Oerskovia xanthineolytica bacteremia in an Immunocompromised patient with pneumonia

McDonald, L. Clifford; Chapin-Robertson, Kimberle; Dill, S; Martino, Roy L.

doi:10.1016/0732-8893(94)90029-9

Cited by 18 publications

(16 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Case reports of human infections include endocarditis (O. turbata [355]), meningitis (O. xanthineolytica [222]), endophthalmitis (O. xanthineolytica [209]), infection of a prosthetic joint (O. xanthineolytica [196]), catheter-related bacteremia (O. turbata, O. xanthineolytica [248,260,279,428]), bacteremia caused by contaminated total parenteral nutrition solution (Oerskovia sp. [190]), gangrenous cholecystitis after endoscopic retrograde cholangiopancreaticography (O. xanthineolytica [150]), CAPD peritonitis (O. xanthineolytica [366]), pyonephrosis (NMO [95]), and soft tissue infection (O. xanthineolytica [150]).…”

Section: Genus Oerskoviamentioning

confidence: 99%

Clinical microbiology of coryneform bacteria

et al. 1997

View full text Add to dashboard Cite

Coryneform bacteria are aerobically growing, asporogenous, non-partially-acid-fast, gram-positive rods of irregular morphology. Within the last few years, there has been a massive increase in the number of publications related to all aspects of their clinical microbiology. Clinical microbiologists are often confronted with making identifications within this heterogeneous group as well as with considerations of the clinical significance of such isolates. This review provides comprehensive information on the identification of coryneform bacteria and outlines recent changes in taxonomy. The following genera are covered: Corynebacterium, Turicella, Arthrobacter, Brevibacterium, Dermabacter. Propionibacterium, Rothia, Exiguobacterium, Oerskovia, Cellulomonas, Sanguibacter, Microbacterium, Aureobacterium, "Corynebacterium aquaticum," Arcanobacterium, and Actinomyces. Case reports claiming disease associations of coryneform bacteria are critically reviewed. Minimal microbiological requirements for publications on disease associations of coryneform bacteria are proposed.

show abstract

Section: Genus Oerskoviamentioning

confidence: 99%

Clinical microbiology of coryneform bacteria

et al. 1997

View full text Add to dashboard Cite

show abstract

“…In vitro, they have exhibited resistance to a range of antimicrobials: penicillins, aminoglycosides, macrolides, and cephalosporins. They were reported as resistant (or intermediate) to erythromycin in many reports, although specific antibiotics and the methods by which resistance was assessed varied (3,5,10,19,23,26,28,32). This is expected, since resistance to erythromycin and other macrolides is high among aerobic and facultative anaerobic, non-spore-forming grampositive bacilli (29).…”

mentioning

confidence: 99%

“…The API Coryne biochemical strip (BioMerieux) keyed out with the number 7572727, an excellent identification for "Oerskovia xanthineolytica," which is now known as Cellulosimicrobium cellulans. The API Coryne strip has proved useful in identification of this species and other coryneforms (7) and was used for identification in many of the reports reviewed (4,10,14,17,19,23). We attempted to confirm this identification with further tests which distinguish Cellulosimicrobium cellulans from Oerskovia turbata.…”

mentioning

confidence: 99%

Clearance of Cellulosimicrobium cellulans Bacteremia in a Child without Central Venous Catheter Removal

Rowlinson¹,

Bruckner²,

Hinnebusch³

et al. 2006

J Clin Microbiol

View full text Add to dashboard Cite

Cellulosimicrobium cellulans (formerly known as Oerskovia xanthineolytica) rarely causes human infection. Infections have been reported in immunocompromised hosts or in patients with foreign bodies, such as catheters, where treatment has generally involved removal of the foreign body. We report on a case in which the organism was isolated in multiple blood cultures from a 13-year-old male. After initial therapy failed, treatment with vancomycin and rifampin resulted in infection clearance without removal of the central venous catheter. CASE REPORTA 13-year-old male with a history of midgut volvulus and subsequent short-bowel syndrome, who had received total parenteral nutrition since shortly after birth, presented to the Emergency Department at the University of California-Los Angeles with fever of 39°C, malaise, and bilateral conjunctivitis. The patient had had numerous urinary tract infections and central venous catheter (CVC) line infections in the last few years with organisms such as Micrococcus, coagulase-negative Staphylococcus, Staphylococcus aureus, and Enterococcus species. In the emergency room, blood was drawn from the CVC and from a peripheral vein. Both specimens grew pleomorphic gram-positive rods in aerobic and anaerobic blood culture bottles that were identified as Cellulosimicrobium cellulans. The patient was hospitalized and initially treated with intravenous vancomycin and cefotaxime, which was changed 2 days later to vancomycin and gentamicin. After 3 days in the hospital, the patient became afebrile and was discharged home to continue intravenous vancomycin therapy. Blood cultures (drawn on hospital day 2) became positive for Cellulosimicrobium cellulans after 72 h. Because the patient had been discharged, he was readmitted even though he was afebrile. Due to the difficulty of finding another line of intravenous access for this patient, an attempt to preserve the CVC was made by adding oral rifampin to the treatment regimen. Once rifampin was begun, subsequent blood cultures (drawn 2, 3, and 5 days after readmission, respectively) were negative. The patient was discharged home to complete therapy of 3 weeks on intravenous vancomycin and oral rifampin. A repeat culture obtained 72 h after discontinuation of antibiotics was negative. The patient has not had any recurrent infections with this organism and continues to use the CVC line on a daily basis (1 year posttherapy).

show abstract

“…Based on disk diffusion and broth dilution testing to determine minimum inhibitory concentrations (MICs), Oerskovia appears to be most susceptible to vancomycin (MIC<0.5) and TMP/SMX (MIC=0.5) (11, 12). Beta‐lactam agents are often resistant in vitro (penicillin MIC=1.5–2, ampicillin MIC=4, ceftriaxone MIC=24); clindamycin has MIC=2 (11). There are no reports of synergy testing to date.…”

Section: Treatmentmentioning

confidence: 99%

Oerskovia xanthineolytica endocarditis in a renal transplant patient: case report and review of the literature

Urbina

Gohh

Fischer

2003

Transplant Infectious Dis

View full text Add to dashboard Cite

Oerskovia species were, until recently, only rarely associated with human disease. This gram-positive bacillus can be easily misidentified as a diphtheroid, a common contaminant in blood cultures. There have been 17 reports of invasive Oerskovia infection in immunocompromised hosts. We report a case of Oerskovia xanthineolytica endocarditis in a renal transplant patient and review the microbiologic and clinical characteristics of this potential pathogen.

show abstract

Oerskovia xanthineolytica bacteremia in an Immunocompromised patient with pneumonia

Cited by 18 publications

References 7 publications

Clinical microbiology of coryneform bacteria

Clinical microbiology of coryneform bacteria

Clearance of Cellulosimicrobium cellulans Bacteremia in a Child without Central Venous Catheter Removal

Oerskovia xanthineolytica endocarditis in a renal transplant patient: case report and review of the literature

Contact Info

Product

Resources

About