Ocular rosacea. Signs, symptoms, and tear studies before and after treatment with doxycycline

Quarterman, Mark J.; Johnson, David W.; Abele, Donald C.; Lesher, Jack L.; Hull, D; Davis, Loretta S.

doi:10.1001/archderm.133.1.49

Cited by 53 publications

(42 citation statements)

References 16 publications

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“…Active MMP-8 was in practice present only in the OcR samples, but 8 weeks of oral doxycycline treatment reduced MMP-8 activation. On the right, human PMN extracts and human synovial fibroblast culture medium were used as positive controls to distinguish the MMP-8 isoforms previous papers [8,28]. Dry eye syndrome is a hallmark of the disease, and doxycycline has been shown to increase TBUT [28].…”

Section: Discussionmentioning

confidence: 99%

“…Ocular rosacea (OcR) is a long-standing disease, characterized by lid margin telangiectasia, meibomian gland inflammation and inspissation, and conjunctival hyperemia commonly leading to symptoms and signs of dry eye [28]. Advanced OcR can lead to peripheral ulcerative keratitis (PUK) and corneal vascularization [for review, see 3].…”

Section: Introductionmentioning

confidence: 99%

“…Tetracyclines improve tear break-up time (TBUT) and relieve symptoms [8,28]. Nonetheless, it is unclear how exactly they improve OcR.…”

Section: Introductionmentioning

confidence: 99%

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Tear fluid levels of MMP-8 are elevated in ocular rosacea—treatment effect of oral doxycycline

Määttä

Kari

Tervahartiala

et al. 2006

Graefe's Arch Clin Exp Ophthalmo

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tear fluid levels of MMP-8 are elevated in ocular rosacea—treatment effect of oral doxycycline

Määttä

Kari

Tervahartiala

et al. 2006

Graefe's Arch Clin Exp Ophthalmo

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“…But approximately half of the patients develop skin lesions first. Ocular symptoms range from a sensation of dryness to burning or stinging, itching, light sensitivity and blurred vision [56]. Blepharitis and conjunctivitis are the most common findings in patients with ocular rosacea (fig.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Tetracycline and doxycycline are commonly used in the treatment of ocular rosacea [6, 80]. Doxycycline 100 mg daily for 12 weeks significantly improves signs and symptoms of ocular disease [56]. Patients may remain in remission for several months at a time.…”

Section: Systemic Therapymentioning

confidence: 99%

Rosacea: An Update

Buechner¹

2005

Dermatology

118

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Rosacea is a common chronic cutaneous disorder of unknown etiology which occurs most commonly in middle-aged individuals. Cutaneous manifestations include transient or persistent facial erythema, telangiectasia, edema, papules and pustules that are usually confined to the central portion of the face. The National Rosacea Society’s Expert Committee on the Classification and Staging of Rosacea identified four subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous and ocular. Recently, a standard grading system for assessing gradations of the severity of rosacea has been reported. Little is known about the cause of rosacea. Genetic, environmental, vascular, inflammatory factors and microorganisms such as Demodex folliculorum and Helicobacter pylori have been considered. Topical metronidazole and azelaic acid have been demonstrated to be effective treatments for rosacea. Severer or persistent cases may be treated with oral metronidazole, tetracyclines or isotretinoin.

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