Ocular tolerance of a new multipurpose solution specifically formulated for daily wear of silicone hydrogel contact lenses

Martín, Raúl; Rodríguez, Guadalupe; Juan, Victoria de; Fernández, Itziar; Sánchez, Irene; Rosa, Cristina de la; Paz, Isabel de Almeida; Zalama, Maria

doi:10.1016/j.clae.2010.09.003

Cited by 4 publications

(13 citation statements)

References 22 publications

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“…Other studies have not found relevant differences in bulbar hyperemia after hours, weeks, and one month of scl use with different mps (16,17,24). In general, in the present study, the lowest frequency of hyperemia was observed between the new mps and balafilcon A, and the highest was observed between mps and lotrafilcon B.…”

Section: Discussionsupporting

confidence: 45%

“…19 (1): 1-14, enero-abril de 2021 depends on the concentration and composition of solutions (12). Among the different in vivo techniques, corneal staining is the most commonly used to determine the biocompatibility of mps with the ocular surface, in addition to the evaluation of comfort, tear film and hyperemia (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

“…Different solutions containing phmb or its derivatives have been reported to cause excessive corneal staining with PureVision (balafilcon A material) scl after two hours of lens insertion (3,17), and a lower staining grade with Airoptix (lotrafilcon B material) cl, which tends to decrease over time, and disappears completely following six days of daily use, together with hyperemia (3,16). Three-month assessments have also shown that balafilcon A significantly increased corneal staining with all types of mps (except those with hydrogen peroxide), and that the highest percentage of corneal staining occurred with solutions containing phmb.…”

Section: Introductionmentioning

confidence: 99%

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Biocompatibilidad con la superficie ocular y actividad antimicrobiana de una nueva solución multipropósito para lentes de contacto

Rodríguez¹,

Jiménez

Martín³

et al. 2021

Rev. Cienc. salud

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Introducción: las soluciones multipropósito (SMP) para lentes de contacto blandos (LCB) desempeñan un papel esencial en la inhibición de agentes patógenos. Su efectividad antimicrobiana se evalúa in vitro, y su seguridad, in vivo, con ensayos clínicos que incluyen una combinación de diferentes soluciones y materiales para lentes. El objetivo es evaluar la biocompatibilidad de una nueva SMP producida en Colombia que contiene polihexametileno biguanida (PHMB) y determinar su actividad antimicrobiana. Materiales y métodos: estudio cruzado con 25 sujetos no usuarios de lentes, que fueron adaptados con cinco combinaciones diferentes de materiales de LCB con una nueva solución salina fisiológica de control (CS). El grosor corneal, la hiperemia conjuntival, la tinción corneal y la comodidad se evaluaron después de dos horas de uso del LC. La efectividad antimicrobiana se midió utilizando ensayos estándar ISO 14729. Resultados: solo hubo una diferencia significativa entre la nueva SMP y el CS para el Comfilcon A (p < 0.05). Tampoco hubo diferencias significativas para el grosor o la tinción corneal, entre la combinación del material del lente y la nueva SMP con el CS (p > 0.05). Después de dos horas de uso del lente, las puntuaciones de confort fueron superiores a 7.8. La SMP redujo las unidades formadoras de colonias (UFC) de bacterias en más de 3 log, y las UFC fúngicas en más de 1.0 log. Conclusiones: la nueva SMP cumplió con los estándares antimicrobianos de ISO 14729, y se considera segura y biocompatible con la superficie ocular, con altos niveles de confort.

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Section: Discussionsupporting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biocompatibilidad con la superficie ocular y actividad antimicrobiana de una nueva solución multipropósito para lentes de contacto

Rodríguez¹,

Jiménez

Martín³

et al. 2021

Rev. Cienc. salud

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“…Despite some disputes existing in the literature, several studies have shown similarity in the performance of different MPDS despite pointing to different trends. For instance, some studies have found no differences in comfort [ 31 , 37 – 40 ] while others find similar corneal and conjunctival staining [ 38 , 40 – 43 ] among different lens care solutions. However, there are also studies that have found differences in comfort [ 11 , 41 , 44 ], corneal staining [ 11 , 25 , 44 – 47 ], and even in the amount of lens deposits [ 11 , 44 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Performance of Three Multipurpose Disinfecting Solutions with a Silicone Hydrogel Contact Lens

García-Porta

Rico-del-Viejo

Ferreira-Neves

et al. 2015

BioMed Research International

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Purpose. To evaluate the clinical performance of a silicone hydrogel (Si-Hy) soft contact lens (CL) in combination with three different multipurpose disinfecting solutions (MPDSs). Methods. This was a prospective, randomized, single-masked, crossover, and comparative study in which 31 habitual soft CL wearers were randomly assigned to one of the three MPDSs (Synergi, COMPLETE RevitaLens, and OPTI-FREE PureMoist) for 1 month with a 1-week wash-out period between each exposure. All subjects were successfully refitted with a Si-Hy CL (Biofinity). Subjects were then scheduled for follow-up visits after 1 month of lens wear, being evaluated at 2 and 8 hours after lens insertion. Visual Analogue Scales (VAS) were used to gauge comfort rating. Results. The tarsal conjunctiva showed a significantly different degree of lid redness between the MPDSs at the 2-hour visit (P < 0.05, Kruskal-Wallis test), being lower for COMPLETE RevitaLens compared to the other two MPDSs (Mann-Whitney U test). Furthermore, a significantly different degree of lid roughness at the 8-hour visit was seen (P < 0.05, Kruskal-Wallis test), being higher for Synergi (Mann-Whitney U test). The subjective comfort was similar with the three MPDSs. Conclusion. Tarsal conjunctival response should be also considered in the context of the clinical performance of MPDs at the ocular surface.

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“…Multipurpose solutions (MPSs) used for soft contact lens care contain agents, which can produce alterations in the tear film and ocular surface, such as keratitis, dry eye or conjunctivitis [1,2] Currently, the objective in the contact lens industry is to create novel formulations of MPSs with new agents in order to improve the ocular heath, comfort and to avoid discontinuing contact lens wear [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect on Corneal Surface of Multipurpose Soft Contact Lens Solution Which Contains Aloe Vera

Pintor

Martn-Gil²,

Carracedo³

et al. 2014

Biochem & Pharmacol

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Ocular tolerance of a new multipurpose solution specifically formulated for daily wear of silicone hydrogel contact lenses

Cited by 4 publications

References 22 publications

Biocompatibilidad con la superficie ocular y actividad antimicrobiana de una nueva solución multipropósito para lentes de contacto

Biocompatibilidad con la superficie ocular y actividad antimicrobiana de una nueva solución multipropósito para lentes de contacto

Performance of Three Multipurpose Disinfecting Solutions with a Silicone Hydrogel Contact Lens

Cytotoxic Effect on Corneal Surface of Multipurpose Soft Contact Lens Solution Which Contains Aloe Vera

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