Ocular rosacea: a review

Vieira, Ana Carolina; Höfling-Lima, Ana Luísa; Mannis, Mark J.

doi:10.1590/s0004-27492012000500016

Cited by 80 publications

(100 citation statements)

References 68 publications

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“…There are probably different regulatory systems involved [3][4][5]22] . The infection by microbial organisms may have an important role.…”

Section: Etiology Pathophysiology and Histopathologymentioning

confidence: 99%

“…The infection by microbial organisms may have an important role. In OR, Demodex folliculorum mites, a common inhabitant of normal human skin, possibly represents a contributing cofactor to the inflammatory reaction seen in both cutaneous and ocular disease [2][3][4]22,23] . Recently, bacterium Bacillus oleronius has been isolated from Demodex folliculorum mites and found to be responsible to trigger an immune system response.…”

Section: Etiology Pathophysiology and Histopathologymentioning

confidence: 99%

“…Rosacea is a chronic condition affecting the facial and ocular surface tissues, particularly common in the fairskinned population [1][2][3][4] . The American National Rosacea Society developed a classification system that became the standard one.…”

Section: Introductionmentioning

confidence: 99%

“…According to the patterns of signs and symptoms, four major clinical subtypes of rosacea are described: Erythematotelangiectatic, papulopustular, phymatous and ocular rosacea. In children, the phymatous type is not seen [1][2][3][4] . These subtypes may be discrete variants or may be progressive from one to another, and they can also coexist.…”

Section: Introductionmentioning

confidence: 99%

“…These subtypes may be discrete variants or may be progressive from one to another, and they can also coexist. Ocular rosacea is one of the four described types of rosacea, characterized by involvement of eyelids, conjunctiva and corneal tissue [1][2][3][4] . The prevalence of ophthalmic involvement in rosacea is probably higher than previously presumed and it varies considerably between ophthalmic and dermatological studies [2,3,5] .…”

Section: Introductionmentioning

confidence: 99%

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Pediatric ocular rosacea, a misdiagnosed disease with high morbidity: Proposed diagnostic criteria

Arriaga¹,

Domingues²,

Castela³

et al. 2016

WJD

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Ocular rosacea is an important and underdiagnosed chronic inflammatory disorder observed in children. A clinical spectrum ranging from chronic eyelid inflammation, recurrent ocular redness, photophobia and/or hordeola/chalazions and conjunctival/corneal phlyctenules evolving to neovascularization and scarring may occur. Visual impairment and consequent amblyopia are frequent and corneal perforation although rare is the most feared complication. Ocular manifestations usually precede cutaneous lesions. Although few cases of pediatric ocular rosacea (POR) have been reported in the literature, many cases must have been underdiagnosed or misdiagnosed. The delay in diagnosis is greater than one year in the large majority of cases and may lead to serious ocular sequelae. This review aims to highlight the clinical features of POR, its epidemiology, easy diagnosis and effective treatment. We also propose new diagnostic criteria, in which at least three of the five clinical criteria must be present: (1) Chronic or recurrent keratoconjunctivitis and/or red eye and/or photophobia; (2) Chronic or recurrent blepharitis and/or chalazia/ hordeola; (3) Eyelid telangiectasia documented by an ophthalmologist; (4) Primary periorificial dermatitis and/ or primary features of rosacea; and (5) Positive familial history of cutaneous and/or ocular rosacea.

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“…There are probably different regulatory systems involved [3][4][5]22] . The infection by microbial organisms may have an important role.…”

Section: Etiology Pathophysiology and Histopathologymentioning

confidence: 99%

Section: Etiology Pathophysiology and Histopathologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pediatric ocular rosacea, a misdiagnosed disease with high morbidity: Proposed diagnostic criteria

Arriaga¹,

Domingues²,

Castela³

et al. 2016

WJD

View full text Add to dashboard Cite

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Association of Caffeine Intake and Caffeinated Coffee Consumption With Risk of Incident Rosacea in Women

