Ocular Monkeypox — United States, July–September 2022

Cash‐Goldwasser, Shama; Labuda, Sarah M; McCormick, David W.; Rao, Agam K.; McCollum, Andrea M.; Petersen, Brett W.; Chodosh, James; Brown, Catherine; Chan-Colenbrander, Suk Yin; Dugdale, Caitlin M; Fischer, Michael; Forrester, Amy; Griffith, Jayne; Harold, Rachel; Furness, Bruce W.; Huang, Vivian; Kaufman, Aaron R.; Kitchell, Ellen; Lee, Rachel; Lehnertz, Nicholas; Lynfield, Ruth; Marsh, Ketzela J.; Madoff, Lawrence C.; Nicolasora, Nelson; Patel, Dharmendra; Pineda, Roberto; Powrzanas, Trey; Roberts, Afsoon D.; Seville, Maria Teresa; Shah, Ami A.; Wong, Joshua M.; Ritter, Jana M.; Schrodt, Caroline A.; Raizes, Elliot; Morris, Sapna Bamrah; Gold, Jeremy A W; Asif, Amimah; Beeson, Amy; Bhatia, Ramon; Borah, Brian F.; Chatham-Stevens, Kevin; Choudhary, Rewa; Click, Eleanor S.; Filardo, Thomas D.; Galang, Romeo R.; Haston, Julia; Hsu, Sophia; Kaur, Gurpreet; Kimball, Anne; Lee, James T.; Marx, Grace E.; McNicholl, Janet M.; Miller, Maureen J.; Noe, Rebecca S.; O’Connor, Siobhán; O’Laughlin, Kevin; Padgett, Kia; Thompson, Gail L.; Tobolowsky, Farrell; Zulu, Isaac

doi:10.15585/mmwr.mm7142e1

Cited by 62 publications

(51 citation statements)

References 3 publications

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“…As of this report, monkeypox was a cause of death or contributing factor in five of these deaths; six deaths remain under investigation to determine whether monkeypox was a causal or contributing factor; and in one death, monkeypox was not a cause or contributing factor. ** Health care providers and public health professionals should be aware that severe morbidity and mortality associated with monkeypox have been observed during the current outbreak in the United States ( 6 , 7 ), particularly among highly immunocompromised persons. Providers should test all sexually active patients with suspected monkeypox for HIV at the time of monkeypox testing unless a patient is already known to have HIV infection.…”

mentioning

confidence: 99%

Severe Monkeypox in Hospitalized Patients — United States, August 10–October 10, 2022

Miller¹,

Cash‐Goldwasser²,

Marx³

et al. 2022

MMWR Morb. Mortal. Wkly. Rep.

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132

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us-map.html ¶ A list of severe manifestations of monkeypox can be found at https://emergency. cdc.gov/han/2022/han00475.asp. ** During the study period and as of October 21, 2022, CDC was notified by state and local jurisdictions of five decedents whose death certificates included monkeypox as a cause of death or contributing factor, six decedents whose cause of death is still under active investigation, and one decedent in whom the death was not monkeypox-related. Additional monkeypox cases involving severe disease or death might not be included in this report if CDC has not yet been notified about the case or if the case occurred outside of the study period.

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mentioning

confidence: 99%

Severe Monkeypox in Hospitalized Patients — United States, August 10–October 10, 2022

Miller¹,

Cash‐Goldwasser²,

Marx³

et al. 2022

MMWR Morb. Mortal. Wkly. Rep.

Self Cite

132

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“…Ocular and periocular mpox infection has been described in limited case reports and series. 13 These reports include case of conjunctivitis 5,14-17 (with or without follicles), keratitis 5 and periocular skin involvement 5,15,17 . However, most involvement in the reported cases is mild without long-term sequela.…”

Section: Discussionmentioning

confidence: 99%

“…Ocular manifestation typically presents as conjunctivitis but in severe cases may progress to keratitis and corneal ulceration with permanent vision loss. 5 Diagnosis is often suspected on a clinical basis in patients presenting with characteristic lesions but may be con rmed with serologic con rmation of IgM anti-monkeypox antibodies or with PCR ampli cation of viral DNA from lesional swabs. Treatment with the antiviral tecovirimat is available under an Expanded Access Investigational New Drug protocol for patients with severe disease or at risk for severe disease.…”

Section: Introductionmentioning

confidence: 99%

Severe Monkeypox Infection of the Eye and Periocular Region

Bacorn

Majidi

Schultz

et al. 2022

Preprint

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Background: Monkeypox is an emerging zoonotic infection with potentially severe ocular and periocular consequences, particularly in immunocompromised patients. Case Presentation: Two cases of monkeypox presenting in patients with AIDS are described. In the first case confluent lesions resulted in orbital compartment syndrome and total eyelid necrosis. In the second case eyelid involvement was accompanied by corneal melt and perforation. Despite aggressive treatment both patients developed permanent loss of vision and, in one case, death. Conclusions: Many cases of ocular or periocular monkeypox are mild and self-limiting. In immunocompromised patients more severe disease may manifest and requires systemic as well as local ophthalmologic treatment.

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“…Los casos de este brote epidémico 2022 se han presentado con algunos síntomas atípicos y presentaciones no habituales comparado con brotes epidémicos previos de VM. Por ejemplo, ausencia de período prodrómico, escasas lesiones cutáneas o únicas, lesiones ubicadas en regiones no habituales como la ocular y, especialmente las regiones perianal y genital 8 .…”

Section: Características Del Brote Epidémico Actual De La Viruela De ...unclassified

De la erradicación de la Viruela Humana a la emergencia de la Viruela Símica o de los Monos en la década de los virus

Hupat

2022

Andes pediatr

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Ocular Monkeypox — United States, July–September 2022

Cited by 62 publications

References 3 publications

Severe Monkeypox in Hospitalized Patients — United States, August 10–October 10, 2022

Severe Monkeypox in Hospitalized Patients — United States, August 10–October 10, 2022

Severe Monkeypox Infection of the Eye and Periocular Region

De la erradicación de la Viruela Humana a la emergencia de la Viruela Símica o de los Monos en la década de los virus

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