Ocular syphilis in Victoria: four new cases and a brief discussion of the current Victorian experience

Amaratunge, Bhagya Chathri; Hall, Anthony J.

doi:10.1111/j.1442-9071.2008.01684.x

Cited by 9 publications

(10 citation statements)

References 2 publications

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“…Twenty-five to 50% of patients with ocular syphilis have no other clinical general signs [3,35]. Finally, high-risk sexual behaviors [13], HIV coinfection (33%) [3], or a previous history of syphilis infection (46%) [17] are key elements to guide the diagnosis, as underscored in our study.…”

Section: Discussionmentioning

confidence: 78%

Ocular manifestations of syphilis: recent cases over a 2.5-year period

Puech

Gennai

Pavèse

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 78%

Ocular manifestations of syphilis: recent cases over a 2.5-year period

Puech

Gennai

Pavèse

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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“…One hundred and forty‐three original descriptions of patients with syphilitic uveitis were identified. These cases were identified in 41 different papers 2,6,7,9–11,14,17–52 …”

Section: Resultsmentioning

confidence: 99%

Syphilitic uveitis: a review of clinical manifestations and treatment outcomes of syphilitic uveitis in human immunodeficiency virus‐positive and negative patients

Amaratunge

Camuglia

Hall

2010

Clinical Exper Ophthalmology

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136

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The incidence of syphilis and syphilitic uveitis in our community is increasing. The prevalence of associated neurosyphilis is unknown, and it remains unclear whether syphilitic uveitis should be treated as secondary syphilis with intramuscular penicillin or neurosyphilis with intravenous penicillin. The (English language) literature was reviewed for all unique cases of syphilitic uveitis reported from 1984 to June 2008. For each case the following data were recorded: the clinical features of the syphilis, the uveitis and any associated neurosyphilis, the human immunodeficiency virus (HIV) status, lumbar puncture findings, treatment and follow up. We identified 143 patients in 41 original reports of syphilitic uveitis (93 HIV-positive and 50 HIV-negative). Posterior uveitis was reported in 79 patients (55.2%); panuveitis was reported in 36 patients (25.2%); anterior/intermediate uveitis was reported in only 28 patients (19.6%). Lumbar puncture findings were abnormal in 82 patients (57%), and the majority of these patients (76%, 62 out of 82) were HIV-positive. One hundred and ten (77%) patients were treated with intravenous therapy, usually penicillin. Most recovered from the syphilis, however, a proportion did not recover full vision. There were 13 (9%) treatment failures, which tended to occur in patients who were HIV-positive (n = 11), had abnormal lumbar puncture findings (n = 8) and/or were treated (n = 11) intravenously. There is a high incidence of abnormal lumbar puncture findings in patients with syphilitic uveitis and a strong association with HIV infection. Most received appropriate therapy with a low relapse rate, which was not related to the type of therapy.

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“…Perioptic neuritis describes inflammatory involvement of the optic nerve sheath without inflammation of the nerve itself. The affected eye often has normal visual acuity with no visual field defect except for an enlarged blind spot 2 , 3 …”

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confidence: 99%