Oculomotor and Sensory Mesencephalic Trigeminal Neurons in Lungfishes: Phylogenetic Implications

Bartheld, Christopher S. von

doi:10.1159/000114122

Cited by 22 publications

(20 citation statements)

References 17 publications

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“…In contrast, the situation found in Protopterus , with labeled fibers among the deep cellular tectal layer, resembles the condition found in anurans and reptiles . In both lungfishes studied, the large neurons of the mesencephalic trigeminal nucleus are easily recognized in the dorsal part of the tectum [von Bartheld, 1992] and do not show any particular relation to the orexin-ir fibers. Only in the rat is conspicuous innervation of the mesencephalic trigeminal nucleus described [Stoyanova and Lazarov, 2005].…”

Section: Distribution Of Orexin-ir Fibers In the Brain Of Vertebratesmentioning

confidence: 89%

Distribution of Orexin/Hypocretin Immunoreactivity in the Brain of the Lungfishes Protopterus dolloi and Neoceratodus forsteri

et al. 2009

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Lungfishes are currently considered the closest living relatives of tetrapods and represent an interesting group for the study of evolutionary traits in the transition from fishes to tetrapods. The brains of lungfishes have received little attention in comparative studies probably due to the difficulty of obtaining these unique animals. In the present study the distribution of orexin (hypocretin)-like immunoreactivity was studied in the brain of the African lungfish Protopterus dolloi and the Australian lungfish Neoceratodus forsteri by using antibodies directed against the mammalian orexin-A and orexin-B peptides. Simultaneous detection of orexins and tyrosine hydroxylase or serotonin was used to assess the precise location of the orexins in the brain and to evaluate the possible influence of the orexin system on the monoaminergic cell groups. Although some differences were noted, a common pattern for the distribution of orexins in the two lungfishes studied was observed. In both species, most immunoreactive neurons were observed in the suprachiasmatic nucleus and dorsal hypothalamus. Only in Neoceratodus, however, were important cell populations found in the preoptic area and infundibular hypothalamus, whereas small numbers of faintly reactive neurons were present in the lateral septum and ventral striatum. Fiber labeling was widely distributed in all main brain subdivisions, but was more abundant in regions such as the septum, preoptic area, suprachiasmatic nucleus, lateral hypothalamic area, thalamus, pretectum and tegmentum. Less conspicuous was the innervation of the pallial regions, habenula, optic tectum, rhombencephalic reticular formation and spinal cord. Orexinergic innervation was found in close contact with dopaminergic, noradrenergic and serotoninergic cell groups, homologous to the substantia nigra in the midbrain tegmentum, the locus coeruleus, the nucleus of the solitary tract and the raphe nuclei. Although unique features have been found for lungfishes, the location of orexin immunoreactive elements is largely consistent with that recently reported following a similar approach in amphibians and amniotes, suggesting that the general organization of this peptidergic system occurred in the common ancestor of lungfishes and tetrapods.

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Section: Distribution Of Orexin-ir Fibers In the Brain Of Vertebratesmentioning

confidence: 89%

Distribution of Orexin/Hypocretin Immunoreactivity in the Brain of the Lungfishes Protopterus dolloi and Neoceratodus forsteri

et al. 2009

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“…All forms have a recognizable principal and accessory abducens, except some mammals that have secondarily lost the accessory abducens. [Compiled after Ariens-Kappers et al, 1936;Kishida et al, 1986;von Bartheld, 1992;Baker, 1993, 1995;Fritzsch et al, 1990;Fritzsch and Northcutt, 1993;Song and Boord, 1993;Szekely and Matesz, 1993;Wake, 1993;Fritzsch, 1998a, b].…”

Section: Discussionmentioning

confidence: 99%

Of Mice and Genes: Evolution of Vertebrate Brain Development

Fritzsch

1998

Brain Behav Evol

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In this review the current understanding of genetic and molecular evolution of development, in particular the formation of the major axis of bilateral animals, is critically evaluated, and the early pattern formation in the hindbrain is related as much as possible to these processes. On the genetic level it is proposed that the exuberant multiplication of regulatory genes compared to that of structural genes relates to the increased flexibility of early vertebrate development. In comparisons to fruit flies, many conserved genes are found to be expressed very differently, while many others seem to reflect a comparable pattern and thus suggest a conservation of function. Even genes with a largely conserved pattern of expression may change the level at which they are expressed and the mechanisms by which they are regulated in their expression. Evolution and development of hindbrain motoneurons is reviewed, and it is concluded that both comparative data as well as more recent experimental data suggest a limited importance for the rhombomeres. Clearly, many cell fate-specifying processes work below the level of rhombomeres or in the absence of rhombomeres. It is suggested that more comparative developmental data are needed to establish firmly the relationship between homeobox genes and rhombomere specification in vertebrates other than a few model species.

