Odontogenic myxofibroma arising in an elderly male: cell kinetics of epithelium and stroma

Tsukinoki,; Yasuda,; Shimamura,; Osamura,; Itoh,; Watanabe,

doi:10.1046/j.1365-2559.1999.0781b.x

Cited by 5 publications

(10 citation statements)

References 5 publications

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“…These results showing the presence of CCN2 protein in the tumor may also be consistent with our previous report stating that CCN2 transcripts are spatiotemporally expressed in the odontogenic mesenchyme, odontogenic epithelium, and dental follicle in developing tooth germs []. However, the density of odontogenic epithelial cells within the odontogenic mesenchymal structure like tumor is usually very low, and the occurrence of odontogenic epithelial nests has been reported to be 0 or 10.7% [,]. In the present case, odontogenic epithelial nest cells were not present in the tumor tissue, and the amount of collagen in the mucoid stroma was prominent.…”

Section: Discussionsupporting

confidence: 93%

Expression and roles of CCN2 in dental mesenchymal cells in primary culture—With findings in a case of odontogenic myxofibroma

Shimo

Koyama

Horikiri

et al. 2013

Oral Science International

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a b s t r a c tPurpose of the research: Tooth germ development involves multiple events, including cell proliferation and cell differentiation. Connective tissue growth factor (CTGF/CCN2) is a signaling protein involved in tooth germ development, and we investigated how it is expressed and what roles it may have in primary cultures of mesenchymal cells derived from the developing tooth germ. We also examined the expression of CCN2 in a human odontogenic myxofibroma, a benign tumor of odontogenic mesenchymal origin, and considered the possible roles of CCN2 in the development of myxofibromas. Materials and methods: Mesenchymal cells of early bell-stage tooth germs were isolated from Day-90 bovine embryos and placed in primary culture. A resected specimen from a patient with odontogenic myxofibroma was prepared for immunohistochemical studies. Principal results: The CCN2 expression level in proliferating odontogenic mesenchymal cells freshly isolated from the early bell stage of developing bovine tooth germs and placed in primary culture was 3 times higher than that in the confluent non-proliferating cells. Recombinant CCN2 significantly increased the proliferation and type I collagen expression in odontogenic mesenchymal cells in primary culture. Immunohistochemical analysis on myxofibroma case revealed that CCN2 was detectable in MIB-1, a cellular marker of proliferation-positive odontogenic mesenchymal cells adjacent to capillary blood vessels and in the endothelial cells of the vessels in the tumor. Major conclusion: CCN2 signaling would influence the proliferation of and extracellular matrix production by dental mesenchymal cells. Our results suggest that the same mechanisms of CCN2 action toward dental mesenchymal cells would also be operative in the odontogenic myxofibroma microenvironment.

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Section: Discussionsupporting

confidence: 93%

Expression and roles of CCN2 in dental mesenchymal cells in primary culture—With findings in a case of odontogenic myxofibroma

Shimo

Koyama

Horikiri

et al. 2013

Oral Science International

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“…Recently, it has been reported that over expression of Bcl-2 protein exhibits the inhibition of apoptosis found on odontogenic epithelium, and over expression of Bcl-2 protein is presumed to participate in the development and evaluation of odontogenic lesions (11). On the other hand, the review of growth activity has extreme significance in the assessment of the development of tumors (12). So, to find out biological behaviors of the calcifying odontogenic cyst in our case, we compared the expression of Bcl-2 protein and growth activity.…”

Section: Discussionmentioning

confidence: 99%

Calcifying odontogenic cyst associated with complex and compound odontoma: Report of a case and immunohistochemical study.

et al. 2001

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A case of calcifying odontogenic cyst associated with complex and compound odontoma which appeared in the maxilla of a 15-year-o1d Japanese girl was reported with immunohistological examination. Radiologically, the lesion showed a cystic radiolucent area with odontoma-like radiopaque masses. Histopathological examination revealed the presence of ghost cells, calcified tissues and structures of complex and compound odontoma. Immunohistochemically, MIB-1 positive ratio was very low, but significant expression of Bcl-2 was observed in the neoplastic odontogenic epithelium. These results suggest that inhibition of apoptotic cell loss is more important than cell proliferation activity to the growth of the lesion in our case.

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“…Expression of involucrin was observed in the spinal layer, but not in the basal layer in the epithelium of the graft. On the other hand, the expression of Ki‐67 (as a proliferation marker) (25) was located in the basal and parabasal cell layers. Because normal differentiation and proliferation in the squamous epithelium of the graft was evident, it was suggested that the squamous epithelium of the graft retained human characteristics rather than mouse characteristics.…”

Section: Discussionmentioning

confidence: 99%

In vivo experimental model of human gingival mucosa using immunodeficient mice

Tsukinoki

Miyoshi

Aoki

et al. 2007

J of Periodontal Research

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Odontogenic myxofibroma arising in an elderly male: cell kinetics of epithelium and stroma

Cited by 5 publications

References 5 publications

Expression and roles of CCN2 in dental mesenchymal cells in primary culture—With findings in a case of odontogenic myxofibroma

Expression and roles of CCN2 in dental mesenchymal cells in primary culture—With findings in a case of odontogenic myxofibroma

Calcifying odontogenic cyst associated with complex and compound odontoma: Report of a case and immunohistochemical study.

In vivo experimental model of human gingival mucosa using immunodeficient mice

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