Abstract:Aversion to novel stimuli in autism affects quality of life. We developed a behavioral paradigm to study the effect of novel background odors on odor discrimination in mouse models of autism. We trained wild type mice to discriminate target odors in known background odors. When tested, mice could discriminate known targets in novel background odors, a task similar to the visual CAPTCHA used to distinguish humans from computers. Using glomerular imaging data, we showed that WT mice used an algorithm that requir… Show more
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