“…This is in agreement with a previous report that VEGF plays an essential role in the regulation of mineralisation by stimulating differentiation of MSCs [31]. VEGF has also been confirmed to promote odontogenic differentiation of hDPSCs in vitro [32,33].…”
These findings implicate that ZnBG would be beneficial in regenerative endodontics and could influence the way present Zn containing clinical products are used.
“…This is in agreement with a previous report that VEGF plays an essential role in the regulation of mineralisation by stimulating differentiation of MSCs [31]. VEGF has also been confirmed to promote odontogenic differentiation of hDPSCs in vitro [32,33].…”
These findings implicate that ZnBG would be beneficial in regenerative endodontics and could influence the way present Zn containing clinical products are used.
“…However, hypoxia-inducing factor-1a (HIF-1a) and VEGF expression in DPSC and HDPF are then enhanced, and therefore, angiogenesis takes place. This explains why vascular neoformation plays a fundamental role in repairing the pulp tissue as these new vessels will be in control of fulfilling the metabolic and oxygenation needs of the pulp by the mediation of the pulp tissue nervous system through neuropeptides such as SP (Derringer et al 1996, Derringer & Linden 1998, Aranha et al 2010, Kim et al 2014, Zhang et al 2014.…”
Caviedes-Bucheli J, Gomez-Sosa JF, Azuero-Holguin MM, Ormeño-Gomez M, Pinto-Pascual V, Munoz HR.Angiogenic mechanisms of human dental pulp and their relationship with substance P expression in response to occlusal trauma.
“…Furthermore, lentivirus‐mediated human VEGF gene transfection (Zhang et al . ) and VEGF‐A165 peptide (D'Alimonte et al . ) promoted the odontogenic differentiation of human dental pulp stem cells (DPSCs) in vitro .…”
Recombinant human vascular endothelial growth factor promoted cell growth, odontogenic potential and in vitro angiogenesis via modulation of LOX expression. These results support the concept that rhVEGF may offer therapeutic benefits in regenerative endodontics.
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