Ocular sarcoidosis: when should labial salivary gland biopsy be performed?

Abstract

In this study, the LSGB sensitivity (18.75 %) in the patients with proven sarcoidosis appears to be lower than in other reports. Our results suggest that this investigation is a possible method of tissue diagnosis in patients with raised ACE and/or CT scan pattern compatible with sarcoidosis, and should not be performed in patients with unexplained uveitis or because of their ophthalmological features.

Tattoo‐associated uveitis with or without systemic sarcoidosis: a comparative review of the literature

“…There is a need for other biomarkers in sarcoidosis, such as chitotriosidase for instance . In some circumstances, biopsy of minor salivary glands can be of help . Lastly, 18 F‐FDG PET scanner could also have a place in case of undetermined uveitis as it may reveal focal up‐take suggestive of sarcoidosis and guide the choice of a biopsy site …”

“…1,42 In some circumstances, biopsy of minor salivary glands can be of help. 43 Lastly, 18 F-FDG PET scanner could also have a place in case of undetermined uveitis as it may reveal focal up-take suggestive of sarcoidosis and guide the choice of a biopsy site. 1,44 Therefore, it is important to stress that most of the reported cases of tattoo-associated isolated uveitis without sarcoidosis could have been underexplored for sarcoidosis.…”

Relevance of diagnostic investigations in patients with uveitis: Retrospective cohort study on 300 patients

“…12,13 . Deux études françaises suggèrent que la biopsie des glandes salivaires accessoires, même si souvent pratiquée dans de nombreux centres, semble avoir une performance très limitée (sensibilité entre 3 et 5%) 14,15 . Enfin, la lymphocytose alvéolaire au lavage broncho-alvéolaire réalisé lors d'une fibroscopie bronchique semble également présenter un intérêt pour le diagnostic de sarcoïdose oculaire [16][17][18] .…”

Uveitis: Diagnostic work-up. A literature review and recommendations from an expert committee

“…Two studies have recently reported the interest of BMSG for the histologic diagnosis of sarcoidosis in uveitis patients [130,131]. The positivity rate was 5.2 and 3%, respectively, in these two studies.…”