Oesophageal cancer presenting as Lemierre’s syndrome caused by<i>Streptococcus anginosus</i>

Hasan, Saqib; Bachuwa, Ghassan

doi:10.1136/bcr-2017-219661

Cited by 14 publications

(12 citation statements)

References 26 publications

(6 reference statements)

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“…Since the initial symptom was intense dysphagia, the evacuation of the abscess was performed at first. Subsequently, upper digestive endoscopy was performed and esophageal cancer was discovered [56]. Other authors present the first case of proximal esophageal adenocarcinoma located in the thyroid in a young patient without any history of neoplasms [57].…”

mentioning

confidence: 99%

Differential Diagnosis in Esophageal Cancer. Review on literature

Popa¹,

Badiu²,

Andronache³

et al. 2019

Rev. Chim.

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Esophageal cancer represents a neoplasm that is thought to have both an increased incidence and prevalence in the following years. Although much progress has been made in the detection and the early treatment of esophageal cancer, the prognosis is still limited, and mortality remains very high. The most common histological types of esophageal cancer are squamous cell carcinoma, and, respectively, adenocarcinoma. Lately, there has been an accelerated increase in the incidence of adenocarcinoma, in the context of increased prevalence of gastro-esophageal reflux disease and obesity, but also of the current alimentary diet, especially in developed countries. The esophagus has its anatomical features. Moreover, it is located topographicallyin a complex cervico-thoraco-abdominal area, unique for a viscus. From the clinical point of view, the onset of symptoms of esophageal cancer is insidious. For these reasons, special attention should be pain in the early detection and differentiation of this neoplasm from other pathologies. These pathologies are very varied and may comprise other esophageal diseases, neighborhood pathologies such as cervical, thoracic, abdominal, systemic pathologies (immunologic, infectious) or other pathologies such as the oro-maxillo-facial, oculo-orbital, vascular, muscular, and cutaneous ones. Keywords: esophagus, cancer, differential diagnosis

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mentioning

confidence: 99%

Differential Diagnosis in Esophageal Cancer. Review on literature

Popa¹,

Badiu²,

Andronache³

et al. 2019

Rev. Chim.

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“…We found that 9 out of 16 patients did see a healthcare provider (56%) with one of them having been previously hospitalized before being transferred to another facility. and 9 of those 10 patients received antibiotics (56%) [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] .…”

Section: Discussionmentioning

confidence: 99%

Lemierre’s syndrome: Case report and brief literature review

Zhao

Samannodi²,

Tahir³

et al. 2017

IDCases

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Lemierre’s syndrome has been shown to be increasing in incidence in the past 20 years with one popular suggesting that said rise occurred from less aggressive antibacterial coverage. We report a case of Lemierre’s syndrome and also reviewed the 15 most recent case reports. A previously healthy 25 year old male who initially developed sore throat and flu-like symptoms, was prescribed antibacterials as an outpatient but was hospitalized for worsening symptoms. He was later diagnosed with Lemierre’s syndrome and improved clinically with IV antimicrobials alone. From our concise literature review, we determined that a decrease in antibiotic prescriptions may not fully explain why the incidence of Lemierre’s has been increasing. Thus, future research should be focused in evaluating possible worsening susceptibilities to antibiotics and improvements on detection. We also advise physicians to be aware of the signs and symptoms of this rare but potentially fatal condition as well as the available detection methods and treatment

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“…Whether these are truly causative agents, or F. necrophorum undetected, remains unknown. 13,14 Importantly, differences in the definition of the diagnostic criteria of Lemierre syndrome do not ultimately translate to different diagnostic and therapeutic approaches.…”

Section: Casementioning

confidence: 99%

Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis

et al. 2018

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Lemierre syndrome usually affects otherwise healthy adolescents or young adults and occurs at an overall rate of 1 to 10 cases per million person-years with an estimated fatality rate of 4 to 9%. Diagnostic criteria remain debated and include acute neck/head bacterial infection (often tonsillitis caused by anaerobes at high potential for sepsis and vascular invasion, notably Fusobacterium necrophorum) complicated by local vein thrombosis, usually involving the internal jugular vein, and systemic septic embolism. Medical treatment is based on antibiotic therapy with anaerobic coverage, anticoagulant drugs and supportive care in case of sepsis. Surgical procedures can be required, including drainage of the abscesses, tissue debridement and jugular vein ligation. Evidence for clinical management is extremely poor in the absence of any adequately sized study with clinical outcomes. In this article, we illustrate two cases of Lemierre syndrome not caused by Fusobacterium necrophorum and provide a clinically oriented discussion on the main issues on epidemiology, pathophysiology and management strategies of this disorder. Finally, we summarize the study protocol of a proposed systematic review and individual patient data meta-analysis of the literature. Our ongoing work aims to investigate the risk of new thromboembolic events, major bleeding or death in patients diagnosed with Lemierre syndrome, and to better elucidate the role of anticoagulant therapy in this setting. This effort represents the starting point for an evidence-based treatment of Lemierre syndrome built on multinational interdisciplinary collaborative studies.

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Oesophageal cancer presenting as Lemierre’s syndrome caused byStreptococcus anginosus

Cited by 14 publications

References 26 publications

Differential Diagnosis in Esophageal Cancer. Review on literature

Differential Diagnosis in Esophageal Cancer. Review on literature

Lemierre’s syndrome: Case report and brief literature review

Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis

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