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“…The laterality of the trochlear motoneurons appears to be variable among vertebrates. In lamprey (Finger and Rovainen, 1979;Fritzsch et al, 1990), carp (Luiten and Dijkstra-de Vlieger, 1978), goldfish (Graf and McGurk, 1985), lungfish (von Bartheld, 1992), some amphibians (Fritzsch and Sonntag, 1987), and mammals (Gacek, 1974;Labandeira Garcia et al, 1983;Miyazaki, 1985;Murphy et al, 1986), the trochlear nucleus is composed of both ipsiand contralaterally projecting neurons. However, in salamanders (Naujoks-Manteuffel et al, 1986), stargazers (Leonard and Willis, 1979), the weakly electric fish Gnathonemus petersii (Szabo et al, 1987), and cartilaginous fish, the trochlear motoneurons are reported to innervate only the contralateral superior oblique muscle.…”

Section: Distribution Of Oculomotor and Trochlear Motoneuronsmentioning

confidence: 99%

“…The innervation pattern of these muscles has been studied by using modern neuroanatomical methods in representatives of the major jawedvertebrate lineages (Matesz and Székely, 1977;Luiten and Dijkstra-de Vlieger, 1978;Rosiles and Leonard, 1980;Heaton and Wayne, 1983;Labandeira et al, 1983;Porter et al, 1983;Graf and Brunken, 1984;Graf and McGurk, 1985;Graf and Baker, 1985;Naujoks-Manteuffel et al, 1986;Evinger et al, 1987;Szabo et al, 1987;BarbasHenry and Lohman, 1988;von Bartheld, 1992). These studies have shown that the six eye muscles are innervated by motoneurons distributed in three motonuclei: The oculomotor nucleus innervates the superior, inferior, and medial recti, as well as the inferior oblique.…”

mentioning

confidence: 99%

“…The trochlear nucleus innervates the superior oblique and the abducens nucleus innervates the lateral rectus. Furthermore, these studies have demonstrated that in most jawed-vertebrates, with the exception of elasmobranch fishes (sharks, skates, and rays; Rosiles and Leonard, 1980;Graf and Brunken, 1984) and possibly lungfishes (von Bartheld, 1992), two motoneuron pools, that of the superior rectus and superior oblique, are contralateral to the muscles they innervate. The other motoneuron pools are ipsilateral to their respective muscles.…”

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confidence: 99%

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Innervation of the medial rectus muscle in the ratfish,Hydrolagus colliei

Puzdrowski

1998

J. Comp. Neurol.

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Oculomotor organization in elasmobranch fish (sharks, skates, and rays) differs from that in other vertebrates in that the medial rectus muscle is innervated by contralateral rather than ipsilateral motoneurons. Distinguishing whether this innervation pattern is unique to the elasmobranchs, or is the ancestral pattern for cartilaginous fishes, requires examination of a representative of the sister group to the elasmobranchs, the holocephalans (ratfish). In the present study, the innervation pattern of the medial rectus was examined in a ratfish, Hydrolagus colliei, by using biotinylated dextran amines (BDA, 3,000 MW). Labeled cells were revealed in the contralateral oculomotor nucleus. Therefore, an innervation pattern in which the medial rectus muscle is innervated by contralateral motoneurons is the primitive condition for cartilaginous fishes.

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Oculomotor and Sensory Mesencephalic Trigeminal Neurons in Lungfishes: Phylogenetic Implications

Cited by 22 publications

References 17 publications

Distribution of Orexin/Hypocretin Immunoreactivity in the Brain of the Lungfishes <i>Protopterus dolloi</i> and <i>Neoceratodus forsteri</i>

Distribution of Orexin/Hypocretin Immunoreactivity in the Brain of the Lungfishes <i>Protopterus dolloi</i> and <i>Neoceratodus forsteri</i>

Of Mice and Genes: Evolution of Vertebrate Brain Development

Innervation of the medial rectus muscle in the ratfish,Hydrolagus colliei

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