Oculoand Retinotoxicity of Antitumor Drugs Based on Alkylating Agents

Abstract

The positive result of chemotherapy for cancer is an increase of the duration of remission and the life of treated patients. However against this background negative secondary effects of chemotherapy began to appear as well. These effects reduce the quality of life of treated patients. These include ophthalmic complications. The review provides clinical data on ophthalmic toxicity of 7 representatives of alkylating compounds and interferon used in chemotherapy. Much attention in the review is paid to retinotoxic effects of these drugs. The mechanism of their geno- and cytotoxic effects and also the role of participants of excision repair in this - N-alkyl-adenine-DNA-glycosylase and poly(ADP-ribose)-polymerase (PARP1) - are considered.