Ocular Toxoplasmosis in Tropical Areas: Analysis and Outcome of 190 Patients from a Multicenter Collaborative Study

Huang, Philemon; Chen, Jianping; Vasconcelos-Santos, Daniel Vítor; Arruda, Jacqueline Souza Dutra; Majumder, Parthopratim Dutta; Anthony, Eliza; Ganesh, Sudha K; Biswas, Jyotirmay; Ling, Ho Su; Teoh, Stephen C.; Agrawal, Rupesh

doi:10.1080/09273948.2017.1367407

Cited by 14 publications

(7 citation statements)

References 33 publications

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“…This is older than that in OT patients in European studies, ranging from 29.5 to 50.2 years. [ 9 , 10 ] In Korean patients, the percentage of bilateral cases (10.9%) was lower compared to that (32%) of a European study. [ 1 ]…”

Section: Discussionmentioning

confidence: 77%

Patterns of ocular toxoplasmosis presenting at a tertiary eye care center in Korean patients

et al. 2018

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The objective of this study was to describe demographic and clinical features of ocular toxoplasmosis (OT) in Korean patients compared to those in other countries.This retrospective study comprised 46 patients diagnosed with OT. All participants were recruited at the uveitis clinic in Seoul St. Mary's Hospital.The mean age of patients was 54 years. Of 46 patients, 31 (67.4%) were females. Of all patients, 24 (52.2%) had definite eating history of wild boar meat or deer blood while 5 (10.9%) had history of close contact with cats. The most common forms of OT were vitritis (91.3%) combined with retinochoroiditis (65.2%). Active retinochoroidal lesion was located at the peripheral retina in 18 (39.1%) patients, central retina in 8 (17.4%) patients, and peripapillary retina in 4 (8.7%) patients. Seven (15.2%) cases were clinically diagnosed with typical OT without serologic evidence. Thirty-nine (84.8%) had serum IgG for toxoplasmosis. However, only 8 (17.4%) had serum IgM. In 65.2% of patients, there was no complication after treatment. The most common ocular complication was macular scar (8.7%).The present study provides demographic and clinical characteristics of OT in Korea, a low endemic area of Toxoplasma gondii. Acquired infection is the major cause of OT in Korea. Even though Korea is a low endemic area of Toxoplasma gondii, OT is a preventable and common cause of acquired infectious uveitis.

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Section: Discussionmentioning

confidence: 77%

Patterns of ocular toxoplasmosis presenting at a tertiary eye care center in Korean patients

et al. 2018

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“…Huang et al reported in 2017 that final visual acuity of 20/40 or better was achieved in 74% of patient with ocular toxoplasmosis. 6 Tan et al reported that 76.9% of patients with ocular bartonellosis in Malaysia had a final visual outcome of 6/18 or better. 7 From our literature search, most reported cases were single infections either by T. gondii or B. hensalae.…”

Section: Discussionmentioning

confidence: 99%

Neuroretinitis secondary to dual infection of Toxoplasma gondii and Bartonella hensalae

Siti-Khadijah

Yaakub²,

Muhammed³

et al. 2019

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A 73-year-old lady with underlying diabetes presented with acute loss of central vision in the left eye. Examination revealed visual acuity of 6/60 in the left eye with positive relative afferent pupillary defect and optic disc swelling with macular oedema. Right eye visual acuity was 6/12 with unremarkable findings. Optical coherence tomography (OCT) showed elevated macular with ceacocentral field defect on Humphrey visual field. Connective tissue screening and tubercular screening were negative. Serological screening for Toxoplasma sp and Bartonella sp were positive. She was diagnosed as neuroretinitis secondary to both infections and started on oral azithromycin 500 mg once a day and oral corticosteroid. Her final vision improved to 6/12 with normal optic disc and resolved macular oedema.

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“…Author details 1 Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia. 2 NeURos Research Group, Escuela de Medicina Y Ciencias de La Salud, Universidad del Rosario, Carrera 24 # 63 C 69, Bogotá, Colombia. 3 Escuela Superior de Oftalmología-Instituto Barraquer de América, Bogotá, Colombia.…”

Section: Supplementary Informationunclassified

“…Ocular toxoplasmosis (OT) is a primary cause of posterior uveitis worldwide, particularly in South America [ 1 , 2 ]. OT results from an acquired or congenital infection by the obligate intracellular protozoan parasite Toxoplasma gondii (Tg), which can infect both humans and animals.…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of different antibiotic regimens in patients with ocular toxoplasmosis: systematic review and meta-analysis

et al. 2021

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Background Ocular toxoplasmosis (OT) is the most common cause of posterior uveitis, which leads to visual impairment in a large proportion of patients. Antibiotics and corticosteroids lower the risk of permanent visual loss by controlling infection and inflammation. However, there remains disagreement regarding optimal antibiotic therapy for OT. Therefore, this systematic review and meta-analysis were performed to determine the effects and safety of existing antibiotic treatment regimens for OT. Methods MEDLINE, EMBASE, The Cochrane Central Register of Controlled Trials, LILACS, WHO International Clinical Trials Registry Platform portal, ClinicalTrials.gov, and Gray Literature in Europe (“OpenGrey”) were searched for relevant studies; manual searches of reference lists were performed for studies identified by other methods. All published and unpublished randomized controlled trials that compared antibiotic schemes known to be effective in OT at any dosage, duration, and administration route were included. Studies comparing antibiotics with placebo were excluded. This review followed standard methodological procedures recommended by the Cochrane group. Results Ten studies were included in the narrative summary, of which four were included for quantitative synthesis (meta-analysis). Interventions were organized into three groups: intravitreal clindamycin versus pyrimethamine + sulfadiazine, trimethoprim + sulfamethoxazole versus other antibiotics, and other interventions. The first comparison favored intravitreal clindamycin (Mean difference (MD) = 0.10 logMAR; 95% confidence interval = 0.01 to 0.22). However, this finding lacks clinical relevance. Other outcomes showed no statistically significant differences between the treatment groups. In general, the risk of performance bias was high in evaluated studies, and the quality of the evidence found was low to very low. Conclusions No antibiotic scheme was superior to others, and the selection of a treatment regimen depends on multiple factors; therefore, treatment should be chosen based on safety, sulfa allergies, and availability.

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Ocular Toxoplasmosis in Tropical Areas: Analysis and Outcome of 190 Patients from a Multicenter Collaborative Study

Cited by 14 publications

References 33 publications

Patterns of ocular toxoplasmosis presenting at a tertiary eye care center in Korean patients

Patterns of ocular toxoplasmosis presenting at a tertiary eye care center in Korean patients

Neuroretinitis secondary to dual infection of Toxoplasma gondii and Bartonella hensalae

Safety and efficacy of different antibiotic regimens in patients with ocular toxoplasmosis: systematic review and meta-analysis

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