Ocular Sporotrichosis

Ribeiro, Camila Rodrigues; Silva, Bianca Portal; Costa, Amanda de Alcantara Almeida; Neto, Alberto Basile; Vieira, Luiz Henrique Palucci; Lima, Mônica Aparecida de; Lima, Mário Henrique Camargos de

doi:10.1016/j.ajoc.2020.100865

Cited by 10 publications

(10 citation statements)

References 13 publications

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“…In this study, we identified individuals with a broad spectrum of clinical presentation, highlighting from this study the high prevalence of individuals with ocular CTS (13%). Ocular forms may occur due to contact with secretions of sick felines in the conjunctiva, demonstrating that zoonotic transmission has altered the observed profile of clinical manifestations 8,27–29 . We observed high sensitivity (92%) for the diagnosis of ocular CTS using the Anti‐Sporo LFA.…”

Section: Discussionmentioning

confidence: 74%

A lateral flow assay for the immunodiagnosis of human cat‐transmitted sporotrichosis

Cognialli

Bloss

Weiss

et al. 2022

Mycoses

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Background Cat‐transmitted sporotrichosis (CTS) caused by Sporothrix brasiliensis has emerged as an important zoonosis in Brazil and neighbouring countries. Objectives Evaluate the performance of a lateral flow assay (LFA) for the detection of anti‐Sporothrix antibodies in human sera. Methods A LFA for the detection of anti‐Sporothrix antibodies (Anti‐Sporo LFA) in human sera, developed by IMMY, was evaluated using 300 human sera collected prospectively at the Hospital de Clínicas, Federal University of Paraná (HC‐UFPR), in Curitiba, Brazil. These specimens included 100 sera from patients with CTS. CTS cases were classified as follows: 59 lymphocutaneous, 27 fixed cutaneous,13 ocular, and one mixed form. One‐hundred specimens from patients with other mycoses, including cryptococcosis (n = 32), candidemia (n = 27), paracoccidioidomycosis (n = 14), aspergillosis (n = 10), histoplasmosis (n = 9), fusariosis (n = 4), lobomycosis (n = 1), chromoblastomycosis (n = 1), mucormycosis (n = 1) and trichosporonosis (n = 1). And 100 specimens from apparently healthy volunteers (AHV). Results The Anti‐Sporo LFA showed a global sensitivity of 83% (95% confidence interval [CI] = 74%–90%), a global specificity of 82% (95% CI = 76%–87%), and accuracy of 82% (95% CI = 77%–86%). By clinical form sensitivity was as follows: Mixed form 100%, ocular 92%, lymphocutaneous 83% and fixed cutaneous 78%. False‐positive results were observed in 11 specimens from people with other mycoses and 26 specimens from AHV. Conclusion and discussion This study presents the results of the evaluation of the first lateral flow assay for the detection of anti‐Sporothrix antibodies in human sera. The findings here show evidence that IMMY's Anti‐Sporo LFA is a promising tool for the rapid diagnosis of CTS.

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Section: Discussionmentioning

confidence: 74%

A lateral flow assay for the immunodiagnosis of human cat‐transmitted sporotrichosis

Cognialli

Bloss

Weiss

et al. 2022

Mycoses

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“…Twenty-one studies (case reports and case series) reported ocular sporotrichosis with involvement of the conjunctiva, representing a total of 56 patients, with a mean age of 33.33 ± 21.81 years (range 3-80 years) (Table 3) [34,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]. Most cases have been reported in Brazil (44 cases) and Malaysia (8 cases).…”

Section: Conjunctival Sporotrichosismentioning

confidence: 99%

“…The left eye was more commonly affected than the right one (15 vs. 12 cases, respectively), although in 29 cases, the affected eye was not specified. S. schenckii was isolated in 25% of the cases (14 patients) [39][40][41]44,47,[50][51][52][53] followed by S. brasiliensis (5.3%, 3 cases) [26,45]; isolation was not achieved in 4 patients (7.4%) [3,4,7,11], and in 35 (62.5%), the species involved was not determined [12,34,37,38,43,49]. Previous trauma related to conjunctival implantation was not reported in any patient, although contact with cats was reported in 50 patients (89.3%) (Table 3) [26,34,37,38,40,41,[43][44][45][46][47][48][49][50][51][52][53].…”

Section: Conjunctival Sporotrichosismentioning

confidence: 99%

“…yeasts are made with direct or fresh examination with conventional stains including Giemsa, PAS, and Grocott (KOH (10%) or NaOH (4%) is rarely used due to poor results); the observation of yeast in cigar-shaped buds or small boats is characteristic, but infrequently seen (5-10%), except in disseminated cases and immunosuppressed patients. Cat and dog cases have many yeasts; however, this is frequent only in the ocular conjunctiva samples in human subjects [1,5,10,12,47].…”

Section: Laboratory Diagnosismentioning

confidence: 99%

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Ocular Sporotrichosis

Ramírez-Soto

Tirado‐Sánchez

Bonifáz

2021

JoF

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Sporotrichosis is a subacute or chronic mycosis predominant in tropical and subtropical regions. It is an infection of subcutaneous tissue caused by Sporothrix fungus species, but occasionally resulting in an extracutaneous condition, including osteoarticular, pulmonary, nervous central system, and ocular disease. Cases of ocular sporotrichosis are rare, but reports have been increasing in recent decades. Ocular infections usually occur in hyperendemic areas of sporotrichosis. For its classification, anatomic criteria are used. The clinical presentation is the infection in the ocular adnexal and intraocular infection. Ocular adnexa infections include palpebral, conjunctivitis, and infections of the lacrimal sac. Intraocular infection includes exogenous or endogenous endophthalmitis. Most infections in the ocular adnexal have been reported in Brazil, China and Peru, and intraocular infections are limited to the USA and Brazil. Diagnosis is performed from Sporothrix isolation in the mycological examination from ocular or skin samples. Both sporotrichosis in the ocular adnexa and intraocular infection can mimic several infectious and non-infectious medical conditions. Ocular adnexa infections are treated with potassium iodide and itraconazole. The intraocular infection is treated with amphotericin B. This review describes the clinical findings and epidemiological, diagnosis, and treatment of ocular sporotrichosis.

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“…Ocular fungal infections have been reported to be caused by more than 56 genera. Among these, the most commonly involved are Candida and Aspergillus ; other unicellular and filamentous fungi such as Fusarium , Penicillium, Paecilomyces , Acremonium , Exophiala , Pseudallescheria , Scytalidium , Sporothrix , and Cryptococcus ; and dimorphic fungi [ 12 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

First Report of a Case of Ocular Infection Caused by Purpureocillium lilacinum in Poland

et al. 2021

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This report describes the first case of an ocular infection induced by Purpureocillium lilacinum in Poland. The patient was a 51-year-old immunocompetent contact lens user who suffered from subacute keratitis and progressive granulomatous uveitis. He underwent penetrating keratoplasty for corneal perforation, followed by cataract surgery due to rapid uveitic cataract. A few weeks later, intraocular lens removal and pars plana vitrectomy were necessary due to endophthalmitis. The patient was treated with topical, systemic, and intravitreal voriconazole with improvement; however, the visual outcome was poor. The pathogen was identified by MALDI-TOF MS.

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Ocular Sporotrichosis

Cited by 10 publications

References 13 publications

A lateral flow assay for the immunodiagnosis of human cat‐transmitted sporotrichosis

A lateral flow assay for the immunodiagnosis of human cat‐transmitted sporotrichosis

Ocular Sporotrichosis

First Report of a Case of Ocular Infection Caused by Purpureocillium lilacinum in Poland

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