Ocular Vestibular Evoked Myogenic Potentials: Frequency Tuning to Air-Conducted Acoustic Stimuli in Healthy Subjects and Ménière’s Disease

Winters, Stephanie M.; Berg, Ingvar T.B.; Grolman, Wilko; Klis, Sjaak F.L.

doi:10.1159/000324858

Cited by 54 publications

(42 citation statements)

References 52 publications

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“…Rauch et al [2004] were the first to demonstrate that VEMP tuning could be altered by pathology that affects the mechanics of the inner ear. Instead of demonstrating optimal responses at 500 Hz, as is the trend for most control subjects, patients with Ménière's disease exhibited higher amplitudes and lower thresholds at a frequency of 1 kHz Lin et al, 2006;Murofushi et al, 2009;Kim-Lee et al, 2009;Winters et al, 2011]. This upward shift in resonance was attributed to the presence of endolymphatic hydrops in the otolith organs, causing an increase in stiffness .…”

Section: Introductionmentioning

confidence: 89%

Tuning Characteristics of Ocular and Cervical Vestibular Evoked Myogenic Potentials in Intact and Dehiscent Ears

Taylor¹,

Bradshaw²,

Halmagyi³

et al. 2012

Audiol Neurotol

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Cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs) to air-conducted tone bursts (250–2000 Hz) were recorded in 14 patients with superior canal dehiscence (SCD) and 32 healthy controls. For cVEMPs, the most common ‘optimal frequency’ in control ears (48.2%) was 500 Hz; for oVEMPs, it was 1000 Hz (51.8%). We found a significant interaction between age and frequency, with a shift towards higher-frequency tuning in older subjects. cVEMP and oVEMP tuning in SCD was characterised by a broadening of amplitude and threshold tuning curves. The tendency of cVEMPs to tune to lower frequencies compared to oVEMP was enhanced in SCD. Differences in cVEMP and oVEMP ‘optimal frequencies’, demonstrated in 57.1% intact ears and 81.3% dehiscent ears, imply differences in the recruitment of hair cells generating these two reflexes. Age-matched oVEMP amplitudes provided excellent separation between SCD and control ears. Although cVEMP amplitudes overlapped between SCD and control ears, better separation was achieved by using a 2-kHz stimulus.

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Section: Introductionmentioning

confidence: 89%

Tuning Characteristics of Ocular and Cervical Vestibular Evoked Myogenic Potentials in Intact and Dehiscent Ears

Taylor¹,

Bradshaw²,

Halmagyi³

et al. 2012

Audiol Neurotol

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“…Also, VEMP thresholds at multiple frequencies yield, at least in Menière's disease patients, a more sensitive measure with less intersubject variability (in normals), further increasing the clinical utility of the cVEMP [van Tilburg et al, submitted paper]. Threshold measurements in oVEMPs have also been shown to differ between healthy and pathological subjects [161]. Furthermore, using only a present/absent criterion, the degree of damage to the otoliths is not measurable.…”

Section: Challenges In Establishing a Diagnosis Of Bvhmentioning

confidence: 99%

Bilateral Vestibular Hypofunction: Challenges in Establishing the Diagnosis in Adults

Berg

Tilburg

Kingma

2015

ORL

106

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Bilateral vestibular hypofunction (BVH) probably represents a heterogeneous disorder with different types of clinical pictures, with and without vertigo. In spite of increasingly sophisticated electrophysiological testing, still many challenges are met when establishing a diagnosis of BVH. Here, we review the main challenges, which are a reflection of its often difficult clinical presentation and the lack of diagnostic standards regarding the implementation and interpretation of vestibular tests. These challenges show that there is an urgent need for standardization. The resulting decisions should be used for the development of uniform diagnostic criteria for BVH, which are, at present, not yet available.

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“…Patients with MD have been shown to have lower VEMP than normal controls [Winters et al, 2012], though it has also been demonstrated that VEMP can be normal or even augmented, particularly in the earlier stages of the disease [Wen et al, 2012;Young et al, 2003]. Although several studies showed subjects with MD to have significant abnormalities in cVEMP and oVEMP, there is wide variation in the results [Taylor et al, 2011].…”

mentioning

confidence: 99%

Diagnostic Value of Frequency-Associated Vestibular-Evoked Myogenic Potential Responses in Ménière's Disease

Şalvız

Yüce²,

Karataş³

et al. 2015

Audiol Neurotol

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Thirty subjects with unilateral Ménière's disease (MD) and 18 age-matched controls underwent cervical (cVEMP) and ocular vestibular-evoked myogenic potential (oVEMP) testing using bilateral air-conducted stimulation (ACS) with stimulus frequencies of 500 and 1,000 Hz. The aim of this study is to determine the diagnostic value of frequency-associated responses in MD using oVEMP and cVEMP following 500- and 1,000-Hz ACS. In healthy controls and unaffected ears, responses to 500 Hz were found better than 1,000-Hz ACS in both oVEMP and cVEMP, while ears with MD responded to 1,000-Hz ACS better than to 500-Hz ACS in oVEMP. In cVEMP tests, affected ears responded to 500-Hz and 1,000-Hz ACS equally. Amplitude ratios of 1,000/500 Hz in both oVEMP and cVEMP were successful in differing affected ears from unaffected ears and healthy controls. This study showed frequency alteration of oVEMP and cVEMP can be used as a diagnostic test battery in MD.

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Ocular Vestibular Evoked Myogenic Potentials: Frequency Tuning to Air-Conducted Acoustic Stimuli in Healthy Subjects and Ménière’s Disease

Cited by 54 publications

References 52 publications

Tuning Characteristics of Ocular and Cervical Vestibular Evoked Myogenic Potentials in Intact and Dehiscent Ears

Tuning Characteristics of Ocular and Cervical Vestibular Evoked Myogenic Potentials in Intact and Dehiscent Ears

Bilateral Vestibular Hypofunction: Challenges in Establishing the Diagnosis in Adults

Diagnostic Value of Frequency-Associated Vestibular-Evoked Myogenic Potential Responses in Ménière's Disease

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