Ocuserts: A Novel Formulation Approach in Drug Delivery System

Parveen, Nida; Joshi, Himanshu

doi:10.36348/sjmps.2020.v06i05.005

Cited by 4 publications

(1 citation statement)

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“…Ocuserts were crafted using a cork borer. The ocuserts were kept in an airtight container at room temperature (Parveen & Joshi, 2020).…”

Section: Preparation Of Ciprofloxacin Hcl Nanoparticlesmentioning

confidence: 99%

Formulation and Evaluation of Ocusert Embeded with Ciprofloxacin Loaded Nanoparticles

Shaikh,

Khan,

Shaikh

et al. 2024

IJALSR

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Ophthalmic drug delivery is very challenging. Upon the application of conventional topical ophthalmic formulations, a significant portion of the administered dose goes to waste due to the existence of various ophthalmic barriers. There is a swift elimination of the applied solution from the anterior part of the eyes through the nasolacrimal duct to the nasal cavity. The aim of this study was to develop an ocusert embedded with ciprofloxacin-loaded nanoparticles to increase patient compliance by improving local delivery of the drug. Ciprofloxacin-loaded Eudragit RL PO polymeric nanoparticles were prepared and evaluated for particle properties. These drug-loaded polymeric nanoparticles were embedded in an ocusert made of carboxymethylcellulose. Various properties of ocuserts, like film endurance, surface pH, disintegration time, and sterility, were studied. A drug-loaded nanoparticle-embedded ocusert was found to be a suitable system to improve ophthalmic drug delivery. The nanoparticles' particle size, polydispersity index (PDI), entrapment efficiency, and in vitro drug release were all assessed. The generated ocuserts underwent screening for sterility, drug content, weight variability, folding durability, thickness, surface pH, and disintegration time. In order to gain insight into the process by which drugs release from the formulations, the in vitro drug release from the preparations was examined using a standard Abron Visking semipermeable membrane.

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“…Ocuserts were crafted using a cork borer. The ocuserts were kept in an airtight container at room temperature (Parveen & Joshi, 2020).…”

Section: Preparation Of Ciprofloxacin Hcl Nanoparticlesmentioning

confidence: 99%