor prognosis due to high rates of lymph node metastasis and invasion into surrounding organs (2). ESCC has been identified to harbor frequent somatic mutations in tumor protein 53 (3), Notch homolog 1, tumor protein P53 (3) and phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit α (4).…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of ZNF750 gene expression, a novel tumor suppressor gene, in esophageal squamous cell carcinoma

et al. 2017

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Abstract. The present authors previously identified a novel candidate tumor suppressor gene, zinc finger protein 750 (ZNF750), in esophageal squamous cell carcinoma (ESCC) (1). The present study aimed to clarify the clinical significance of ZNF750 expression in ESCC. The association between ZNF750 DNA mutation status and the mRNA expression was examined by whole exome sequence analysis and quantitative reverse transcription polymerase chain reaction (RT-qPCR). The expression of ZNF750 in 76 patients with ESCC (Kyushu University Beppu Hospital) was measured using immunohistochemistry and RT-qPCR. Using this dataset, the association between ZNF750 mRNA expression and clinicopathological factors was examined. Additionally, survival analysis was performed using datasets from the Kyushu University Beppu Hospital and The Cancer Genome Atlas (TCGA). The biological effects of ZNF750 expression were explored using gene set enrichment analysis (GSEA) and were validated using datasets from the Cancer Cell Line Encyclopedia (CCLE) and the Kyushu University Beppu Hospital. ZNF750 expression analyses demonstrated that ZNF750 mRNA expression was lower in patients with the DNA mutations compared with those without the mutations (P<0.05), and ZNF750 expression was downregulated in tumor tissues compared with normal tissues (P<0.00005). In the clinicopathological analysis, the low ZNF750 expression group exhibited a higher incidence of undifferentiated histology (P<0.05) compared with the high expression group. The low ZNF750 expression group exhibited a poorer prognosis in the Kyushu and TCGA datasets (P<0.0005 and P<0.05, respectively). GSEA indicated that ZNF750 expression was significantly correlated with epithelial differentiation in ESCC. This was confirmed using the datasets from CCLE and the Kyushu University Beppu Hospital by analyzing the levels of small proline rich protein 1A mRNA, an epithelial differentiation-associated gene. In conclusion, the results of the present study suggested that ZNF750 serves a role as a tumor suppressor; potentially via regulating epithelial differentiation and that it may be a promising biomarker of poor outcomes in ESCC.

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“…With a five-year survival rate between 15 and 25%, oesophageal cancer poses an immense burden of disease globally [2,3].…”

Section: Introductionmentioning

confidence: 99%

Obesity and Oesophageal Cancer

Nimptsch

Steffen

Pischon

2016

Recent Results in Cancer Research

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(150-250 words)A substantial increase in the incidence of oesophageal adenocarcinoma has been observed in western countries during the past 30 years, which may be related to the parallel rise of the obesity prevalence. On the other hand, incidence rates of oesophageal squamous cell carcinomas, the other major histological type of oesophageal cancer, have remained relatively stable.Epidemiological research of the past decades has identified obesity as risk factor for oesophageal adenocarcinoma. Studies investigating general obesity as assessed by body mass index provide evidence for a strong positive association with oesophageal adenocarcinoma. Studies investigating abdominal obesity in relation to oesophageal adenocarcinoma observed also positive associations, which may be independent of general obesity. Some studies indicate that early life obesity is also associated with higher risk of oesophageal adenocarcinoma, but it is as to date unclear whether these associations are independent of adult obesity. Part of the positive association between obesity and oesophageal adenocarcinoma may be explained through obesityrelated mechanical promotion of gastrooesophageal reflux disease, which is one of the main risk factors for oesophageal adenocarcinoma. Other lines of evidence point to an independent role of metabolic pathways modulating cell proliferation, apoptosis and cell growth such as proinflammatory cytokines, adipokines and insulin resistance, the role of which in oesophageal carcinogenesis is, however, as to date insufficiently understood. Studies investigating obesity in 2 relation to squamous cell carcinoma observed inverse relationships, but the underlying mechanisms remain unclear.

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Oesophageal carcinoma

Cited by 2,202 publications

References 129 publications

Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences

Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences

Clinical significance of ZNF750 gene expression, a novel tumor suppressor gene, in esophageal squamous cell carcinoma

Obesity and Oesophageal Cancer

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