Ocular Neoplastic Disease

Mahajan, Amit; Crum, Alison V.; Johnson, Michele H.; Materin, Miguel A.

doi:10.1053/j.sult.2010.12.001

Cited by 30 publications

(26 citation statements)

References 36 publications

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“…Since the initial descriptions of the MR imaging appearance of various ocular masses, continued technical advances in MR imaging have allowed higher resolution imaging and enhanced characterization of lesions. [1][2][3][4][5] Despite high spatial resolution, MR imaging by using routine sequences is sometimes unable to distinguish different ocular masses and may be limited in its ability to detect ocular masses in the presence of hemorrhagic/exudative retinal detachments, due to suboptimal tissue contrast. Thus, it would be helpful to evaluate additional MR imaging techniques capable of providing different forms of tissue contrast that may aid in the detection and further characterization of ocular masses.…”

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confidence: 99%

Diffusion-Weighted Imaging of Malignant Ocular Masses: Initial Results and Directions for Further Study

Sepahdari¹,

Kapur²,

Aakalu³

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Ocular masses represent a spectrum of malignant tumors and benign lesions that are sometimes difficult to detect and differentiate by conventional imaging techniques. The aim of this study was to characterize a group of malignant ocular masses with DWI, with the goals of establishing reference data and identifying potential clinical applications for improved noninvasive characterization.

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confidence: 99%

Diffusion-Weighted Imaging of Malignant Ocular Masses: Initial Results and Directions for Further Study

Sepahdari¹,

Kapur²,

Aakalu³

et al. 2011

AJNR Am J Neuroradiol

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“…However, in the diagnosis and treatment of patients with uveal melanomas, researchers conclude that many imaging modalities, including MRI, have yet to take on a specific role [3,7]. At this point in time, the literature suggests that the use of MRI in ocular lesions best serves as a compliment to ultrasonography and ophthalmologic examination [27].…”

Section: Discussionmentioning

confidence: 99%

“…MRI findings are beneficial in determining the extent of ocular tumors and involvement of orbital and extra-orbital structures [7,8]. This is specifically valuable when determining the treatment or prognostication of patients with concern for malignancy.…”

Section: Introductionmentioning

confidence: 99%

T2 Fluid-Attenuated Inversion Recovery Imaging of Uveal Melanomas and Other Ocular Pathology

Damento¹,

Koeller²,

Salomão³

et al. 2016

Ocul Oncol Pathol

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Background/Aims: This study describes patterns of intraocular lesions on T2 fluid-attenuated inversion recovery (FLAIR) imaging, exploring a prospective role of FLAIR imaging sequence in diagnosis and treatment. Methods: A retrospective study of orbital magnetic resonance imaging (MRI) studies from the years 2000 to 2015 was performed. MRI sequences included: pre-contrast T1-weighted, T2-weighted, T2 FLAIR, and postcontrast T1 and T2 imaging gadolinium, which were evaluated by a neuroradiologist. Two cases of melanoma were correlated to their pathology. Results: Twenty-four patients with intraocular pathology were evaluated. All lesions, regardless of pigmentation, revealed previously described melanotic patterns on T1- and T2-weighted images; 80% of 10 melanomas localized were hyperintense on T2 FLAIR, which better delineated lesion margins. All of the four inflammatory pathologies on T2 FLAIR were hyperintense, as were 80% of the amelanotic neoplasms. Pathology of two large uveal melanomas paralleled the findings seen on T2 FLAIR. Conclusions: T2 FLAIR appears beneficial in the demarcation of pigmented ocular lesions and may aid in determining protein content or previous treatment. Data also promote previous assertions that blood flow impacts intensity of lesions on T2 FLAIR. Further research is warranted.

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“…Associated retinal detachment is common in both medulloepithelioma and retinoblastoma. Local spread of medulloepithelioma can occur posteriorly along the uveal tract or anteriorly along the posterior aspect of the lens [ 10 ]. Distant metastasis is rare.…”

Section: Imaging Featuresmentioning

confidence: 99%