Ocular surgery after herpes simplex and herpes zoster keratitis

Kanclerz, Piotr; Alió, Jorge L.

doi:10.1007/s10792-020-01539-6

Cited by 12 publications

(5 citation statements)

References 98 publications

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“…15–17 The combination of surgical trauma along with the topical corticosteroid treatment commonly prescribed postoperatively may trigger reactivation. 18…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17] The combination of surgical trauma along with the topical corticosteroid treatment commonly prescribed postoperatively may trigger reactivation. 18 Oral antiviral prophylaxis is important for decreasing the risk for HSV ocular disease. 19 The American Academy of Ophthalmology recommends that antiviral prophylaxis be strongly considered for all patients with a history of HSV ocular disease in the immediate perioperative period, especially while being treated with corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

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Cataract surgery in herpes simplex virus ocular disease

Al-Ani

Meyer

et al. 2022

J Cataract Refract Surg

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“…15–17 The combination of surgical trauma along with the topical corticosteroid treatment commonly prescribed postoperatively may trigger reactivation. 18…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cataract surgery in herpes simplex virus ocular disease

Al-Ani

Meyer

et al. 2022

J Cataract Refract Surg

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“…Patients with a history of ocular herpetic keratitis should be avoided because of the risks of Herpes simplex virus recurrence that may, in turn, give rise to endothelial decompensation, corneal scarring, and surgical failure. 11,12 Furthermore, patients with a glaucoma shunt may be suboptimal candidates because the shunt can decrease the efficiency of the air bubble in the anterior chamber and thus interfere with the device attachment.…”

Section: Surgical Technique Patient Selectionmentioning

confidence: 99%

Implantation of an Artificial Endothelial Layer for Treatment of Chronic Corneal Edema

Auffarth

Son

Koch

et al. 2021

Cornea

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The purpose of this study was to describe a novel device that may serve as an alternative to Descemet membrane endothelial keratoplasty (DMEK) for the treatment of chronic corneal edema. Methods:The EndoArt (EyeYon Medical, Israel) is a flexible, 50mm thin artificial endothelial layer that matches the cornea's posterior curvature and functions as a fluid barrier at the posterior stroma, replacing the diseased endothelium. Similar to a DMEK approach, it is implanted into the anterior chamber, carefully positioned on the posterior stroma, and secured using an air-gas mixture. Two patients with chronic corneal edema resulting from endothelial decompensation underwent implantation of the new artificial lamella. Results:In patient 1, the central corneal thickness (CCT) decreased from 730 mm preoperatively to 593 mm at 1 day postoperatively. In patient 2, the CCT decreased from 761 mm preoperatively to 487 mm at 1 day postoperatively. Both patients reported high satisfaction and an overall brighter visual quality. Although dislocation of the lamella occurred in both cases, the CCT was promptly restored after a repositioning procedure and remained stable at the 17-month followup (CCT of 526 and 457 mm for patients 1 and 2, respectively). In contrast to DMEK donor tissue, the artificial lamella is sufficiently robust to allow easy intraocular manipulation without the risk of damaging the implant. It is easily removable and does not require any immunosuppressive treatment because of its nonbiological nature.Conclusions: Implantation of the EndoArt led to rapid corneal deturgescence and CCT restoration, presenting a possible option for patients with chronic corneal edema.

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“…Corneal transplantation is recommended for HSK-induced corneal leucoma or perforation. However, the postoperative prognosis is compromised by high rates of virus recurrence ( 10 ). According to previous studies, there is a high incidence of herpetic keratitis recurrence following penetrating keratoplasty (PK) - even with the topical acyclovir, the recurrent rate is still over 55% ( 10, 11 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, the postoperative prognosis is compromised by high rates of virus recurrence (10). According to previous studies, there is a high incidence of herpetic keratitis recurrence following penetrating keratoplasty (PK) -even with the topical acyclovir, the recurrent rate is still over 55% (10,11). Various studies have reported the recurrence rate of HSV infection in grafts with prophylactic oral acyclovir therapy ranging from 12% to 33% (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

In Vivo CRISPR Gene Editing in Patients with Herpes Stromal Keratitis

Wei

Yin

Zhai

et al. 2023

Preprint

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In vivo CRISPR gene therapy holds large clinical potential, but the safety and efficacy remain largely unknown. Here, we injected a single dose of HSV-1-targeting CRISPR formulation in the cornea of three patients with severe refractory herpes stromal keratitis (HSK) during corneal transplantation. Our study is an investigated initiated, open-label, single-arm, non-randomized interventional trial at a single center (NCT04560790). We found neither detectable CRISPR-induced off-target cleavages by GUIDE-seq nor systemic adverse events for 18 months on average in all three patients. The HSV-1 remained undetectable during the study. Our preliminary clinical results suggest that in vivo gene editing targeting the HSV-1 genome holds acceptable safety as a potential therapy for HSK.

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Ocular surgery after herpes simplex and herpes zoster keratitis

Cited by 12 publications

References 98 publications

Cataract surgery in herpes simplex virus ocular disease

Cataract surgery in herpes simplex virus ocular disease

Implantation of an Artificial Endothelial Layer for Treatment of Chronic Corneal Edema

In Vivo CRISPR Gene Editing in Patients with Herpes Stromal Keratitis

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