Odontogenic tumour of lip

A calcifying epithelial odontogenic tumor of Pindborg was examined with the electron microscope. The tumor cells demonstrated fine structural features commonly seen in epidermal cells, i.e., intercellular bridges with desmosomes, intracytoplasmic tonofilaments, and well‐developed hemidesmosomes. A thin linear condensation was observed within die lamina lucida of hemidesmosomes which probably represents a normal component of these attachments. A copious extracellular matrix was seen which was composed largely of fine fibrils, approximately 50 Å in width, aggregated to form a structure resembling a basal lamina. The possibility that this fibrillar extracellular matrix represents amyloid was discussed. Calcospherites were present within the matrix, occasionally in association with fragmented tumor cell cytoplasm. They appeared to lack collagen and were composed primarily of electron dense needles resembling hydroxyapatite.

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Calcifying epithelial odontogenic tumor of pindborg.An electron microscopic study

Anderson

Kim

Minkowitz

1969

Cancer

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Calcifying epithelial odontogenic tumor. A histochemical and ultrastructural study

Chaudhry

Hanks

Leifer

et al. 1972

Cancer

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The tissue representing calcifying epithelial odontogenic tumor was taken from the posterior mandible of a 45‐year‐old Caucasian man. The histologic components of the tumor were: 1. sheets of polyhedral epithelial cells, 2. homogeneous substance, and 3. dystrophic calcification. The homogeneous substance reacted metachromatically to methyl and crystal violet and fluoresced yellow following Thioflavin T. However, it stained equivocally for amyloid with Congo red, and exhibited weak birefringence with polarized microscope and yellow fluorescence. The homogeneous substance consisted of densely packed microfibrils, 50–150 Ä in diameter, deposited within, as well as between, the tumor cells. Since the ultrastructural characteristics of the fibrillar material were unlike amyloid associated with the reticuloendothelial cells, it is postulated that the epithelial tumor cells may be producing some other fibrillar protein such as keratin or enamel matrix.

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Ultrastructural study of amyloid material in the calcifying epithelial odontogenic tumor

Page

Weiss

Eggleston

1975

Cancer

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A typical calcifying epithelial odontogenic tumor of the maxilla was examined with the electron microscope. The tumor cell resembles the ameloblast at an early stage of enamel deposition. Formation of extracellular amyloid masses probably proceeds both by active cellular secretion and cell death, each process adding similar granulofibrillar material to these masses, which tend to calcify. The amyloid masses are probably a relatively homogeneous protein material and represent a specific tumor cell product. Further characterization of this neoplasm must include chemical and physical studies of this extracellular tumor product, which is an amyloid material because of classic staining characteristics.

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Odontogenic tumour of lip

Cited by 9 publications

References 7 publications

Calcifying epithelial odontogenic tumor of pindborg.An electron microscopic study

Calcifying epithelial odontogenic tumor of pindborg.An electron microscopic study

Calcifying epithelial odontogenic tumor. A histochemical and ultrastructural study

Ultrastructural study of amyloid material in the calcifying epithelial odontogenic tumor

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