Odontogenic Carcinosarcoma: Clinicopathologic and Molecular Features of Three Cases, a Literature Review and Nomenclature Proposal

Cole, Grayson; Chi, Angela; Cook, Daniel R.; Kubik, Mark; Bilodeau, Elizabeth A.; Seethala, Raja R.

doi:10.1007/s12105-023-01569-3

Cited by 1 publication

(2 citation statements)

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“…4,6 The mechanism of transformation into a malignant tumor is also unclear, but it is believed that most cases are related to multiple recurrences and the absence of adjuvant therapy after surgery. 19 the tumor presents detailed histopathological descriptions; in general, the tumors showed various combinations of ameloblastic, clear cell and acanthomatous/squamous epithelial components, and fusiform components that ranged from myxoid to strongly sclerotic. In this study, we also found that the lesion is a biphasic malignant neoplasm, with the epithelial part and mesenchyme presenting mitoses and cell polymorphism.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological characteristics of odontogenic carcinosarcoma: A systematic review

da Silveira,

de Almeida Souto Montenegro,

de Albuquerque

et al. 2024

J Oral Pathology Medicine

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BackgroundThe aim of the present systematic review was to summarize evidence on odontogenic carcinosarcoma, analyzing clinical, epidemiological, imaging, histopathological, immunohistochemical, therapeutic, and prognostic features of this tumor.Materials and MethodsThis systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Searches were performed in the Ovid MEDLINE (Wolters Kluwer), PubMed (National Library of Medicine), Web of Science (Thomson Reuters), Scopus (Elsevier), and LILACS (Latin American and Caribbean Center on Health Sciences Information) databases, without publication date or language restrictions. Case reports or case series of OCS reporting clinical, radiological, and histopathological data that confirmed the diagnosis were selected. The Joanna Briggs Institute—University of Adelaide tool was used for critical appraisal of the included articles.ResultsOdontogenic carcinosarcoma is a rare, aggressive tumor associated with high mortality; however, the metastasis rate is low. The tumor has a male predilection. The mean patient age is 40 years, but there is no predilection for age. The left posterior mandible is the most affected site, but no specific radiographic features have been reported.ConclusionGiven its rarity, dentists, oral‐maxillofacial surgeons, and physicians need to be aware of odontogenic carcinosarcoma in order to increase the diagnostic potential, preventing delays in diagnosis and treatment and thus contributing to lower morbidity of the tumor.

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Section: Discussionmentioning

confidence: 99%

“…Seventeen articles reporting cases of OCS were selected. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] The PRISMA diagram shows the complete article selection process (Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%