Odontoblast control of dental pulp inflammation triggered by cariogenic bacteria

Interactive effects of LPS and dentine matrix proteins on human dental pulp stem cells

“…Amongst the four tested cytokines (IL-6, IL-10, IL-1b and CXCL2), which are all associated with inflamed pulp tissue (Farges et al 2013), only IL-6 was detected in the supernatant of human DPSCs. IL-6 is a multifunctional, proinflammatory cytokine that plays an important role during pulp inflammation, for example, as a regulator of the acute phase reaction and of lymphocyte differentiation (Barkhordar et al 1999).…”

Minimally invasive endodontics: a new diagnostic system for assessing pulpitis and subsequent treatment needs

“…Recent research shows that the pulp is more resilient to significant microbial attacks than previously thought (Farges et al . , Bjørndal et al . , Cooper et al .…”

“…Therefore, dentine and pulp must be considered together as a pulpo-dentinal complex (Pashley 1996). Recent research shows that the pulp is more resilient to significant microbial attacks than previously thought (Farges et al 2013, Bjørndal et al 2014, Cooper et al 2014. Pulpal defence mechanisms to reduce the diffusion of microbes and microbial products towards the pulp include sclerosis of dentinal tubules and the formation of tertiary dentine (Bjørndal 2008).…”

Class II Antigen-presenting Dendritic Cells and Macrophages in Healthy and Carious Human Teeth

“…These differences in the environment might affect the distribution of class II expressing cells in dental pulp. 17,18 The purpose of this study was to elucidate the distribution of class II expressing cells in developing, healthy and carious human teeth, to clarify when human pulp acquires an immunologic defense potential and how this reacts to dental caries.…”