Oculomotor, Postural, and Perceptual Asymmetries Associated with a Common Cause: Craniofacial Asymmetries and Asymmetries in Vestibular Organ Anatomy

Rousie, D.; Hache, J.-C.; Pellerin, P.; Deroubaix, J.P.; Tichelen, P. Van; Berthoz, Alain

doi:10.1111/j.1749-6632.1999.tb09213.x

Cited by 20 publications

(14 citation statements)

References 10 publications

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“…This concurs with the observation that the phenotype of body distortion and skeletal deformations in human AIS are also rather variable (Weinstein et al, 2008). Assuming a general validity of the results in Xenopus, the gaze/ posture deficits that accompany human AIS (Jensen and Wilson, 1979;Byl et al, 1997;Wiener-Vacher and Mazda, 1998;Rousie et al, 1999;Manzoni and Miele, 2002;Mirovsky et al, 2006;Mallau et al, 2007) are compatible with a common vestibular origin, although a secondary influence of the distorted skeletal geome- -66). A, B, 3D reconstructed micro-CT scans of the vertebral column in a young adult control frog (A) and a frog that receivedaULatpre-metamorphicstage56(B).C, Opticalextractionof3vertebrae(v2,v5,v8)and3DgridofthedeformationinayoungadultULfrog.D,Planeandaxisofrotationofv2,v5,andv8inthecoronal plane;␣indicatestherotationoftheactualfrontalplane(red)ofthevertebrarelativetothetheoreticalcoronalplane(green);␤indicatestherotationofthevertebralaxis(green)relativetothedorsoventralaxis (blue).…”

Section: Discussionsupporting

confidence: 74%

“…An impaired postural and locomotor performance Mallau et al, 2007), as well as deficits in extraocular motor control and gaze stabilization (Wiener-Vacher and Mazda, 1998;Rousie et al, 1999), including spontaneous and positional nystagmus (Jensen and Wilson, 1979;, was encountered in many patients. Most of these symptoms are compatible with a bilateral imbalance of the activity in central vestibular neurons (WienerVacher and Mazda, 1998;Manzoni and Miele, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…A vestibular dysfunction has often been proposed as the trigger for AIS, but no causality has been shown so far (Herman et al, 1985;Rousie et al, 1999). An impaired postural and locomotor performance Mallau et al, 2007), as well as deficits in extraocular motor control and gaze stabilization (Wiener-Vacher and Mazda, 1998;Rousie et al, 1999), including spontaneous and positional nystagmus (Jensen and Wilson, 1979;, was encountered in many patients.…”

Section: Introductionmentioning

confidence: 99%

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Vestibular Asymmetry as the Cause of Idiopathic Scoliosis: A Possible Answer fromXenopus

Lambert¹,

Malinvaud²,

Glaunès

et al. 2009

J. Neurosci.

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Human idiopathic scoliosis is characterized by severe deformations of the spine and skeleton. The occurrence of vestibular-related deficits in these patients is well established but it is unclear whether a vestibular pathology is the common cause for the scoliotic syndrome and the gaze/posture deficits or if the latter behavioral deficits are a consequence of the scoliotic deformations. A possible vestibular origin was tested in the frog Xenopus laevis by unilateral removal of the labyrinthine endorgans at larval stages. After metamorphosis into young adult frogs, X-ray images and three-dimensional reconstructed micro-computer tomographic scans of the skeleton showed deformations similar to those of scoliotic patients. The skeletal distortions consisted of a curvature of the spine in the frontal and sagittal plane, a transverse rotation along the body axis and substantial deformations of all vertebrae. In terrestrial vertebrates, the initial postural syndrome after unilateral labyrinthectomy recovers over time and requires body weight-supporting limb proprioceptive information. In an aquatic environment, however, this information is absent. Hence, the lesion-induced asymmetric activity in descending spinal pathways and the resulting asymmetric muscular tonus persists. As a consequence the mostly cartilaginous skeleton of the frog tadpoles progressively deforms. Lack of limb proprioceptive signals in an aquatic environment is thus the element, which links the Xenopus model with human scoliosis because a comparable situation occurs during gestation in utero. A permanently imbalanced activity in descending locomotor/posture control pathways might be the common origin for the observed structural and behavioral deficits in humans as in the different animal models of scoliosis.

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vestibular Asymmetry as the Cause of Idiopathic Scoliosis: A Possible Answer fromXenopus

Lambert¹,

Malinvaud²,

Glaunès

et al. 2009

J. Neurosci.

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“…As its name suggests, the aetiology of IS is largely unknown although genetic factors [2] are known to play a role (see [3] for a review). Beside scoliosis, neurological dysfunctions have often been observed in IS patients, including vestibular [4,5], postural [5,6] and locomotor [7] deficits. These symptoms suggest that a defect of processing by the central nervous system may contribute in the aetiopathogenesis of IS.…”

Section: Introductionmentioning

confidence: 99%

A new approach to corpus callosum anomalies in idiopathic scoliosis using diffusion tensor magnetic resonance imaging

et al. 2014

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Purpose Idiopathic scoliosis (IS) is a frequent 3D structural deformity of the spine with a multi-factorial aetiology which remains largely unclear. In the last decade, human magnetic resonance imaging (MRI) morphometry studies (e.g. cortical thickness, 2D shape of the corpus callosum) have aimed to investigate the potential contribution of the central nervous system in the etiopathogenesis of IS. Recent developments in diffusion tensor imaging (DTI) allow us to extend the previous work to the study of white matter microstructure. Here, we hypothesized that part of the corpus callosum could show a difference in white matter microstructure in IS patients as compared to healthy controls.Methods We acquired DTI in 10 girls with IS and in 49 gender-matched controls to quantify the fractional anisotropy (FA) along the corpus callosum. Results Despite a very similar pattern of FA along the corpus callosum (maxima in the splenium and the genu and minimum in the isthmus), we found a significantly lower FA in the body in patients with IS as compared to control subjects. This region is known to connect the motor and premotor cortices of the two hemispheres. Conclusion This first diffusion magnetic resonance imaging brain study in IS patients, suggests that differences in white matter development, such as synchronization of axonal myelination and pruning could be involved in the etiopathogenesis of IS.

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“…In addition, structural abnormality with communication between the lymphatic posterior and lateral semicircular canals with a frequency of 55% in 95 AIS patients was described, whereas it was only 15% in 445 participants who underwent MRI and computed tomography (Rousie et al, 1999). This abnormality is associated with the following signs: the absence of rotatory vertigo but frequent instability, transport sickness on head tilt to the side of the anomaly, spatial disorientation in new environments, and nystagmus.…”

Section: Mri Of the Vestibular Apparatusmentioning

confidence: 99%

Sensorimotor Integration in Adolescent Idiopathic Scoliosis Patients

Pialasse¹,

Descarreaux²,

Mercier³

et al. 2012

Recent Advances in Scoliosis

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Oculomotor, Postural, and Perceptual Asymmetries Associated with a Common Cause: Craniofacial Asymmetries and Asymmetries in Vestibular Organ Anatomy

Cited by 20 publications

References 10 publications

Vestibular Asymmetry as the Cause of Idiopathic Scoliosis: A Possible Answer fromXenopus

Vestibular Asymmetry as the Cause of Idiopathic Scoliosis: A Possible Answer fromXenopus

A new approach to corpus callosum anomalies in idiopathic scoliosis using diffusion tensor magnetic resonance imaging

Sensorimotor Integration in Adolescent Idiopathic Scoliosis Patients

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