Oesophageal atresia

Lennep, Marinde van; Singendonk, Maartje; Dall’Oglio, Luigi; Gottrand, Frédéric; Krishnan, Usha; Terheggen-Lagro, Suzanne W. J.; Omari, Taher; Benninga, Marc A.; Wijk, Michiel P. van

doi:10.1038/s41572-019-0077-0

Cited by 104 publications

(96 citation statements)

References 228 publications

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“…In our study, dysphagia was the main complaint. Dysphagia is often caused by delayed esophageal clearance due to disturbed motility [22] . Surprisingly, GER was not addressed as a problem.…”

Section: Body Functions and Structuresmentioning

confidence: 99%

Patient-driven healthcare recommendations for adults with esophageal atresia and their families

Kate¹,

Rietman

Kamphuis³

et al. 2021

Journal of Pediatric Surgery

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Section: Body Functions and Structuresmentioning

confidence: 99%

Patient-driven healthcare recommendations for adults with esophageal atresia and their families

Kate¹,

Rietman

Kamphuis³

et al. 2021

Journal of Pediatric Surgery

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“…On the other hand, these diseases are associated with a relatively high incidence of short-term and long-term complications after surgery which can also seriously affect the quality of life. Examples include fecal and urinary incontinence and sexual inadequacy after repair of high-type anorectal malformation ( 11 ), anastomotic stricture, long-term gastrointestinal, and respiratory complications and comorbidities after repair of long gap esophageal atresia ( 12 ), and short bowel syndrome after repair multiple intestinal atresia ( 13 ). When parents comprehend the course of treatment and the long-term prognosis of the diseases, many parents state that they cannot tolerate the repeated surgical procedures and the uncertain therapeutic effects, especially when the newborn is burdened with multiple malformations.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and Reasons for Discharge Against Medical Advice for Newborns With Neonatal Surgical Diseases: A Preliminary Study From a Tertiary Care Hospital in Beijing, China

et al. 2020

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Background: To identify the risk factors and reasons for discharge against medical advice (DAMA) for newborns with neonatal surgical diseases in a tertiary care hospital in China. Methods: A retrospective study was conducted on all newborn patients admitted to the neonatal surgery department of Beijing Children's Hospital between January 1, 2016 and January 1, 2020. Medical records were compared between DAMA and non-DAMA patients. Univariate and multivariate logistic regression analyses were conducted to identify potentially useful characteristics for predicting DAMA. Results: During the study period, 854 newborns were admitted to the neonatal surgery department. A total of 68 DAMA patients (68/854, 7.96%, 47 boys), with a median age at diagnosis of 1 day (range, from birth to 21 days), were included in this study. After multivariate analysis, we found that emergency admission, age at admission ≤5 days, rejection for surgery, and admission to the neonatal intensive care unit were significant independent risk factors for DAMA. According to the electronic medical records, the reasons for DAMA included belief in incurability and concerns about the prognosis of the disease ( n = 31), multiple malformations with poor prognosis ( n = 8), severe postoperative complications ( n = 5), financial difficulties ( n = 3), refusal of further examinations ( n = 2), assumption of clinical improvement ( n = 1), and unknown ( n = 18). Conclusions: This preliminary study showed that neonatal surgical patients in critical conditions were high-risk groups for DAMA, and the main possible reasons for DAMA were the parents' belief in incurability and concerns about the prognosis of the disease.

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“…The occurrence of anastomotic stula is mainly related to anastomotic blood supply, anastomotic tension and other factors [9,10]. The incidence of anastomotic stula after end-to-end oesophagostomy is reported to be approximately 8-12% in adults [11], and the incidence of anastomotic stula after EA is approximately 20% [3]. This may be related to the large anastomotic tension and poor anastomotic blood supply caused by oesophageal defects.…”

Section: Risk Factor Analysis Of Recent Anastomotic Stulamentioning

confidence: 99%

“…At present, this disease is believed to be due to the interruption of oesophageal continuity caused by abnormal development of the preembryonic intestinal area. Approximately 70-90% of children often have tracheal oesophageal stula (TEF) [2], and 55% of children may have other systemic congenital malformations, especially severe heart malformations, which is an important factor for poor prognosis in children [3]. The treatment of EA has made great progress in the past 20 years, and the survival rate can reach more than 90%.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Anastomotic Complications After One-stage Anastomosis for Oesophageal Atresiarisk Factors for Anastomotic Complications After One-stage Anastomosis for Oesophageal Atresia

Huang¹,

Hong²,

Chen³

et al. 2020

Preprint

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Objective: The objective of this study is to identify the risk factors for anastomotic complications after one-stage anastomosis for oesophageal atresia.Methods: A retrospective analysis was performed on the clinical data of 107 children with congenital oesophageal atresia who underwent one-stage anastomosis in our hospital from January 2016 to December 2018. Single-factor and multivariate logistic regression analyses were performed to determine the risk factors for anastomotic fistula and anastomotic stenosis.Results: A total of 107 children with oesophageal atresia underwent one-stage anastomosis, and the incidence of anastomotic fistula was 26.2%. The probability of anastomotic stenosis in the long term was 52.3%, and the incidence of refractory stenosis (dilation ≥5 times) was 13.1%. Analysis of the clinical count data in the anastomotic fistula group and non-anastomotic fistula group showed that preoperative albumin (F=4.199, P=0.043), low birth weight (F=7.668, P=0.007) and long gap defects (F=6.107, P=0.015) were risk factors for postoperative anastomotic fistula. Further multivariate logistic regression analysis showed that low birth weight (Wald2=4.499, P =0.034, OR=2.775) and long gap defects (Wald2=6.769, P =0.009, OR=4.939) were independent risk factors for postoperative anastomotic fistula. Premature delivery (F=5.338, P=0.023), anastomotic fistula (F=11.381, P=0.001), endoscopic surgery (F=6.343, P=0.013), preoperative neutrophil count (F=8.602, P=0.004), preoperative low albumin (F=8.410, P=0.005), and a preoperative prognostic nutritional index < 54 (F=5.54, P=0.02) were risk factors for long-term anastomotic stenosis in children. Further multivariate logistic regression analysis showed that postoperative anastomotic fistula (Wald2=11.417, P =0.001, OR=8.798), endoscopic surgery (Wald2=9.633, P =0.002, OR=4.808), and a prognostic nutritional index < 54 (Wald2=4.540, P =0.002, OR=2.3798) were independent risk factors for long-term anastomotic stenosis.Conclusion: Low birth weight and long gap defects are important predictors of postoperative anastomotic fistula, and the possibility of long-term anastomotic stenosis should be considered. The long-term risk of anastomotic stenosis was increased in children undergoing endoscopic surgery and in those with a preoperative prognostic nutritional index < 54.

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Oesophageal atresia

Cited by 104 publications

References 228 publications

Patient-driven healthcare recommendations for adults with esophageal atresia and their families

Patient-driven healthcare recommendations for adults with esophageal atresia and their families

Risk Factors and Reasons for Discharge Against Medical Advice for Newborns With Neonatal Surgical Diseases: A Preliminary Study From a Tertiary Care Hospital in Beijing, China

Risk Factors for Anastomotic Complications After One-stage Anastomosis for Oesophageal Atresiarisk Factors for Anastomotic Complications After One-stage Anastomosis for Oesophageal Atresia

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