Chen

Drucker

et al. 2018

JAMA Dermatol

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IMPORTANCE Caffeine is known to decrease vasodilation and have immunosuppressant effects, which may potentially decrease the risk of rosacea. However, the heat from coffee may be a trigger for rosacea flares. The relationship between the risk of rosacea and caffeine intake, including coffee consumption, is poorly understood. OBJECTIVE To determine the association between the risk of incident rosacea and caffeine intake, including coffee consumption. DESIGN, SETTING, AND PARTICIPANTS This cohort study included 82 737 women in the Nurses' Health Study II (NHS II), a prospective cohort established in 1989, with follow-up conducted biennially between 1991 and 2005. All analysis took place between June 2017 and June 2018. EXPOSURES Data on coffee, tea, soda, and chocolate consumption were collected every 4 years during follow-up. MAIN OUTCOMES AND MEASURES Information on history of clinician-diagnosed rosacea and year of diagnosis was collected in 2005. RESULTS A total of 82 737 women responded to the question regarding a diagnosis of rosacea in 2005 in NHS II and were included in the final analysis (mean [SD] age at study entry, 50.5 [4.6] years). During 1 120 051 person-years of follow-up, we identified 4945 incident cases of rosacea. After adjustment for other risk factors, we found an inverse association between increased caffeine intake and risk of rosacea (hazard ratio for the highest quintile of caffeine intake vs the lowest, 0.76; 95% CI, 0.69-0.84; P < .001 for trend). A significant inverse association with risk of rosacea was also observed for caffeinated coffee consumption (HR, 0.77 for those who consumed Ն4 servings/d vs those who consumed <1/mo; 95% CI, 0.69-0.87; P < .001 for trend), but not for decaffeinated coffee (HR, 0.80; 95% CI, 0.56-1.14; P = .39 for trend). Further analyses found that increased caffeine intake from foods other than coffee (tea, soda, and chocolate) was not significantly associated with decreased risk of rosacea. CONCLUSIONS AND RELEVANCE Increased caffeine intake from coffee was inversely associated with the risk of incident rosacea. Our findings do not support limiting caffeine intake as a means to prevent rosacea. Further studies are required to explain the mechanisms of action of these associations, to replicate our findings in other populations, and to explore the relationship of caffeine with different rosacea subtypes.

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Rosacea Core Domain Set for Clinical Trials and Practice

Dirr,

Ahmed,

Schlessinger

et al. 2024

JAMA Dermatol

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ImportanceInconsistent reporting of outcomes in clinical trials of rosacea is impeding and likely preventing accurate data pooling and meta-analyses. There is a need for standardization of outcomes assessed during intervention trials of rosacea.ObjectiveTo develop a rosacea core outcome set (COS) based on key domains that are globally relevant and applicable to all demographic groups to be used as a minimum list of outcomes for reporting by rosacea clinical trials, and when appropriate, in clinical practice.Evidence ReviewA systematic literature review of rosacea clinical trials was conducted. Discrete outcomes were extracted and augmented through discussions and focus groups with key stakeholders. The initial list of 192 outcomes was refined to identify 50 unique outcomes that were rated through the Delphi process Round 1 by 88 panelists (63 physicians from 17 countries and 25 patients with rosacea in the US) on 9-point Likert scale. Based on feedback, an additional 11 outcomes were added in Round 2. Outcomes deemed to be critical for inclusion (rated 7-9 by ≥70% of both groups) were discussed in consensus meetings. The outcomes deemed to be most important for inclusion by at least 85% of the participants were incorporated into the final core domain set.FindingsThe Delphi process and consensus-building meetings identified a final core set of 8 domains for rosacea clinical trials: ocular signs and symptoms; skin signs of disease; skin symptoms; overall severity; patient satisfaction; quality of life; degree of improvement; and presence and severity of treatment-related adverse events. Recommendations were also made for application in the clinical setting.Conclusions and RelevanceThis core domain set for rosacea research is now available; its adoption by researchers may improve the usefulness of future trials of rosacea therapies by enabling meta-analyses and other comparisons across studies. This core domain set may also be useful in clinical practice.

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Ocular rosacea: a review

Cited by 80 publications

References 68 publications

Pediatric ocular rosacea, a misdiagnosed disease with high morbidity: Proposed diagnostic criteria

Pediatric ocular rosacea, a misdiagnosed disease with high morbidity: Proposed diagnostic criteria

Association of Caffeine Intake and Caffeinated Coffee Consumption With Risk of Incident Rosacea in Women

Rosacea Core Domain Set for Clinical Trials and Practice

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