Ocular Sarcoidosis in a Korean Population

ABSTRACT.Purpose: To investigate the prognosis and complications in patients with peripheral multifocal chorioretinitis (PMC). PMC is a posterior or panuveitis characterized by chronic bilateral vitritis and punched-out lesions in the peripheral retina which occurs commonly in elderly white women and is associated with sarcoidosis. Prognosis and complications are largely unknown. Methods: A structured literature search in PubMed, Embase and Cochrane was performed to identify relevant articles. Articles were screened, and the remaining articles were critically appraised based on relevance and validity. Results: The search yielded 267 articles. Eight relevant articles were retrieved. All studies reported on moderate visual impairment. Macular oedema occurred in 60% of the patients with PMC (range, 0-71%), glaucoma in 27% (range, 25-43%) and an epiretinal membrane in 21% (range, 0-28%). In total, 47% had proven or presumed sarcoidosis. Treatment usually comprised topical corticosteroids, periocular steroid injections and systemic corticosteroids regularly in combination with methotrexate. Conclusion: The prognosis of patients with PMC is characterized by a rather poor visual outcome and the relatively high prevalence of complications. PMC is strongly associated with sarcoidosis. Solid proof for the treatment efficacy of PMC is lacking.

show abstract

“…1996). PMC subjects had worse visual outcome than patients with other ocular manifestations of sarcoidosis (Lee et al. 2009).…”

Section: Discussionmentioning

confidence: 99%

Peripheral multifocal chorioretinitis

Koop

Ossewaarde

Rothová

2012

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…method for the quantitative measurement of cyclotropia in the strabismus clinic (Madigan & Katz 1992;Lee et al 2004;Lee & Lee 2005). The effect of static ocular counter roll, a compensatory torsional eye movement during head tilt, is reported to be kept within 1°, provided head tilt was <5° (Felius et al 2009).…”

Section: Commentsmentioning

confidence: 99%

“…In the normal population, the optic disc is located 6.3 AE 3.0°v ertically above the fovea (Madigan & Katz 1992;Williams & Wilkinson 1992;Rohrschneider 2004;Hood et al 2013). In Korean population, the disc-foveal angle is reported to 6.5 AE 2.9°, which was reported to be unaffected by laterality and sex, or age (Lee et al 2004;Lee & Lee 2005). There was considerable variation in the normal disc-foveal angle, and most values were positive, which indicates that the fovea is positioned below the optic disc.…”

Section: Commentsmentioning

confidence: 99%

Difference in the posterior pole profiles associated with the initial location of visual field defect in early‐stage normal tension glaucoma

Choi

Park

2014

Acta Ophthalmologica

View full text Add to dashboard Cite

ABSTRACT.Purpose: To identify the differences in posterior pole profiles between early normal tension glaucoma (NTG) patients with an initial central visual field (VF) loss and those with a peripheral VF loss. Methods: Normal tension glaucoma patients with parafoveal scotoma (PFS; within a central 10°of fixation; superior, n = 47; inferior, n = 24) and peripheral nasal step (PNS; VF defect in the nasal meridian outside 10°of fixation; superior, n = 27; inferior, n = 32) in either hemifield were enrolled, if their mean deviation was greater than À10 decibels (dB). Disc tilt (tilt ratio), disc torsion, area of peripapillary atrophy and disc-foveal angle (angle between a horizontal line through the disc centre and the line connecting the fovea and the disc centre) were analysed from red-free fundus photographs. Results: The mean disc-foveal angles (shortest diameter) in PNS and PFS groups were 6.2 AE 4.5 and 7.7 AE 4.0°, respectively. In multivariate analysis, eyes with PFS were associated with a greater disc-foveal angle, compared with PNS (p = 0.042). In subgroup analysis, superior PFS group showed greater discfoveal angle compared with inferior PFS group (p = 0.018). In the PNS group, the direction of disc torsion was associated with superior and inferior hemifield defects (p = 0.004). Conclusions: The posterior pole profiles were different in NTG patients according to their location of damage. Disc-foveal angle was the major determinant of the VF location in patients with VF loss at the central region and disc torsion in patients with loss at the peripheral region.

show abstract

“…4,34 Clinical features include vitritis and haze, sting of pearls vitreous opacities, snowballs, and snowbanking. Complications include cystoid macular edema (CME) and retinal vasculitis.…”

Section: ' Ocular Manifestationsmentioning

confidence: 99%