Ocular Penetration and Efficacy of Levofloxacin Using Different Drug-Delivery Techniques for the Prevention of Endophthalmitis in Rabbit Eyes with Posterior Capsule Rupture

Uda, Takahiro; Suzuki, Takashi; Mitani, Akira; Tasaka, Yoshitaka; Kawasaki, Shiro; Mito, Tsuyoshi; Ohashi, Yuichi

doi:10.1089/jop.2013.0204

Cited by 6 publications

(14 citation statements)

References 43 publications

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“…found that levofloxacin at a dose of 500 mg/ml was injected intravitreal directly did not cause signs of toxicity and no change of electroretinogram waves on rabbit retina was observed for 4 weeks. 18 …”

Section: Discussionmentioning

confidence: 99%

Safety of intracameral injection of levofloxacin 0.5% eye drops single dose 0.6 ml preservative free on rabbit eye

Edwar,

Bisara,

Setiabudi

et al. 2023

F1000Res

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Background This was an experimental, parallel, and randomized study to evaluate the safety of single intracameral injection of 0.6 ml 0.5% preservative-free levofloxacin eye drops on rabbit eye. Methods In total, 24 eyes of 12 New Zealand white rabbits were divided into three groups. The first group (LFX) was treated with 0.1 ml intracameral injection of levofloxacin 0.5% eye drops of 0.6 ml preservative-free (n = 6), the second group (CRAV) was treated with 0.1 ml intracameral injection of levofloxacin 0.5% eye drops 5 ml commercially available eye drops preservative-free (n = 6), and the third group (BSS) were treated with 0.1 ml intracameral injection of balanced salt solution (n = 12). All groups received a single dose. The clinical evaluation was performed on the 1st, 3rd, 5th, and 7th day after injection. Each eye was enucleated on the 7th day and underwent a histopathology examination. Results The clinical scores among the three groups did not show any significant difference on days 1st, 2nd, 3rd, and 7th (p>0.05). The only ones noted in clinical scores were mild corneal opacity, mild cells, and flares in the anterior chamber. The histopathology score demonstrated no statistically significant difference between the three groups (p>0.05). Vacuolization of corneal endothelial cells was noted in all groups but was not statistically significant. Conclusions A single intracameral injection of 0.6 ml 0.5% preservative-free levofloxacin eye drops was safe for rabbit eye, according to clinical and histopathology scores, similar to levofloxacin 0.5% eye drops in 5 ml bottle preservative free.

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Section: Discussionmentioning

confidence: 99%

Safety of intracameral injection of levofloxacin 0.5% eye drops single dose 0.6 ml preservative free on rabbit eye

Edwar,

Bisara,

Setiabudi

et al. 2023

F1000Res

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“…Due to its good penetration into the vitreous and excellent antimicrobial coverage against Bacillus , fluoroquinolones are widely used topically and systemically for the treatment and prophylaxis of endophthalmitis. Although the safety and efficacy of intraocular injection with fluoroquinolones, such as levofloxacin or moxifloxacin, have been evaluated in experimental endophthalmitis, [ 36 – 38 ] the efficacy of intraocular injection with fluoroquinolones has not been well established in human. However, 24.3% of respondents replied using fluoroquinolones as the first choice in this survey.…”

Section: Discussionmentioning

confidence: 99%

Survey of Intraocular Antibiotics Prophylaxis Practice after Open Globe Injury in China

et al. 2016

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PurposeTo elucidate the Chinese practice of intraocular antibiotics administration for prophylaxis after open globe injury.MethodsA cross-sectional questionnaire survey was performed online by scanning a Quickmark (QR) code with smartphones at the 20th Chinese National Conference of Ocular Trauma in November 2014.ResultsA total of 153 (30.6%) of all participators at the conference responded. Of the respondents, 20.9% were routinely administered with prophylactic intraocular injection of antibiotics at the conclusion of the primary eye repair, and 56.9% were used only in cases with high risk of endophthalmitis development. The intraocular route of delivery was mainly included with intracameral injection (47.9%) and intravitreal injection (42.0%). Cephalosporins (53.8%) and vancomycin (42.0%) were the main choices of antibiotic agents, followed by fluoroquinolones (24.3%), and aminoglycosides (13.4%). Only 21.9% preferred a combination of two or more two drugs routinely. In addition, significantly more respondents from the referral eye hospital (92.7%) replied using intraocular antibiotics injection for prophylaxis compared to those respondents from the primary hospital (69.4%) (p = 0.001, Fisher’s exact test).ConclusionsIntraocular antibiotics injection for post-traumatic endophthalmitis prophylaxis is widely used in China. However, the choice of antibiotic agents and the intraocular route of delivery vary. A well-designed clinical trial is needed to establish a standardized protocol of intraocular antibiotics administration for post-traumatic endophthalmitis prophylaxis.

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“…Causative bacterial species include Escherichia coli, P. aeruginosa, S. aureus, and Streptococcus faecalis. In general, to prevent and reduce endophthalmitis, topical antibiotic prophylaxis is administered immediately after and on the next day of surgery [18,[20][21][22]. Signs of bacterial endophthalmitis include pain, blurred vision, corneal edema, conjunctival hyperemia, and hypopyon.…”

Section: Bacterial Endophthalmitismentioning

confidence: 99%

“…Due to the larger pores and higher pores density, the conjunctival permeability to hydrophilic drugs is [15][16][17][18][19][20][21][22][23][24][25] fold that of the cornea [25]. Drugs permeation through the sclera is nearly half that of the conjunctiva [3].…”

Section: Barriers To Topical Ocular Drug Deliverymentioning

confidence: 99%

Topical Drug Delivery for Effective Treatment of Bacterial Infections of the Anterior Segment of the Eye

El-Bary

Ibrahim

Haza'a

2018

Asian J Pharm Clin Res

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Anterior parts of the eye are susceptible to infections caused by different bacterial species. The use of suitable therapeutic measures in case of ocular infections can be sight saving. The appropriate therapy depends on selecting the right antibacterial as well as an efficient drug delivery system. Despite their accessibility, topical delivery of the selected antibiotic into the anterior ocular parts is still a challenging issue due to the complex nature of the eye. Ocular therapy would be significantly improved by modifying the physicochemical properties of the drug and by prolonging its pre-corneal residence time. This review will help pharmaceutical formulators to identify different parts of the eye and the corresponding bacterial infections, ocular barriers to drug delivery, and general consideration when formulating ocular drug delivery systems for the treatment of eye infections.

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Ocular Penetration and Efficacy of Levofloxacin Using Different Drug-Delivery Techniques for the Prevention of Endophthalmitis in Rabbit Eyes with Posterior Capsule Rupture

Abstract: The LVFX IC was effective at suppressing endophthalmitis caused by E. faecalis in eyes with a PCR.

Cited by 6 publications

References 43 publications

Safety of intracameral injection of levofloxacin 0.5% eye drops single dose 0.6 ml preservative free on rabbit eye

Safety of intracameral injection of levofloxacin 0.5% eye drops single dose 0.6 ml preservative free on rabbit eye

Survey of Intraocular Antibiotics Prophylaxis Practice after Open Globe Injury in China

Topical Drug Delivery for Effective Treatment of Bacterial Infections of the Anterior Segment of the Eye

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