Odontogenic Keratocysts and Nevoid Basal Cell Carcinoma Syndrome

McClatchey, Kenneth D.; Batsakis, John G.; Hybels, Roger L.; Wieren, Clare R. Van

doi:10.1001/archotol.1975.00780390027007

Cited by 10 publications

(3 citation statements)

References 8 publications

(1 reference statement)

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“…This study has confirmed previous statements that patients with NBS cannot be identified by routine bistological examination of basal cell carcinomas , McClatchey et al 1975.…”

Section: Discussionsupporting

confidence: 91%

The nevoid basal cell carcinoma syndrome

Lindeberg

Jepsen

1983

J Cutan Pathol

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126 basal cell carcinomas from 7 patients with nevoid basal cell carcinoma syndrome were examined histologically and--using a scoring system--compared with 54 solitary basal cell carcinomas. The solid subtype formed 78.9% of all tumors in the head and neck region and 48.9% of those located elsewhere. A broader spectrum of histological subtypes was noticed in tumors from patients with the syndrome. As multiple, keratinizing odontogenic and epidermal cysts are often seen in the nevoid basal cell carcinoma syndrome it was interesting to see that multiple keratinizing cysts within skin tumors were recorded more often in this group.

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“…This study has confirmed previous statements that patients with NBS cannot be identified by routine bistological examination of basal cell carcinomas , McClatchey et al 1975.…”

Section: Discussionsupporting

confidence: 91%

The nevoid basal cell carcinoma syndrome

Lindeberg

Jepsen

1983

J Cutan Pathol

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“…'7 Ovarian fibromas were first documented in NBCCS in 1964'4 and have been estimated to occur in up to 75% of all NBCCS patients attending a gynaecology department.5 No accurate estimate of their true prevalence in the NBCCS population has been possible. We have been able to assess this as occurring in between 12 and 24% of patients. The tumours are usually totally asymptomatic as shown by the absence of problems in 5/6 of our cases.…”

Section: Discussionmentioning

confidence: 99%

Complications of the naevoid basal cell carcinoma syndrome: results of a population based study.

Evans

Ladusans

Rimmer

et al. 1993

Journal of Medical Genetics

504

448

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There are many potential complications which have been reported in association with the naevoid basal cell carcinoma syndrome. We have been able to show the relative frequencies of these problems in a population based study of 84 cases in the north west of England. The major complications of basal cell carcinomas and jaw cysts occur in over 90% of patients by 40 years of age, but may both occur before 10 years of age. Less well described complications are ovarian calcification or fibroma (24%), medulloblastoma (5%), cardiac fibroma (3%), cleft palate (5%), and ophthalmic abnormalities such as squint or cataract (26%). This study more clearly defines the possible complications of the syndrome and gives clearer guidelines for counselling and screening affected and at risk persons.

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“…If they occur when tooth root formation is progressing, the pressure engendered can cause bending and breakage of the roots and marked displacement of adjacent teeth (Gorlin & Sedano, 1971). They recur frequently after removal (McClatchey et al, 1975) due either to incomplete removal or the presence of numerous daughter cysts in the walls (Thomas, 1959;Howell et al, 1964). Several patients have been described who had a change outside the cyst wall very like that ofa basal cell carcinoma, the so-called 'ameloblastoma' (Davidson, 1962;Clendenning ^r a/., 1964).…”

mentioning

confidence: 99%