Ocular Surface Neoplasia Masquerading as Chronic Blepharoconjunctivitis

Abstract

Although uncommon, ocular surface malignancies may involve the conjunctiva diffusely and present as chronic conjunctivitis. A high index of suspicion and an early histopathologic examination are essential to not delay diagnosis.

Invasive Squamous Cell Carcinoma of the Conjunctiva First Misdiagnosed as a Pterygium: A Clinicopathologic Case Report

“…Similarly, Degrassi et al 7 presented a case report in which the pathologic examination of an apparent pterygium showed the presence of CIN in a 53-year-old man. In another study, Akpek et al 8 showed that ocular surface malignancies may involve the conjunctiva diffusely and present as chronic conjunctivitis. Olasode et al, 9 in their case presentation that reported invasive SCC initially diagnosed as an inflamed pterygium, stressed that a high index of suspicion is crucial to prevent a delay in the diagnosis of an invasive condition and not to cause complete involvement of the eye.…”

Isolated conjunctival lymphoma metastasis from previous low grade non-Hodgkin’s lymphoma

“…1 2 Primary conjunctival lymphomas often appear to masquerade for many months as conjunctivitis and a number of misdiagnoses have been reported. [3][4][5] Differential of the most common and important conjunctival lesions includes includes pterygium, pingecula, papilloma, kaposi's sarcoma, lymphoid tumours, limbal dermoid, dermolipoma, lymphangioma, granuloma, amelanotic melanoma, amyloid, and sebaceous cell carcinoma. Referral to an ophthalmologist is mandatory for ocular assessment, and neoplastic diagnoses should lead to systemic investigation including CT scans.…”

“…1 These tumours are often small, remain localised, and may therefore be asymptomatic. While primary conjunctival lymphoid tumours are well described 2 3 and may even affect both eyes, 4 conjunctival metastasis from systemic spread seems to be rare. 1 In addition, most cases of lymphoma involving tissues in and around the eye are low or intermediate grade and, considered to be of mucosal associated lymphoid tissue origin.…”

Oküler Yüzey Skuamöz Neoplazilerinde Yeni Gelişmeler

“…Aynı zamanda yaygın neoplazilerde preoperatif tümör sınırlarının küçülmesini sağlayarak tam cerrahi eksizyonu mümkün kılabilir. 11,[21][22][23][24][25][26] Florourasil Primidin analoğu olan 5FU hücre siklusunun S fazında DNA sentezini bloke etmek sureti ile etki gösterir. Hızlı proliferasyon gösteren hücreler üzerine etkisi nedeni ile epitel kökenli birçok kanser türünün tedavisinde kullanılmaktadır.…”