Ocular Sensations and Symptoms Associated With Tear Break-Up.

The Interblink Interval I: The Relationship between Sensation Intensity and Tear Film Disruption

“…25,26 Recently, ocular surface drying occurring during forced eye opening has been used to elicit acute discomfort in an attempt to understand corneal sensations in provoked dry eye. [27][28][29] We used this as a point of departure to characterize the dynamics of tear film drying and describe the nature of the associated changing sensations.…”

“…25,26 Recently, ocular surface drying occurring during forced eye opening has been used to elicit acute discomfort in an attempt to understand corneal sensations in provoked dry eye. [27][28][29] We used this as a point of departure to characterize the dynamics of tear film drying and describe the nature of the associated changing sensations.With a view toward simultaneously acquire the intensity and qualitative attributes of sensations produced during forced eye opening and to quantify the tear film drying during this interval, we developed an instrument to acquire continuous ratings of intensity, spoken attributes of sensations, and images of fluorescein patterns of tear breakup and surface drying when blinks were voluntarily suppressed. …”

The lid wiper and muco-cutaneous junction anatomy of the human eyelid margins: an in vivo confocal and histological study

“…When considering the role of tears, the primary foci are usually the glandular secretions, which represent the tears, and the lubricative mucins of the ocular surface epithelia, which serve to adhere the tears to the ocular surface (Holly & Lemp, 1971;Jumblatt & Jumblatt, 1998;Argueso & Gipson, 2001;Cher, 2008). The lid margins, however, are the prerequisite for the thin spread of a stable tear film and its re-formation with every blink, to achieve a thin, optically perfect tissue-air interface (Lemp, 1981;Korb et al 1994;Tsubota & Nakamori, 1995;Begley et al 2002;Nichols et al 2002;King-Smith et al 2004;Millar et al 2006;Paugh et al 2008).…”