Ocular Oscillometry in Cerebrovascular Disease

Lester, Harvey A.

doi:10.1001/archopht.1966.03850010393018

Cited by 15 publications

(3 citation statements)

References 19 publications

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“…The measurement of OPA is a reasonably old method and has been performed by several investigators over the past century on humans and various animal species ( Thiel, 1928 ; Susuki, 1962 ; Bynke and Krakau, 1964 ; Lawrence and Schlegel, 1966 ; Lester, 1966 ; Bynke, 1968 ). The reliability of ocular pulse pressure waves measured with a pneumatic tonometer has been previously documented in dogs, confirmed with manometric systems, and compared to humans and rabbits ( Tonjum, 1972 ).…”

Section: Discussionmentioning

confidence: 99%

Ocular pulse amplitude (OPA) in canine ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

Raphtis,

Sharma,

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: The role of ocular rigidity and biomechanics remains incompletely understood in glaucoma, including assessing an individual’s sensitivity to intraocular pressure (IOP). In this regard, the clinical assessment of ocular biomechanics represents an important need. The purpose of this study was to determine a possible relationship between the G661R missense mutation in the ADAMTS10 gene and the ocular pulse amplitude (OPA), the difference between diastolic and systolic intraocular pressure (IOP), in a well-established canine model of open-angle glaucoma (OAG).Methods: Animals studied included 39 ADAMTS10-mutant dogs with different stages of OAG and 14 unaffected control male and female dogs between 6 months and 12 years (median: 3.2 years). Dogs were sedated intravenously with butorphanol tartrate and midazolam HCl, and their IOPs were measured with the Icare® Tonovet rebound tonometer. The Reichert Model 30™ Pneumotonometer was used to measure OPA. Central corneal thickness (CCT) was measured via Accutome® PachPen, and A-scan biometry was assessed with DGH Technology Scanmate. All outcome measures of left and right eyes were averaged for each dog. Data analysis was conducted with ANOVA, ANCOVA, and regression models.Results:ADAMTS10-OAG-affected dogs displayed a greater IOP of 23.0 ± 7.0 mmHg (mean ± SD) compared to 15.3 ± 3.6 mmHg in normal dogs (p < 0.0001). Mutant dogs had a significantly lower OPA of 4.1 ± 2.0 mmHg compared to 6.5 ± 2.8 mmHg of normal dogs (p < 0.01). There was no significant age effect, but OPA was correlated with IOP in ADAMTS10-mutant dogs.Conclusion: The lower OPA in ADAMTS10-mutant dogs corresponds to the previously documented weaker and biochemically distinct posterior sclera, but a direct relationship remains to be confirmed. The OPA may be a valuable clinical tool to assess ocular stiffness and an individual’s susceptibility to IOP elevation.

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Section: Discussionmentioning

confidence: 99%

Ocular pulse amplitude (OPA) in canine ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

Raphtis,

Sharma,

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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“…Asbjwn M . Tvlnjum study corneal pulsations (Susuki 1960, Bynke & Krakau 1964, Lester 1966). These methods have limitations in determining the exact size of the intraocular pressure variations.…”

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confidence: 99%

“…van Beuningen (1960) described a refined electronic Schistz tonometer and its application to the study of the intraocular pressure variations. Since then a series of modifications in the design of this equipment have been described and their applications reported (Comberg & Pilz 1961, Davanger 1963, Krishna & Botelho 1963, Castrkn & Lavikainen 1964, Rodriguez-Barrios & Solis 1966, McLean & Galin 1966, Galin & Harris 1966, Bron, Knox & Gaasterland 1967, Hsrven 1968. Particular interest has been paid to the study of the changes of the intraocular pressure and the ocular pulsations in stenosis and occlusion of the carotid artery.…”

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confidence: 99%

Studies on the Ocular Pulse Pressure Wave in Human, Dog, and Rabbit Eyes With a Pneumatic Tonometer

Tønjum

1972

Acta Ophthalmologica

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A method of studying the intraocular pressure and the ocular pulse pressure by means of pneumatic tonometry is described. Reproducible recordings have been obtained even in conscious rabbits and dogs. The reliability of the recordings of the ocular pulse pressure, or the ocular pulse wave amplitudes, has been confirmed by comparison with a manometric system in which particular attention was paid in the design to avoid damping of the pulse waves. There was fairly good agreement between the values of the pulse pressures obtained with these two methods. Values of intraocular pressures and ocular pulse pressures recorded with the pneumatic tonometer in normal human, rabbit, and dog eyes are given. The ocular pulse pressure values found were considerably higher than those reported by investigators using other methods and other experimental conditions. Key words: ocular pulse pressure -pneumatic tonometry -conscious animal.Pulsations of the eye have been known f o r more than one h u n d r e d years. Detailed studies of the ocular pulsations were done by Thiel (1928) w h o devised an apparatus t o record the reflection of a light beam from a mirror resting o n the cornea. Since then a variety of methods h a v e been employed to

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Oculosphygmography in Acute and Chronic Carotid Insufficiency

Patterson¹

1970

Archives of Neurology

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Ocular Oscillometry in Cerebrovascular Disease

Cited by 15 publications

References 19 publications

Ocular pulse amplitude (OPA) in canine ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

Ocular pulse amplitude (OPA) in canine ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

Studies on the Ocular Pulse Pressure Wave in Human, Dog, and Rabbit Eyes With a Pneumatic Tonometer

Oculosphygmography in Acute and Chronic Carotid Insufficiency

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