Oesophageal Adenocarcinoma Presenting with Multiple Streptococcus intermedius Cerebral Abscesses

Hanna, Michael E.; Das, Debasish

doi:10.1007/s12029-013-9522-6

Cited by 7 publications

(5 citation statements)

References 11 publications

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“…In the only other case of brain abscess secondary to S. intermedius, Hanna and Das report a patient with multiple abscesses and esophageal adenocarcinoma [2]. Our patient also presented with brain abscess, except with squamous cell carcinoma in place of adenocarcinoma.…”

Section: Discussionmentioning

confidence: 54%

“…Brain abscesses occur when an organism seeds the brain parenchyma, leading to purulence and inflammation in one or more localized regions [2]. Three mechanisms for the development of intracerebral abscesses have been proposed: (1) direct extension from contiguous structures such as the teeth, middle ear, sinuses, or mastoid via venous circulation; (2) hematogenous spread from other sites such as the GI tract, heart, or lungs; and (3) following neurosurgical procedures or penetrating trauma to the skull [3].…”

Section: Introductionmentioning

confidence: 99%

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Esophageal Squamous Cell Carcinoma Presenting with Streptococcus intermedius Cerebral Abscess

Nayfe

Ascha

Rehmus

2017

Case Reports in Pathology

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Background Cerebral abscess is caused by inoculation of an organism into the brain parenchyma from a site distant from the central nervous system. Streptococcus intermedius (S. intermedius) is a commensal organism that is normally present in the aerodigestive tract and was reported to be the cause of brain abscesses after esophageal dilatation or upper endoscopy. Case Presentation We report the case of a 53-year-old female who presented with hematemesis and melena followed by left-sided weakness. Initially, her hemiplegia was found to be secondary to a right thalamic brain abscess caused by S. intermedius. Investigations led to the diagnosis of a mid-esophageal squamous cell carcinoma. We hypothesize that the cause of the abscess with this bacterium that naturally resides in the digestive tract and oral cavity is secondary to hematogenous spread from breach in the mucosal integrity from ulceration due to the cancer. Conclusion To our knowledge, our case is the first in the literature to describe a brain abscess caused by S. intermedius in association with a previously undiagnosed esophageal squamous cell carcinoma without any prior esophageal intervention.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Esophageal Squamous Cell Carcinoma Presenting with Streptococcus intermedius Cerebral Abscess

Nayfe

Ascha

Rehmus

2017

Case Reports in Pathology

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“…Bacterial migration from esophageal dilation and cancer has been reported as a cause of brain abscesses. 10 - 12 Hanna and Das 10 and Nayfe et al 11 reported 2 cases of brain abscesses caused by Streptococcus intermedius in association with esophageal adenocarcinoma and squamous cell carcinoma, respectively. To the best of our knowledge, our case is the first in the literature to describe brain abscesses caused by Streptococcus intermedius in association with esophageal perforation of unknown etiology.…”

Section: Discussionmentioning

confidence: 99%

Esophageal Perforation Presenting Initially as Multiple Brain Abscesses Secondary to Streptococcus intermedius

Swied,

Alom,

Daaboul

et al. 2024

Journal of Investigative Medicine High Impact Case Reports

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Brain abscess is a life-threatening infection that can occur secondary to contiguous or hematogenous spread. Several underlying conditions can lead to brain abscesses, such as dental infection, otitis media, sinusitis, and immunosuppression. Esophageal perforation leading to brain abscesses is extremely rare. We report a rare case of a 32-year-old man who presented to the emergency department with progressive headaches and upper-extremity weakness. Upon further evaluation, computed tomography (CT) revealed multiple brain abscesses secondary to Streptococcus intermedius infection. The patient eventually underwent esophagogastroduodenoscopy (EGD), which showed a perforation in the middle third of the esophagus. This case highlights the importance of considering esophageal perforation as a predisposing condition for brain abscesses.

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“…The remainder of the cases identified in our literature search were cancer patients who developed S. intermedius abscesses but who had not received radiation treatment. [8][9][10][11][12][13][14][15][16][17][18][19][20][21] One of these patients, like our patient, had tonsillar squamous cell carcinoma; however, this patient presented with a neck abscess before cancer diagnosis. 12…”

Section: Review Of Existing Literaturementioning

confidence: 99%

A Case of Streptococcus intermedius Abscess Within a Malignant Neck Mass and Review of the Literature

Cummins¹,

Lin

2021

Infect Dis Clin Pract

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Streptococcus intermedius is an organism found commensally in various mucosal sites. Over the past couple decades, it has been recognized as a cause of severe pyogenic infections in sites including the brain, liver, lung, head and neck. Here, we describe an uncommon case of S. intermedius infection in a patient with tonsillar squamous cell carcinoma and a metastatic neck mass with overlying postradiation skin changes. We also review the literature on this pathogen in cancer patients because it remains understudied despite its pathogenicity.

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Oesophageal Adenocarcinoma Presenting with Multiple Streptococcus intermedius Cerebral Abscesses

Cited by 7 publications

References 11 publications

Esophageal Squamous Cell Carcinoma Presenting with Streptococcus intermedius Cerebral Abscess

Esophageal Squamous Cell Carcinoma Presenting with Streptococcus intermedius Cerebral Abscess

Esophageal Perforation Presenting Initially as Multiple Brain Abscesses Secondary to Streptococcus intermedius

A Case of Streptococcus intermedius Abscess Within a Malignant Neck Mass and Review of the Literature

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