Odor identification impairment in autism spectrum disorder might be associated with mitochondrial dysfunction

Yang, Rushi; Zhang, Ge; Shen, Yidong; Ou, Jianjun; Liu, Yanan; Huang, Lian; Zeng, Ying; Lin, Jingjing; Liu, Ruiting; Wu, Renrong; Xia, Kun; Zhang, Fengyu; Zhao, Jingping

doi:10.1016/j.ajp.2022.103072

Cited by 7 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Emerging evidence of mitochondrial dysfunction in FOXP1 +/− mice suggested that inadequate energy supply and excessive oxidative stress underlie cognitive and motor impairments caused by FOXP1 deficiency ( Wang et al, 2022 ). In addition, odor identification impairment in ASD may be associated with mitochondrial dysfunction ( Yang et al, 2022 ). The mitochondria are involved in astrocyte maturation and synapse formation.…”

Section: Mitochondria and Methylation May Be Involved In The Regulati...mentioning

confidence: 99%

Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder

Xiong

Chen

2023

Front. Neurosci.

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with onset in childhood. The mechanisms underlying ASD are unclear. In recent years, the role of microglia and astrocytes in ASD has received increasing attention. Microglia prune the synapses or respond to injury by sequestrating the injury site and expressing inflammatory cytokines. Astrocytes maintain homeostasis in the brain microenvironment through the uptake of ions and neurotransmitters. However, the molecular link between ASD and microglia and, or astrocytes remains unknown. Previous research has shown the significant role of microglia and astrocytes in ASD, with reports of increased numbers of reactive microglia and astrocytes in postmortem tissues and animal models of ASD. Therefore, an enhanced understanding of the roles of microglia and astrocytes in ASD is essential for developing effective therapies. This review aimed to summarize the functions of microglia and astrocytes and their contributions to ASD.

show abstract

Section: Mitochondria and Methylation May Be Involved In The Regulati...mentioning

confidence: 99%

Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder

Xiong

Chen

2023

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Indeed, it has been suggested that olfaction may provide a novel early nonverbal, non-task-dependent ASD marker, as well as serve in ASD intervention [187]. Moreover, recent investigations indicate that impairment in odor identification in ASD appears to be associated with mitochondrial dysfunction [188], another anomaly strongly linked to ASD [189] (Figure 1).…”

Section: Apap-epigenetics-asdmentioning

confidence: 99%

Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder

Csoka,

El Kouhen,

Bennani

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by severe deficits in social communication and interaction, repetitive movements, abnormal focusing on objects, or activity that can significantly affect the quality of life of the afflicted. Neuronal and glial cells have been implicated. It has a genetic component but can also be triggered by environmental factors or drugs. For example, prenatal exposure to valproic acid or acetaminophen, or ingestion of propionic acid, can increase the risk of ASD. Recently, epigenetic influences on ASD have come to the forefront of investigations on the etiology, prevention, and treatment of this disorder. Epigenetics refers to DNA modifications that alter gene expression without making any changes to the DNA sequence. Although an increasing number of pharmaceuticals and environmental chemicals are being implicated in the etiology of ASD, here, we specifically focus on the molecular influences of the abovementioned chemicals on epigenetic alterations in neuronal and glial cells and their potential connection to ASD. We conclude that a better understanding of these phenomena can lead to more effective interventions in ASD.

show abstract

“…The olfactory system is also impaired in patients with ASD, with deficits in odor identification, odor sensitivity, and odor preference that vary in degree depending on the complexity of the disorder (Crow et al, 2020 ; Lyons-Warren et al, 2021 ; Yang et al, 2022 ). However, the detection seems to not be altered (Lyons-Warren et al, 2021 ).…”

Section: Part 2: Importance Of the Oxytocinergic System In The Sensor...mentioning

confidence: 99%

Modulation of the thermosensory system by oxytocin

Zayan

Prato

Muscatelli

et al. 2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Oxytocin (OT) is a neurohormone involved early in neurodevelopment and is implicated in multiple functions, including sensory modulation. Evidence of such modulation has been observed for different sensory modalities in both healthy and pathological conditions. This review summarizes the pleiotropic modulation that OT can exercise on an often overlooked sensory system: thermosensation. This system allows us to sense temperature variations and compensate for the variation to maintain a stable core body temperature. Oxytocin modulates autonomic and behavioral mechanisms underlying thermoregulation at both central and peripheral levels. Hyposensitivity or hypersensitivity for different sensory modalities, including thermosensitivity, is a common feature in autism spectrum disorder (ASD), recapitulated in several ASD mouse models. These sensory dysregulations occur early in post-natal development and are correlated with dysregulation of the oxytocinergic system. In this study, we discussed the potential link between thermosensory atypia and the dysregulation of the oxytocinergic system in ASD.

show abstract

Odor identification impairment in autism spectrum disorder might be associated with mitochondrial dysfunction

Cited by 7 publications

References 18 publications

Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder

Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder

Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder

Modulation of the thermosensory system by oxytocin

Contact Info

Product

Resources

About