Odynophagia from Aphthous Ulcers of the Pharynx and Esophagus in the Acquired Immunodeficiency Syndrome (AIDS)

Bach, Michael C.; Valenti, August J.; Howell, Douglas A.; Smith, Thomas J.

doi:10.7326/0003-4819-109-4-338

Cited by 90 publications

(15 citation statements)

References 3 publications

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“…This further undermines the hypothesis that aphthous ulceration may be related to systemic overproduction of TNF-a [2]. Aphthous ulceration of the oral cavity and esophagus responds to treatment with immune modulators, such as thalidomide [2,3] and prednisone [8]; therefore, it is likely that the cause of this form of ulceration is immunologic. However, the exact immunologic mechanism has yet to be discovered.…”

Section: Discussionmentioning

confidence: 96%

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Thalidomide in Low Intermittent Doses Does Not Prevent Recurrence of Human Immunodeficiency Virus–Associated Aphthous Ulcers

et al. 2001

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A multicenter, double-blind, randomized, placebo-controlled study was conducted to determine the safety and efficacy of thalidomide in reduced, intermittent doses for preventing recurrences of oral and esophageal aphthous ulcers in patients with human immunodeficiency virus (HIV) infection. Forty-nine HIV-infected patients whose ulcers previously had healed as a result of thalidomide therapy were randomly assigned to receive either 100 mg of oral thalidomide or placebo 3 times per week for 6 months. Ulcers recurred in 14 (61%) of 23 thalidomide-randomized patients, compared with 11 (42%) of 26 placebo-randomized patients, with no significant difference in the median time to recurrence of ulcers (P=.221). There were no changes in plasma levels of HIV RNA, tumor necrosis factor (TNF)-alpha, and soluble TNF receptor II at the time of ulcer recurrence. Adverse events among patients treated with thalidomide included neutropenia (5 patients), rash (5 patients), and peripheral sensory neuropathy (3 patients). Thalidomide in lower intermittent doses is ineffective at preventing recurrence of aphthous ulcers in HIV-infected persons.

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Section: Discussionmentioning

confidence: 96%

“…Results of uncontrolled studies have shown that topical, intralesional, and systemic corticosteroids heal aphthous ulceration in HIV-infected patients [8]. However, the relapse rate with this form of treatment is substantial as well.…”

Section: Discussionmentioning

confidence: 99%

Thalidomide in Low Intermittent Doses Does Not Prevent Recurrence of Human Immunodeficiency Virus–Associated Aphthous Ulcers

et al. 2001

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“…Other manifestations include dysphagia, substernal chest pain, and burning sensation independent of oral intake. 5 The ulcers can be single or multiple, are usually large and often longitudinal distal lesions which are commonly surrounded by erythema, edema, with overhanging edges. 2,5 Diagnosis is dependent upon esophagoscopy with biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…5 The ulcers can be single or multiple, are usually large and often longitudinal distal lesions which are commonly surrounded by erythema, edema, with overhanging edges. 2,5 Diagnosis is dependent upon esophagoscopy with biopsy. 6 Idiopathic esophageal ulcers associated with AIDS are differentiated from other esophageal ulcers by the failure to identify pathogens that can produce similar endoscopic findings (i.e., cytomegalovirus, herpes simplex virus).…”

Section: Discussionmentioning

confidence: 99%

Letter to the Editor: Idiopathic Esophageal Ulcers in an AIDS Patient Resulting in a Stricture

Borum¹,

Marks²

2000

AIDS Patient Care and STDs

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“…Some patients have responded to treatment with oral prednisone[95][96][97]. Occasionally, a granular appearance re-ing [91]; three of the patients had concurrent infection with Candida.…”

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confidence: 99%

Dysphagia in systemic disease

1993

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Dysphagia, difficulty in swallowing sometimes accompanied by a sensation of food sticking, is a common symptom resulting from structural and/or motility disorders of the oropharynx and esophagus which may result from local factors or occur as one of the manifestations of a systemic disease process. In this review, "systemic disease" will include diseases that affect more than one organ or organ system in the body such as scleroderma or Crohn's disease; skin disorders such as epidermolysis bullosa dystrophica and benign mucosal pemphigoid; hematological disorders such as amyloid and irondeficiency anemia; connective tissue disorders such as rheumatoid arthritis, dermatomyositis, polymyositis, and mixed connective tissue disorder; metabolic and endocrine disorders such as diabetes mellitus, sarcoidosis, and the Eaton-Lambert syndrome; and the immune-compromised host, and finally medications will all be addressed.The discussion will specifically exclude diseases that produce dysphagia by local inflammation (such as erosive esophagitis due to gastroesophageal reflux) or local infiltration (such as pharyngeal or esophageal carcinoma). Similarly, diseases which affect specific areas of the brain (such as a cerebrovascular accident or brain tumor) will be excluded as will neuromuscular diseases such as myasthenia gravis and amyotrophic lateral sclerosis.

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Odynophagia from Aphthous Ulcers of the Pharynx and Esophagus in the Acquired Immunodeficiency Syndrome (AIDS)

Cited by 90 publications

References 3 publications

Thalidomide in Low Intermittent Doses Does Not Prevent Recurrence of Human Immunodeficiency Virus–Associated Aphthous Ulcers

Thalidomide in Low Intermittent Doses Does Not Prevent Recurrence of Human Immunodeficiency Virus–Associated Aphthous Ulcers

Letter to the Editor: Idiopathic Esophageal Ulcers in an AIDS Patient Resulting in a Stricture

Dysphagia in systemic disease

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