Ocular Permeation Enhancers

Kim, Nathaniel J.; Harris, Alon; Elghouche, Alhasan N.; Gama, Willy; Siesky, Brent

doi:10.1007/978-3-319-29346-2_9

Cited by 4 publications

(2 citation statements)

References 213 publications

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“…Unfortunately, it has to be noticed that most technological solu-tions on the nanoscale are only promising at the laboratory stage. The transfer of such technologies to an industrial scale is often complicated and causes many difficulties [72][73][74].…”

Section: Review 1 Introductionmentioning

confidence: 99%

Microneedle-based ocular drug delivery systems – recent advances and challenges

Gadziński¹,

Froelich²,

Wojtyłko³

et al. 2022

Beilstein J. Nanotechnol.

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Eye diseases and injuries constitute a significant clinical problem worldwide. Safe and effective delivery of drugs to the eye is challenging mostly due to the presence of ocular barriers and clearance mechanisms. In everyday practice, the traditional eye drops, gels and ointments are most often used. Unfortunately, they are usually not well tolerated by patients due to the need for frequent use as well as the discomfort during application. Therefore, novel drug delivery systems with improved biopharmaceutical properties are a subject of ongoing scientific investigations. Due to the developments in microtechnology, in recent years, there has been a remarkable advance in the development of microneedle-based systems as an alternative, non-invasive form for administering drugs to the eye. This review summarizes the latest achievements in the field of obtaining microneedle ocular patches. In the manuscript, the most important manufacturing technologies, microneedle classification, and the research studies related to ophthalmic application of microneedles are presented. Finally, the most important advantages and drawbacks, as well as potential challenges related to the unique anatomy and physiology of the eye are summarized and discussed.

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Section: Review 1 Introductionmentioning

confidence: 99%

Microneedle-based ocular drug delivery systems – recent advances and challenges

Gadziński¹,

Froelich²,

Wojtyłko³

et al. 2022

Beilstein J. Nanotechnol.

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show abstract

“…The complex ultrastructure of the cornea, enzymes, efflux proteins and the lymphatic and vascular systems, severely limits penetration of the therapeutic agent across the ocular tissues. Moreover, the ocular tissues are very sensitive; thus, the use of permeation enhancers is limited in ophthalmic formulations [11,12]. Therefore, there is a pressing need for advanced ophthalmic formulations to circumvent the challenges associated with topical ocular drug delivery.…”

mentioning

confidence: 99%

Recent Advances in Topical Nano drug-delivery Systems for the Anterior Ocular Segment

2018

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Over the past decade, there has been a rise in the number of clinical cases of moderate to severe anterior segment ocular diseases. Conventional topical ophthalmic formulations have several limitations - to address which, novel drug-delivery systems are needed. Additionally, formidable physiological barriers limit ocular bioavailability through the topical route of application. During the last decade, various nano-scaled ocular drug-delivery strategies have been reported. Some of these exploratory, topical, noninvasive approaches have shown promise in improving penetration into the anterior segment tissues of the eye. In this article, we review the available literature with respect to the safety, efficiency and effectiveness of these nano systems.

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