Odour perception in chronic renal disease

Griep, Martijn; Niepen, Patricia Van der; Sennesael, Jacques; Mets, Tony; Massart, D.L.; Verbeelen, Dierik

doi:10.1093/ndt/12.10.2093

Cited by 63 publications

(67 citation statements)

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“…However, ID and DIS tests were signiWcantly reduced as well in our patients even to a lower amount than THR. In addition, renal insuYciency has been shown to alter olfactory function [31][32][33][34]. Although 31.25% of the patients in this study had renal involvement by WG (classical WG), there was no signiWcant diVerence in smell and taste function when compared with those without renal aVectation.…”

Section: Discussionmentioning

confidence: 62%

Evaluation of smell and taste in patients with Wegener’s granulomatosis

Fasunla

Hundt

Lutz

et al. 2011

Eur Arch Otorhinolaryngol

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Although a reduced olfactory/gustatory function affects patients in all parts of life, this problem has not received much attention in Wegener's granulomatosis (WG). The aim of this study was to assess the smell/taste function of WG patients. Demographic data of 16 WG patients (9 males, 7 females) were obtained. They all subjectively assessed their taste/smell function on visual analogue scale. Olfactory/gustatory functions of the patients were tested with 'Sniffin' Sticks and 'Taste' strips, respectively. The results were then compared with those from sex and age-matched control group (n = 16) and normative data. WG patients subjectively assessed their olfactory (p = 0.03) and gustatory (p = 0.02) function to be lower than control group. All the olfactory scores (odour identification, odour discrimination and threshold) in both genders were significantly below the scores in the control group. WG patients were hyposmic. For taste (total taste score, as well as scores for the qualities sweet, sour, salty and bitter), WG patients did not significantly differ from controls and were normogeusic. However, the gustatory scores showed the tendency of reduction as compared to the control group. In conclusion, WG patients truly suffer from olfactory/taste dysfunction, but this is worse with olfaction. It is, therefore, imperative that physicians should make their patients to be aware of these sensory dysfunctions and educate them on methods to cope with it for better quality of life.

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Section: Discussionmentioning

confidence: 62%

Evaluation of smell and taste in patients with Wegener’s granulomatosis

Fasunla

Hundt

Lutz

et al. 2011

Eur Arch Otorhinolaryngol

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“…As with taste, left posterior insular stroke can lead to increased sensitivity to smell contralateral to the lesion (Mak et al 2005), and olfactory disorders occur in end-stage liver disease (Bloomfeld et al 1999). Furthermore, the sense of smell is severely impaired in chronic renal failure (Griep et al 1997).…”

Section: Critical Illnessmentioning

confidence: 99%

Critical illness and changes in sensory perception

Schiffman

2007

Proc. Nutr. Soc.

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Impairments of sensory perception that occur during a period of critical care can seriously impact on health and nutritional status, activities of daily living, independence, quality of life and the possibility of recovery. It is emphasized from the outset that sensory losses in criticallyill patients may or may not be related to their current medical condition. The present paper provides an overview of all five senses (vision, hearing, taste, smell and touch) and describes the factors that contribute to sensory losses in critically-ill patients, including medications, medical conditions and treatments and the process of aging itself. Cancer and stroke are two critical illnesses in which profound sensory decrements often occur. Many sensory complaints in patients with cancer are related to alteration in sensory signals caused by damage to the sensory receptors. However, some complaints, such as taste aversions in patients with cancer, are not related to altered sensory physiology per se but to learned aversions that arise during the noxious effects of radiotherapy and chemotherapy. The paper also reviews a study in which the sensory performance (of all five senses) was compared in three groups of elderly subjects: (1) patients who had undergone coronary artery bypass surgery; (2) patients with cardiovascular conditions but with no history of surgery; (3) healthy non-medicated age-matched controls. Performance of patients who had undergone coronary artery bypass surgery was worse than that for the other two groups, with taste and smell losses greater than for the other senses. The study demonstrates that critical illness (e.g. coronary artery bypass surgery) can exacerbate sensory losses in an older cohort.

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“…Of significant interest is the finding that odor perception is either the same or worse immediately after hemodialysis but fully restored to that of normal controls after renal transplantation. [15][16][17] This finding suggests that reduced olfactory function in ESRD is due to uremic toxins not adequately cleared with current dialysis techniques but fully reversible with complete resolution of the uremic state.…”

Section: Introductionmentioning

confidence: 98%

“…5-11 Alterations in taste and smell have also been identified in uremic patients but their relationship to malnutrition is unclear. [12][13][14][15][16][17][18] Normal olfaction is required for full appreciation of the smell and taste of food. Among elderly people in the general population poor odor perception is associated with lower nutrient intake.…”

Section: Introductionmentioning

confidence: 99%

“…19 Research into olfactory function in ESRD is limited. [13][14][15][16][17][18] Few correlations of olfactory function and nutritional status have been reported. Of significant interest is the finding that odor perception is either the same or worse immediately after hemodialysis but fully restored to that of normal controls after renal transplantation.…”

Section: Introductionmentioning

confidence: 99%

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Relationship of Impaired Olfactory Function in ESRD to Malnutrition and Retained Uremic Molecules

Raff

Lieu

Melamed

et al. 2008

American Journal of Kidney Diseases

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Background-Olfactory function is impaired in patients with end stage renal disease (ESRD) and may contribute to uremic anorexia. Only limited correlations of olfactory function and nutritional status have been reported. This study examined the relationship of impaired olfactory function to malnutrition and levels of the retained uremic solutes monomethylamine, ethylamine, indoxyl sulfate, and P-cresol sulfate

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Odour perception in chronic renal disease

Cited by 63 publications

References 0 publications

Evaluation of smell and taste in patients with Wegener’s granulomatosis

Evaluation of smell and taste in patients with Wegener’s granulomatosis

Critical illness and changes in sensory perception

Relationship of Impaired Olfactory Function in ESRD to Malnutrition and Retained Uremic Molecules

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