2021
DOI: 10.1097/aci.0000000000000767
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Ocular mucous membrane pemphigoid: novel treatment strategies

Abstract: Purpose of reviewTo describe current treatments of ocular mucous membrane pemphigoid (OMMP), including conventional systemic immunosuppression (CIST) and novel biologic agents.Recent findingsCIST remains the main stay therapy for the management of OMMP. The choice of agents is tailored to disease severity – mild disease is treated with dapsone, whereas moderately severe cases are often treated with mycophenolate mofetil or sulfa-based drugs and severe cases are treated with cyclophosphamide. In recalcitrant di… Show more

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Cited by 3 publications
(3 citation statements)
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“…Early diagnosis and suitable treatment are essential to prevent the severe and limiting consequences of MMP. There is limited evidence to guide therapy, considering the rapid onset of treatment on moderate to severe disease, using prednisolone, dapsone, sulfapyridine, mycophenolate mofetil, azatioprine, intravenous cyclophosphamide, intravenous immunoglobulin or rituximab as options 6,7 …”
Section: Discussionmentioning
confidence: 99%
“…Early diagnosis and suitable treatment are essential to prevent the severe and limiting consequences of MMP. There is limited evidence to guide therapy, considering the rapid onset of treatment on moderate to severe disease, using prednisolone, dapsone, sulfapyridine, mycophenolate mofetil, azatioprine, intravenous cyclophosphamide, intravenous immunoglobulin or rituximab as options 6,7 …”
Section: Discussionmentioning
confidence: 99%
“…A lokális kezelés a szubjektív tüneteket rövid távon enyhítheti. Ilyen lehet a konzerválószer nélküli műkönny, a szemcseppben és/vagy subconjunctivalis injekcióban adott kortikoszteroid, szemcseppben ciklosporin [14]. A súlyos száraz szem tüneteinek kezelésére szóba jöhet lokális autológ szérumos készítmény alkalmazása.…”
Section: Terápiaunclassified
“…Az immunmodulációs terápia bevezetése nem késlekedhet a súlyos esetekben, az immunszuppresszív kezelés (mikofenolát-mofetil, ciklosporin) hatásos lehet. A biológiai ágensek közül a legjobb eredményt a rituximabtól várhatjuk [14]. A betegség későbbi stádiumában kialakuló elváltozások sebészi kezelést igényelnek.…”
Section: Terápiaunclassified