Odontogenic cysts: classification, histological features and a practical approach to common diagnostic problems

Brown, Stephen; Conn, Brendan

doi:10.1016/j.mpdhp.2022.02.007

Cited by 2 publications

(19 citation statements)

References 26 publications

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“…[ 5 ] Reduced enamel epithelium is the covering epithelium of the developing tooth crown, the epithelial cell rest of Serres is remaining degenerated dental lamina which initiated tooth formation at the sixth week of embryonic development, while the epithelial cell rest of Malassez is remnants of Hertwig’s epithelial root sheath disintegration which plays a role in dental root formation. [ 2 6 ] All of these remnants will be trapped in the gingiva and embedded in bone. [ 6 ] The epithelium trapped in gingiva and bone can develop into odontogenic cysts and may undergo neoplastic transformation.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] Odontogenic cysts are pathological cavities lined with epithelium and filled with fluid, semisolid, or gaseous material, which develop from the remnants of odontogenic apparatus, while odontogenic tumours are solid tissue masses, which are not necessarily neoplastic. [ 2 3 ] A considerable amount of odontogenic lesions have been reported in the literature globally. [ 3 ] Among all cysts, odontogenic cysts had a prevalence of 15.31%, with radicular cysts being the most frequently found odontogenic cysts (48.67%), then dentigerous cysts, odontogenic keratocysts, and calcifying odontogenic cysts.…”

Section: Introductionmentioning

confidence: 99%

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Transformation of Odontogenic Cysts to Neoplasms - A Systematic Review

Sulistyani,

Iskandar,

Zairinal

et al. 2023

Annals of Maxillofacial Surgery

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Background: Odontogenic cysts have the potential to transform into neoplasms. However, the characteristics of those which transformed to neoplastic tissues have not been well described and the exact causes of that phenomenon are not yet clear. Objectives: This study aims to describe characteristics of odontogenic cysts that transformed into neoplasms and to look for their potential etiologies. Data Sources: English-written studies indexed in PubMed, Science Direct, and Proquest were assessed using keywords verified by Medical Subject Headings: ‘Odontogenic Cyst’ and ‘Neoplastic Cell Transformation’. Study Eligibility Criteria: Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines were used as guidance. Participants: Following steps in PRISMA guidelines, 19 articles were fully reviewed (three case series and 16 case reports) with 27 subjects of 16 males (59%) and 11 females (41%) from 15 to 86 years old. Results: Cystic origins were eight dentigerous cysts, four odontogenic keratocysts, two residual cysts, one radicular cyst, one calcifying odontogenic cyst, one follicular cyst, one glandular odontogenic cyst, and nine unspecified odontogenic cysts that transformed to ameloblastoma (3 cases) and carcinoma (24 cases). Limitations: Neoplastic transformations of odontogenic cysts arose from epithelial remnants of inadequate odontogenic cyst removal and chronic inflammation due to infection. However, the exact causes of their transformations remain unclear. Conclusions: Therefore, careful removal of odontogenic cysts and regular postoperative follow-ups are key to prevent recurrence and neoplastic transformation. Future studies are needed to investigate potential causes of neoplastic transformation of odontogenic cysts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transformation of Odontogenic Cysts to Neoplasms - A Systematic Review

Sulistyani,

Iskandar,

Zairinal

et al. 2023

Annals of Maxillofacial Surgery

View full text Add to dashboard Cite

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“…Numerous cysts, whether odonto-genic or non-odontogenic, can originate from epithelial remnants within the jaw bones. The diverse histological appearances of these lesions are attributed to their pluripotentiality and complex histogenesis [5]. Historically, these cysts were categorized into three types: odontogenic cysts of inflammatory origin, odontogenic developmental cysts, and non-odontogenic cysts.…”

Section: Introductionmentioning

confidence: 99%

“…This strategic realignment reflects the new Blue Book structure, designed to prioritize more aggressive lesions towards the end of each section. Moreover, the Blue Book now supplements each entity with "essential and desirable diagnostic criteria," emphasizing critical clinical or pathological features crucial for accurate diagnosis [1,5].…”

Section: Introductionmentioning

confidence: 99%

“…In a noteworthy addition, the non-odontogenic "surgical ciliated cyst" has been integrated into the category of jaw cysts, despite its well-established recognition. This incorporation signifies a fresh inclusion within this classification, enhancing its comprehensiveness and clinical relevance [1,5]. Furthermore, the sole newcomer to this classification is the "adenoid ameloblastoma," characterized by distinct ameloblastomatous differentiation and the presence of duct-like structures.…”

Section: Introductionmentioning

confidence: 99%

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Cysts of the jaws and how to make their diagnoses under a microscope: a need for a better communication between clinicians and pathologists

Strokov,

Cardot-Leccia,

Raybaud

et al. 2024

J Oral Med Oral Surg

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Introduction: Cysts of the jaws constitute an heterogenous group of lesions occurring in the maxillofacial region. Their diagnosis is challenging and necessitating a meticulous correlation of clinical, radiological, and pathological features. Pathologists often face numerous difficulties stemming from inadequate clinical and radiological information, along with limited samples. Nevertheless, clinicians are not always aware of the pathologist's concerns, making difficult to know exactly which pertinent clinical information they should deliver in their request form. The objective of this article is to illustrate the microscopic diagnostic pitfalls associated with cystic lesions of the jaws and enhance communication between oral surgeons and oral pathologist. Corpus: This section starts by examining the essential clinical and radiological data necessary for a precise pathological diagnosis. Subsequently, we discuss about the differential diagnosis of jaw cystic lesions, categorizing them into five distinct subsets based on their microscopic features, particularly their histological lining. For each subset, we engage in a detailed discussion concerning the primary diagnostic challenges and their implications for treatment decisions. Conclusion: Pathologist and clinicians are not irreconcilables: improved communication, rooted in a mutual understanding of each other's concerns, leads to optimizing the diagnosis and subsequently the treatment of jaw cysts.

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Odontogenic cysts: classification, histological features and a practical approach to common diagnostic problems

Cited by 2 publications

References 26 publications

Transformation of Odontogenic Cysts to Neoplasms - A Systematic Review

Transformation of Odontogenic Cysts to Neoplasms - A Systematic Review

Cysts of the jaws and how to make their diagnoses under a microscope: a need for a better communication between clinicians and pathologists

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